Tuesday, November 5, 2013

Fat Burning Beast = Sugar Burning Gut (Guest Post: Tim/TATER)

Guest Post: Tim/TATERTOT, the revolutionary, rebellious and slightly irreverent on the gut microbiota, fermentable substrates, butyrate colonocyte preference, and risk of colon cancer on a Paleo Diet lacking RESISTANT STARCH.


ROLYPOLY
Hank Williams


"Roly Poly
Eatin' corn and taters
He's hungry every minute of the day
Roly Poly
Gnawin' on a biscuit
As long as he can chew it it's okay

He can eat an apple pie
And never even bat an eye
He likes anything from soup to hay
Roly Poly
Daddy's little fatty
I bet he's gonna be a man someday"



In 1950 fat people didn't get the respect they do today...everybody knew it was simply a matter of eating too much pie. Fat kids were lazy and ate too much candy--a day hoeing the field would put an end that!

Flash forward 50 years, we've come to realize it's not Roly Poly's fault, sugar is the problem. And not just sugar--all carbohydrates make us fat. Every Paleo blogger will challenge you: Do you want to be a sugar-burner or a FAT BURNING BEAST???? The answer is obvious. We don't want to be Roly-Poly, we want to be Grok.

So, we give up sugar and most carbs, cutting out the easy ones first...grain, bread, potatoes, rice, beans, yams, and most sugary fruit. We lose weight, become FAT BURNING BEASTS and live our life swinging through the treetops in top physical form. Or so it would seem.

Sometimes our outward appearance doesn't match what's going on inside. We may lose weight and improve many health markers like blood pressure, cholesterol, and triglycerides, but what is happening in our guts?

More and more attention is being given to the trillions of microbes living in our large intestine. Advanced methods have been devised to identify the different species and families of microbes that make up our gut flora. A healthy gut flora is an amazing thing. The gut flora's main contribution is it's ability to ferment undigested carbohydrates and turn them into short chain fatty acids, such as butyrate, propionate, and acetate, which are used by cells which line the colon (colonocytes), the liver, and muscle tissue. This fermentation of undigested carbohydrates also results in the production of vitamin B and K as well as some important brain chemicals, like serotonin. There is hardly a single facet of our metabolism and biochemistry that isn't effected by our gut microbes.

Reports come out regularly that meat consumption is harmful to the health of humans.

In 2009, it was Meat Intake and Mortality which concluded, ""Red and processed meat intakes were associated with modest increases in total mortality, cancer mortality, and cardiovascular disease mortality."

In 2012, it was Red Meat Consumption and Mortality, which warned us, "we found that greater consumption of unprocessed and processed red meats is associated with higher mortality risk. Compared with red meat, other dietary components, such as fish, poultry, nuts, legumes, low-fat dairy products, and whole grains, were associated with lower risk."

And just recently in 2013, Intestinal Microbiota Metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis, "Our studies reveal a new pathway potentially linking dietary red meat ingestion with atherosclerosis pathogenesis."

So, it would seem settled that red meat is bad for us, leading to heart disease and early death. All of the major media outlets were all over these studies--proof that maybe we should all be vegans! Then these stories hit the paleosphere; every blog and forum joined forces to tear these studies apart...'may cause...' 'potentially leads to...' 'modest increases in...'. Maybe it's not settled. Even our own Dr BG joined forces with the low carb elite, saying in 2009:

"Low carb, high sat fat...Is it really that easy?
--raise HDLs
--lower dense small LDL
--shift to Pattern A from BBBBAD
--feel more energetic, vibrant, younger with maximum vitality"

Meat's not bad...carbs are bad.



But back to those funny critters residing in our guts, the ones that comprise 90% of our total cells. The ones that do so much for us...what do they want to eat? Carbs! And not just any carbs, in fact they don't like sugar and refined grains like white bread, it causes them to grow out-of-control in the most awkward places. No, they like the carbs that nature intended for them to get. Carbs from starchy tubers and fruits, tough plant cell walls, seeds, nuts, and even those found in honey. Non-starch polysaccharides, oligosaccharides, resistant starch, arabinogalactin, or whatever the form--we need it. Human Breast Milk contains over 100 different forms of Human Milk Oligosaccharides (David E Mills 'A Milk-Oriented Microbiota (MOM) in Infants—How Babies Find their MOMs'; photo credit from slide 11).  Babies who get none of these prebiotic substances fail to thrive. All formula for non breastfed babies will contain some form of prebiotic, usually a galacto-oligosachharide.

Lack of a suitable fermentable substrate is bad for babies, but why should an adult care? Especially an adult FAT BURNING BEAST? If you don't eat sugar (or many carbs) why should you care if you have microbes who ferment them?

A recent paper examined this question:
Colorectal Carcinogenesis: A Cellular Response to Sustained Risk Environment

Luckily, the words Red and Meat didn't appear in the title, otherwise it would have already been spread across the airwaves and summarily dismissed by the low carb warriors. This paper looks specifically at what happens at the gut level in people who willfully, or otherwise, disregard the feeding of their gut flora.

Guess what happens? We become SUGAR BURNING BEASTS! You read that right--the cells which line our intestines, the ones that prefer to burn indigestible carbohydrates, must now burn sugar. Roly Poly, daddy's little fatties! Bet they're gonna be a man some day.

Source: Figure 2

"In normal healthy large intestine, butyrate is a preferred energy source. However, in the shortage of butyrate, attributed partly by "Western diet", glucose is substituted as the energy source for survival of these colonocytes. As they evolve to adapt to the new conditions, genetic manipulations are initiated with subsequent loss of function of critical genes and eventual loss of ability to undergo programmed cell death."

"Digestion of the major nutrients in the human small intestine is incomplete, especially that of complex carbohydrates. Humans possess only one intrinsic polysaccharidase, α-amylase, which can hydrolyse only one polysaccharide (starch). Dietary fibre consists principally of NSP which resists small intestinal enzymatic hydrolysis completely such that they pass into the large bowel quantitatively. There is also strong evidence that the ileal digestibility of starch is less than 100% and a fraction, depending on the nature of the food and an individual's characteristics, pass into the large bowel. This fraction is termed RS. The importance of NSP to colonic function is recognised. However, it is becoming apparent that RS may be as (or even more) important."

"Diets that are high in fermentable fibre, in particular RS, and low in fat and protein lead to an environment in the colon which is considered low risk for the development of CRC. Experimental studies in humans and animals have shown that this gives a colonic environment which is relatively high in SCFA and of low pH, leading to a low level of free ammonia and other basic cytotoxins. The mucosa itself is well perfused, giving high oxygenation, while the availability of SCFA spares glucose utilisation. There is strong evidence that O2 supply is critical for hepatic metabolism, especially glucose homoeostasis, and there is evidence also that the entero-pancreatic axis may be involved in CRC risk with high insulin and insulin-like growth factors being implicated. Animal and human studies suggest that fermentable carbohydrates improve blood glucose control so that it is possible that insulin may also be low in this scenario. Populations with a low risk of colonic cancer have been shown to have lower faecal pH than in higher risk groups"

'Hold on!', you say, 'We've been eating fiber for years! My Protein Bar alone has 15 grams of fiber!'

This is where we need to re-think our views on fiber. The term 'dietary fiber' is actually meaningless as far as our gut flora is concerned. What we need to be concerned with is prebiotic fiber. It doesn't take much for a manufacturer of health food to get a 'high in fiber' rating for it's processed crap-in-a-bag.

The following terms describe products that can help increase fiber intake:

  • High fiber: 5 g or more per serving
  • Good source of fiber: 2.5 g to 4.9 g per serving
  • More or added fiber: At least 2.5 g more per serving than the reference food


According to this, 'high fiber' is only 5g in a serving. That's pitiful. A small green banana has 15-30g of resistant starch. A cup of cooked and cooled rice has 10g. It's very important we eat a variety of whole foods, as Dr BG says:

--feed with fiber (resistant starches, heirloom and native tubers, organic whole non-gluten grains, lentils, chana dal, legumes)

I'm glad she's come around, aren't you?

62 comments:

Anonymous said...

Soooo? How much fiber do I need?

Just kidding! Thanks, Grace--looks great!
Tim

marie curieous said...

Great writing Tim! Thanks for showcasing this info Grace. You two are a dynamo combination :)

Dr. B G said...

Thanks Marie. Hee hee, tag. Your next.

marie said...

Ahaha, not likely, I can't write to save my life! But you're kind :)

Anonymous said...

What about people have to use Gap, SCD diet?

Alex said...

From everything I've read, starchy foods, like potatoes, grains, and legumes, are not the only path to good colon health. Other articles mention cabbage, carrots, apples, berries, winter squash, etc. as having beneficial fermentable fiber. With my carb sensitivity, starch is the one thing I need to avoid in order to keep my blood sugar stable, but apples, berries, and carrots are regular dietary staples for me.

Anonymous said...

Anon - Tim's Take:

I think GAPS and SCD are a good way for people to break free of SAD and carb addiction, but not truly a long-term solution for a great gut.

GAPS is said to be useful in Autism, and Autism is linked to gut microflora. However, GAPS never really addresses long-term gut health. It eliminates many of the foods that are needed to feed a flourishing gut microbiome. GAPS might be good to eliminate some of the symptoms of SIBO and leaky gut, but longer term solutions are needed.

DrBG's Weed-Seed-Feed protocol takes GAPS and SCD to the next level. I am a firm believer that people need to know exactly what they are dealing with through testing--not just checking boxes on a list of common symptoms. Once this is known, healing can be more targeted.

Tim

Anonymous said...

Alex - Tim's Take:

I think you are mistaken, but it is a very common belief you have. Gut health relies on eating more than low carb fruit and veggies.

Most recent research in a well-functioning gut focuses on the need for fermentable fiber. There are definitely fermentable fibers in cabbage, carrots, apples, berries, winter squash, etc..., but it's not enough to satisfy the need for lots of butyrate. The main butyrate forming fibers are resistant starch, gum, pectin, and mucins. The other fibers contained in fruits and veggies are known as non-starch polysaccharides (NSP). NSP plays a very minimal role in butyrate production. Starch and starch products play the biggest role in gut health. http://physrev.physiology.org/content/81/3/1031.full

Like I pointed out in the article above, when the gut is deprived of starch and RS, it has to run on something. Just like our bodies can run on glucose or ketones, colon cells run preferentially on starch products, but can also run on glucose supplied via the bloodstream.

When running on glucose, colon cells--and their leaky junctions--become susceptible to genetic mutations and evolve into cells not subject to normal controls. Prolonged starvation of butyrate leads to cell mutation and can progress to leaky gut, bowel diseases, and cancer. Restoring butyrate to the colonic environment causes these cells to self-destruct (apoptosis) and a new ones to take their place.

I think it is imperative that everyone get some quality resistant starch and other butyrate producing fiber in their diet as quickly as possible.

Cooked and cooled rice and potatoes (OK to reheat a 2nd time), green bananas, dried plantains, glucomannan (shiritake noodles), or supplements of larch arabinogalactin, psyllium husk, guar gum, pectin, or plain, raw starches of potato, tapioca, or mung bean.

But still keep eating the foods you are--they are all great, nutritious, and contribute to gut health in other ways.

Dr. B G said...

Anon~

I like GAP and SCD but find them excessivly restrictive and failing to address the root cause of the problem which is microbes/parasites/viruses and parasites/worms in the small intestine. SIBO. SIBO is at the heart of nearly all chronic diseases whether it's mental or musculoskeletal or organ centered (liver, GI, gonad, cancer). Ancient civilizations (and smart animals - elephants, chimps, etc) utilized clay, ash, charcoal to reduce SIBO. Other 'tools' and technology include antimicrobial and antiparasitic herbals.

We have all these at our fingertips now. SIBO can be fast tracked to a cure by employing this all judiciously, instead attempting to 'starve' out the critters for 18-24 months as heartburn Norm or GAPS or SCD advocate. yes these may work but the patient compliance and efficacy I believe are low. Also there is collateral damage for those with dysfunctional adrenal glands. The diets are either too low carb/ketotic or too high in simple sugars (glucose, fructose) to avoid the FODMAPS. Who has adrenal problems? Well. that's everyone. Hardly do I meet anyone these days with adequate and spanking good adrenal function. FYI Doctors are probably the worse as their long hours of training, long-calls, overnight hospital stays, etc put them precisely into adrenal dysregulation. If you don't believe read the latest books on adrenals from smart physicians -- Lena Edwards MD and Sara Gottfried MD.

You can read more about antimicrobials and antiparasitics here:
http://drbganimalpharm.blogspot.com/2013/09/my-n1-pre-and-post-microbiome-digestion.html

Dr. B G said...

Alex~

The funny thing is that for insulin resistance and BG control, RS is the best. This was seen in the Paleo study by Frassetto which employed 250 grams per day of carbs and starches. The ones that contained RS were yams and carrot juice (presuming fiber was retained).

The KEY is that these effective diets are LOW GLYCEMIC INDEX despite being technically 'high carb'. The net carbs was probably 30-50% of the carbs (70-120 grams/day).

Have you read Mendosa? I was really into him 6-7 yrs ago. He wrote a lot about chana dal -- a very high RS, low carb lentil. The RS can reverse insulin resistance.

http://www.mendosa.com/chanadal.html

I love Richard, Marie and Tim. They've done some really neat little trials on themselves that mirror the RS/insulin studies well. These as you aware posted at Free The Animal. RS improves the metabolic picture. When combined with NSP, the results are even more stellar. You add in the right probiotic, BOOM! ~ the gut lining and SIBO can be healed completely.

I concur with everything Tim said above. You should examine the RS and insulin resistance studies. RS may not move the BG (this is why this is a stupid single metric) but RS globally improves
--insulin resistance
--insulin both fasting and post-prandial
--HgbA1c (the 2 month BG average)
--inflammation

Inflammation is lowered because healthier guts and microflora produce volative SCFA and butyrate and tighter junctions.

If you don't see improvements immediately with RS, then youre flora is extinct. try some SBO probiotics. Right now my favorites are

http://www.gomegaspore.com/faqs/

http://www.iherb.com/Advanced-Orthomolecular-Research-AOR-Advanced-Series-Probiotic-3-Natural-Probiotic-Formula-90-Veggie-Caps/43463

http://www.magneticclay.com/store/prescript-assist-probiotic.aspx

Yaelle said...

Hi; Richard Nikoley over at Free The Animal asked me to post here with my weird reaction to RS, that you might have some insight for me.

I've been free from gluten for 3 years and focused mostly on fats and meats from healthy animals, organic or raw dairy, vegetables, a little fruit. But on top of all that good stuff, I've had off and on a deadly addiction to milk chocolate. It's on right now. And I am overweight. I had a baby two years ago and I don't work out much at all.

Once about 4 months ago I decided to try the RS in the form of PS, and started with 1 tbsp twice a day, working up to 2 tbsp twice a day. I didn't have that much additional gas, and no cramping happened, but after a week or two, TMI but I need to say it, I started to get very loose urgent stools (not watery) at the end of the day and early morning. I decided to stop the RS, but the diarrhea continued about 3 weeks more after I stopped. In the end, I concluded that maybe it wasn't the resistant starch causing it.

This week I decided to really try to get off the opium, I mean milk chocolate, and to clean up my diet. Because it helps blood sugar, I decided to try the RS again. Normally, TMI, my stools are frequent and barely formed but formed. Well, after day 2, I saw they were losing form and becoming more urgent. After day 3, when I did have 3 tbsp of RS, they went to urgent loose stools. I said, "I'm out." I don't have time to hang around the toilet all morning. Immediately after stopping the RS, 24 hours later they were normal for me again.

What do you think this is? Not much gas, zero cramping, just diarrhea (not watery). Does this point to something more serious with my gut biome? Or the parasites thing you are talking about?

Thanks for any insights.

Dr. B G said...

Yaelle ~!

Thank you for your comment. Good for you for going gluten-free before your baby. Congratulations on a GF baby!!! I am very envious of the health of your baby ;) Strong work!! Do you notice differences with other babies? Does your meet milestones faster? Better motor control? Excellent muscle tone and strenght??!

Yes you must have an 'off' gut biome. One of the tests for SIBO is to see the reaction to inulin that you can buy over the counter (a fiber -- actually a FODMAP).

You are having the exact postive test for SIBO. GI upset, gas, diarrhea or constipation, etc.

Unless you had your ileo-cecal valve broken or amputated (short gut syndrome), then I suspect that SIBO is in the clinical gut picture. Its very common. Don't despair. All reversible (because a moron like me did it).

Read this:
http://mdheal.org/parasites.htm
http://mdheal.org/leakygut.htm

Even if no parasites are around (like my 2011 functional medicine lab results) then there can be overgrowth of the 'good gut flora' but in the wrong place. Growth of fungi, candida In SIBO, there are creatures in the small intestines which should be the home instead to only a few organisms (like segmented filamentous bacteria and SBO), not a whole metropolis.

Are you having difficulty meeting you health goals? Any sleep, mood or hormonal issues? Inability to gain muscle? Any autoimmunity? Any strong family history of autoimmune diseases that you'd like to avoid? Any history of cancer, heart disease, or inflammatory condition for you?

If yes to any of the above, consider the value of a few gut targeted interventions. Below are the things that helped me and cured SIBO.
--walking or mild-mod exercise daily for one hour (10,000 steps)
--yoga
--two rounds of anti-parasitic regimens with two weeks in between
--during the two weeks take Edible Clay or something similar or charcoal
--with all the above, introduce good flora -- kraut, kvass, SBO probiotics (see above) everyday with PS (consider try again low dose, but consider stop if issues again)



The anti-parasite regimens also have the added merit of being antimicrobial and antifungal. The below is from an excellent Paleo supplement company that I love.

http://www.rockwellnutrition.com/GI-Microb-X-Caps-by-Designs-For-Health-DFH_p_1392.html


I list the ones I've used and give to clients here:
http://drbganimalpharm.blogspot.com/2013/09/my-n1-pre-and-post-microbiome-digestion.html

Hope to hear about your progress and improvements in the near future. Please don't hesitate to ask more questions!
grace

The Natural said...

Hello Dr. Grace, I am directed to your blog by Tatertot and Richard from FreeTheAnimal. I was chatting with them about getting my gut profile mapped out and he suggested that I post in your comments section and that you might be able to put me on the right track regarding the GI Effects test from metametrix .com

I basically want to know your opinion on whether this is the right test if I want to find out more about my gut microbiome. And whether this test will tell me enough to fix any imbalances in my gut microbe if any.

Thank you and look forward to your reply.

The Natural said...

Hi Dr. Grace, Your mention of Channa Dal made me curious and read up the Mendosa article you posted above. Man, did I learn something new. I have always believed that channa dal = garbanzo beans but it was revelation to me that channa dal is actually "desi" channa. I would have never guessed that brown (desi) garbanzo are so much superior to the white ones...and to think that I have been eating channa dal in one form or the other my whole life as I am from India.

Dr. B G said...

Not all dal are created equal ;)

Dr. B G said...

Hi The Natural,

I find the testing helpful to know the beast you're fighting. Sometimes it changes the treatment because some pathogens and parasites and helminths require more potent therapeutics to eradicate.

Each test has pros and cons so I like doing two different tests at one single time. The ONE provides the organic acids that the pathogenic overgrowths are puttin out. It's helpful to see the extent. The ONE also gives a battery of other important info like mineral, vitamin deficiencies as well as two advanced cancer markers to track called lipid pedicures and 8OHdG.

The GI fx stool profile will provide the species of the pathogens. It is accurate and reliable because it uses DNA amplification technology which is a millennia ahead of culturing. 80-90% of the life in our gut cannot be grown on petri dishes or cultures at the time. We don't have the capabilities yet. Many are symbionts which would simply die without their friends and unique communities.

Give me a ring/email if interested!

G

Anonymous said...

I'm dumbfounded by this connection between microbiome and immune function. So repopulating your gut flora seems to reverse some hypothyroid symptoms. This seems to revive the bacterial origin of autoimmune diseases:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540616/

Btw, when I try L-Glutamine around 5 grams daily, I experience reduction in autoimmune symptoms as well. L-Glutamine arguably helps rebuild the gut lining of the small intestine, I believe, thus helping fix your leaky gut.

So autoimmune diseases are caused by both leaky gut and gut dysbiosis? Simultaneously? One's the small intestine and the other (at least the kind fixed by resistant starch) is the large inestine, right? Wonder if there is a way to fix both as quickly as possible. Dr. BG, are you aware of any leaky gut fix protocol that's effective? My understanding is that everyone has intestinal permeability to some degree. But it's excessive intestinal permeability that's the problem. How would you even know that you've fixed it?

Dr. B G said...

Anon~

Absolutely. We co-evolved with the biome therefore we rely on them for optimal health and immunoprotection. If we f*ck our biome, they will indeed f*ck us.

OK I just posted a review of my leaky gut protocol. 7 steps.
http://drbganimalpharm.blogspot.com/2013/11/how-to-cure-sibo-small-intestinal-bowel.html

Recently I cured SIBO (again) when I added soil based probiotics after healing most of everything with kraut alone. Most won't get such easy results admittedly. My advantage is that I had all of the mercury and titanium surgically and dentally extracted in the summer 2012. This made the biggest difference for me. Mercury is a problem because now everyone has it. See the Toxome post.
http://drbganimalpharm.blogspot.com/2013/04/babies-and-mapping-pollution-in-people.html


Every baby now born in the USA (estimated from one study) probably has measurable and significant levels of mercury which breaks our gut and causes SIBO (as well as adrenal dysregulation).

What I love about the soil based organisms is that they healed my gut so fast, that my adrenals normalized almost completely. The gut is so ginormous so as you said, even if it is a little impaired, it causes great distress for the entire whole body. Previously I had take salt and supplements daily to maintain functioning adrenals ~~ now, I only occasionally if stress is low and negligible and regular yoga.

This is all before potato starch (prebiotic, food to feed the SBO). PS is the bionic fiber which feeds SBO and strains which have the power and capacity to TIGHTEN UP WEAK AND LOOSE JUNCTIONS.

If you heal the adrenals, then your hypothyroid symptoms will disappear faster because these glands work in tandem, in parallel (like electricity circuits).

Good luck. Hope to hear about your progress and challenges later.

g

The Natural said...

Hi DR. BG , thanks for your reply. Yes, I am interested in doing the GI Fx and ONE although I may have to wait until after Thanksgiving.

How do I get in touch with you- I didn't see your number or email on the blog.

This whole gut microbiota stuff gets more and more fascinating with each study or article I read.

Dr. B G said...

Natural,

Left column ~ look forward to hearing from you!
http://www.blogger.com/profile/15451872961651116061

grace

Anonymous said...

Would inulin powder have the same effect? Much easier to get hold of in Australian than potato starch, etc.

Thanks,
Jill

Dr. B G said...

Jill, In Shanghai I get Australian Simplot potato starch and it works. You may also access iherb.com for Bobs red mill unmodified potato starch. Good luck and please let us know how it works. Unfortunately inulin isn't resistant starch.

The beauty and grace of the indigestible fiber known as resistant starch is that the amylose and amylopectin arrange themselves into tight 'carb' crystalline structures for the very special strains of super microbes to feast on. The structures are double helical shapes very similar to our DNA. Isn't that absolutely BRILLIANT?

Are you taking any soil based organisms for probiotics or homemade organic fermented veggies? These will augment your optimal health responses.

I hope Tim jumps in soon too!

G

Tim said...

But Grace, you are doing such a fine job here!

Inulin is a great prebiotic, but it is not entirely fermented into butyrate like RS. All of the FODMAPs are fermentable fibers, and they too are not entirely fermented into butyrate like RS.

As a complement to a diet high in RS, inulin, psyllium husk, glucomannan, larch aribinogalactin, and other common prebiotics are fine. I think about 5-10g per day of 'other fermentables' is about all you want. With RS, it's best to completely flood the system with it--this pushes the fermentation site or the RS and other prebiotics further and further down the gastrointestinal tract and makes for super-healthy colon--all the way to the end. Most diets, with just a small bit of fermentables, allow for butyrate production in only the first segment of the large intestine. This is the primary reason that colon problems are more pronounced distally and lessen as you reach the proximal colon. We want our entire colon to be a butyrate factory.

Anonymous said...

Jill, Potato Starch is pretty easy to find in Australia (unless you are somewhere far from a city or major town). Just go to any health food shop or the gluten-free aisle of a big supermarket. It's typically there, often multiple sorts, labeled as potato starch. A 500g bag will cost you roughly $12, depending (this is a Queensland price :) Good luck. Lauren

Anonymous said...

Thanks so much for you advice, Dr. BG. I'm just wondering, is SIBO equivalent to leaky gut in the sense that if you fix SIBO, you can fix leaky gut? What if you have an actual autimmune disease? By fixing leaky gut, you'll be fixing food allergies like egg whites, dairy, legume sensitivity?

I'm wondering, if you have an autoimmune disease like RA, you have to fix both SIBO and dysbiosis, right? Since both seem to be implicated in autoimmune diseases.

So do both RS supplementation and your SIBO protocol? Just wanted to clarify. Thanks again and congrats on your informative site, which will be attracting some eyeballs from now on. This will become my stomping ground.

Namby

Dr. B G said...

Jill

Thanks for your comment~!


TIM

'We want our entire colon to be a butyrate factory.'

I LUV THAT~!!!!

g

Dr. B G said...

Namby,

Good questions~!! UR SO SMART.

YES YES YES YES YES and YES. ;)

I used to have Hashimoto's. So did Tim. RA is not much different. When my parents when to med school they learned that autoimmune diseases were 'collagen diseases.' Basically any body tissue can be attacked and start falling apart by the action of our own immune system.

SIBO is leakiness. I'm glad to see that Pubmed is adopting the term gut leakiness more and more. The layer of cells lining the small intestines is only one-cell thick, thus very vulnerable to assault, hijacking and breakdown in structural integrity.
http://www.ncbi.nlm.nih.gov/gquery/?term=gut+leakiness


The microbes that normally live there like SFB (segmented filamentous bacteria) and SBO strains (soil based) are shown in the new T1DM models to play vital roles in maintaining the tight junctions. Truly I believe the biota IS OUR IMMUNE SYSTEM. They regulate so much including the T helper cells and Treg cells and training them to be tolerant and effective against invaders.

Have you heard of molecular mimicry?
http://uws.edu/Academic_Programs/MS_Nutrition_and_Functional_Medicine/WeblikeConnections.pdf

In autoimmunity, something has breached the intestines (small or large or both areas) and made it into circulation of the blood and/or lymph. The immune system will naturally attack it, perceiving that it is foreign. Let's it is a commensal like Prevotella copri. And it happens to look like the tissues lining all the joints? Or it is Candida albicans... which happens to look like thyroid tissue? Or brain tissue? Gluten -- the greatest mimicker looks like them all.... Later, subsequently, you clinically have RA or Hashimoto's or Austism/ADHD spectrum, respectively.

For autoimmunity (or anythign)
HEAL
SEAL
DEAL

(1) Heal the gut and immunity/microbiota (invest in kraut or other fermented foods, SBO probiotics, RS bionic fiber). Stop allergenic foods -- gluten, dairy, soy, nuts, egg whites, corn, whatever top 5 to 10 foods currently eating.

(2) Seal the gut and prevent breach of commensals or pathogenic overgrowths

(3) Deal with hyperactivity of the immune system and auto-antibodies that resemble damaged organs. These immune complexes (target + auto-antibody) are damaging (not the actually microbe). Taking high ORAC plant antioxidants, reducing stress and cortisol/adrenals, exercise, yoga, proper diet, rejuvenating sleep, laughing, etc all help to calm, reset, and normalize the immune system. See #1 and 2.

Hope that helps Namby!

Anonymous said...

Hi Dr. BG

Just a few more questions since I'm trying to meticulously implement what you're saying!

When you say SBO probiotics, you mean soil-based organisms. Any particular brand: Chris Kresser seems to be recommending Prescript-Assist.
If not brand, which particular bacterial strain should it contain: I'm sure you're referring to the 3 strains that promote homeostasis in that T1 diabetes & microbiota article (Sorini & Falcone, Shaping the (auto)immune response in the gut: the role of intestinal immune regulation in the prevention of type 1 diabetes, AJCEP)
(1) Clostridium; (2) B. fragilis; (3) Lactobacillus casei

But avoid inflammatory strains like: (1) SFB; (2) Lactobacillus bifidus?

When you say RS bionic fiber, you mean fiber to take RS with, right? I've googled bionic fiber and found nothing. You mean like psyllium husks, which could move the RS down near the colon?

By ORAC plant antioxidants, you mean like Orac Green Superfood?

Thanks, Dr. BG

Namby

Tim said...

Interesting discussion! I was going to try to talk Grace into letting me do a guest blog some day on leaky gut--here's a preview:

I could never really wrap my mind around leaky gut--I knew it had to do with permeability and junctions. Grace set me straight on these terms and showed my how to refine my searches.

It turns out, leaky gut is real--despite what your doctor may tell you. They all know it, they just don't know how to apply it.

It isn't as simple as it sounds--it's not junctions that are leaking--it's Tight Junctions. There is no such thing as a leaky junction, but there are malfunctioning Tight Junctions--huge difference!

'Tight Junctions' are a part of the GI Tract just like colonocytes, mucus, and the lumen. Tight Junctions are a component of the the junctional complex, which consist of the TJ, gap junctions, adherens junctions, and desmosomes. 'Leakiness' is a real thing in this system.

Intestinal epithelial cells are where nutrients are absorbed. These are known as enterocytes, but also include enteroendocrine, goblet, and Paneth cells. These epithelial cells are tightly bound together by the junctional complexes and are crucial for the integrity of the epithelial barrier.

When these junctional complexes, and Tight Junctions cease to be a barrier, we see chronic inflammatory diseases of the intestine, such as inflammatory bowel disease and celiac disease, type I diabetes, and autoimmune disease. A malfunctioning intestinal barrier is also implicated in immune reactions that target organs outside the digestive tract, leading to diseases such as fatty liver disease and multiple sclerosis in the brain. Furthermore, entry of unwanted antigens can lead to systemic inflammatory response syndrome, characterized by a whole body inflammatory state, and multiple organ failure. You can't make this stuff up!


So, what effects the 'tightness' of tight junctions? Gut microbes and food.

Commensal bacteria and probiotics have been shown to promote intestinal barrier integrity. Probiotic treatment also reduces epithelial barrier dysfunction following psychological stress. L. plantarum was shown to regulate human epithelial TJ proteins in vivo and to confer protective effects against chemically induced disruption of the epithelial barrier. Some probiotics and commensals have also been shown to prevent, and even reverse, the adverse effects of pathogens on intestinal barrier function. Live probiotic bacteria and their dead probiotics differ in their ability to protect against pathogen-induced changes to barrier function. This may be attributed to the fact that live probiotic bacteria are able to compete with pathogens for nutrients for growth and adhesion, whereas dead probiotic bacteria may strengthen intestinal TJ via a cell signaling pathway.

So what about food? Without boring you to death, the worst offenders to Tight Junction functionality are wheat, unsaturated fats (vegetable oil), and chemical food additives--especially surfactants which are used widely in food processing! What foods help to maintain Tight Junctions? Resistant starches, cellulose, pectins, and some oligosaccharides. Have you heard that somewhere before?

There. Now you are all smarter than your doctor. How to seal a gut: Plenty of probiotics and good food! Heard that before?

Here's a link to click if you want to see where this was all plagiarized from: http://jn.nutrition.org/content/141/5/769.full Just in case you think I made it all up--lol

Tim said...

Namby - We are calling Potato Starch BIONIC RS...just an inside joke. Now you are one of us!

Here are a couple of Grace's favorite supplements:

http://www.iherb.com/product-reviews/Garden-of-Life-Primal-Defense-Powder-HSO-Probiotic-Formula-2-86-81-g/3159/?p=1

http://www.iherb.com/Advanced-Orthomolecular-Research-AOR-Advanced-Series-Probiotic-3-Natural-Probiotic-Formula-90-Veggie-Caps/43463

http://www.iherb.com/Paradise-Herbs-ORAC-Energy-Greens-12-8-oz-364-g/10731

Not sure about the last one, there are lots like it--different flavors.

Alexander Hardy said...

Hey Grace or Tim,

I'm a little confused on something- I thought that the presence of any bacteria in the small intestine, either good or bad, would lead to damage of the small intestine and leaky gut would soon follow. So wouldn't probiotics lead to an aggravation of symptoms in those with SIBO? Also, it seems like my girlfriend and I are getting massive heartburn from drinking potato starch dissolved in water. Is this normal? Will it go away eventually? FYI I've never had heartburn before having potato starch.
Thank you so much for your responses!

Alex

Alexander Hardy said...

Also, I'm trying to find a study demonstrating RS's ability to move bacteria from the small intestine back to the large intestine. Can you help me out and post the study you read? Thanks again!

Alexander Hardy said...

Actually, I was able to find this:
http://aem.asm.org/content/67/8/3469.short
So perhaps at the very least RS will be able to attenuate any spillage of bifido from the large intestine to the small intestine? Idk if PS comes in the form of starch granules though, since I don't really know what a granule is.

Tim Steele said...

Alexander - Sorry I missed this, I thought I was subscribed!

http://aem.asm.org/content/66/10/4212.full Look at fig 3&4 for a picture of it happening in real-time!

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183348/

Here the tested the adhesion on cholera, e. coli, and a bunch of other pathogens and it worked pretty good on most.

Yes--PS is in granules! I know what a granule is and if you look at Fig 3 in above study, you will, too!

If you have any more questions please ask!
Tim

Tim Steele said...

Alex - just saw your other comment, too, about heartburn.

I have never heard this complaint before, but since you and your girlfriend are seeing it, we need to deal with it.

The small intestine is actually home to quite a few bacteria normally. There is a thick mucous layer that they live in--this is what is supposed to protect against SIBO, but sometimes the mucous layer is compromised and pathogens get in or even beneficial microbes can overgrow and cause problems. The Small Intestine is not sterile, just not home to as many bacteria as large intestine.

Regarding the heartburn, try just 1/2 or 1TBS for a few weeks if you can, then move up. Try mixing it with yogurt if you can do yogurt. How is your diet otherwise? Hopefully since you are here at AnimalPharm, you have eliminated vegetable oils, wheat, and lots of sugar. Alcohol is a big trigger for SIBO problems, too.

Let us know how it goes, I'm subscribed to this thread now!

Alexander Hardy said...

Fortunately enough, the heart burn completely subsided in both of us the day after I posted that. I'm starting to think that it was something else entirely that caused it, since I can't think of any reason that anyone would get reflux from the PS anyway.
It was probably just some inconsequential blip. False alarm!

Those articles you posted are awesome! I'm surprised they got actual pictures of the bacteria attached to the starch. Not much room left for doubt after that. I saw that you also mentioned that the starch will relocate the beneficial bacteria back to the large intestine as well. Would you be able to link any studies on that besides the one I posted?

Also, I noticed that the health benefits of butyrate production are always talked about in terms of the health of the large intestine and colon and the integrity of the tight junctions there, but is it also helpful for the tight junctions of the small intestine? Sorry for all the questions but I'm so excited about all this RS stuff that I want to make sure that I can back up what I say when I argue with all my VLC paleo friends haha.

I really wanted to thank you for all the work you've done on learning about resistant starch and spreading the word. I've been on a VLC diet for some time now in an attempt to get rid of my SIBO and it was kind of killing me. After taking potato starch I've been able to handle more carbs and my health is improving daily!

Alexander Hardy said...

Oh and one last question! So when you get damaged small intestines and compromised peristalsis, is that just because the mucous layer is gone and the bacteria then grow directly on the wall of the intestine and damage it? And is that why you guys recommend psyllium husk in the bionic RS (lol catchy name)- because it restores the mucous layer in the small intestine as well, thus allowing it to repair itself? I guess that was more like two questions. Thanks again!

Tim Steele said...

Alexander Hardy - Glad to hear heartburn was not related...it was a first for me to hear!

Glad you like to read...read through this: http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN84_05%2FS0007114500002038a.pdf&code=146bd4f5865f95385eecd461067b11c3

In the abstract, it sets up the theory that raw potato starch places more butyrate into the portal vein than corn starch RS, and explores that thought throughout.

This shows me why potato starch fermented in the large intestine is healing to the small intestine.

Also, in the GI Tract, everything is connected--it's impossible to fix the small intestine by 'crapping on' the large intestine, as so many (all) of the other SIBO plans do. SIBO is a systemic problem more than a small intestine problem--that is not just my pet theory, that is the truth.

I hope Grace sees the second question you asked about loss of mucous layer and SIBO--thyat is more her specialty, not mine, but your synthesis of the problem sounds right...

As to the psyllium, in the most recent blog (SIBO part 4) there is a study linked that shows when Psyllium and RS are taken together, they make more butyrate and further down the colon than an equal amount of either substance by itself. Has to do with the speed of fermentation, fermentation preference, and water holding capacity of the psyllium...if you can't find it, let me know and I will link it--the study is on my other computer.

On the issue of RS relocating pathogens...this is the full text of the abstract you posted earlier. Not sure if you saw the whole study, but just jump to the very last paragraph for a quick explanation of how it flushes attached pathogens.

http://aem.asm.org/content/71/8/4850.full.pdf

One thing funny about this study--they did not use raw potato starch to test the adhesion, but they used pre-cooked potato starch to prove it would not work when the starch was digested in the small intestine.

This is a favorite trick of the Hi-Maize company when they don't want their beloved corn product out-shone. In almost every instance where potato starch is compared to Hi-Maize, potato starch out-performs.

For more info on the adherance properties--do a google search for 'resistant starch adhesion probiotic' or something like that. Lots of money is being spent on ways to encapsulate probiotics inside an RS shell because otherwise probiotics die in the stomach. You'll find studies like this:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC93045/

Good luck to you! Keep us posted!

Keep reading here--next week I should get my American Gut results posted in a blog.

Alexander Hardy said...

I'll definitely be on the lookout for your next post! Can't wait to read it. I checked out your first article and it definitely seems like PS has some awesome butyrate and SCFA producing capabilites.. speaking of SCFA production, I also just ran into this study that shows that while SCFA's reduce amplitude of peristaltic contractions in the ileum, it does increase the frequency of the contractions. This means that while the PS may be causing a sizeable increase of beneficial bacteria in the large intestine, there may not be a risk of bifido or other large intestinal bacteria spilling into the small intestine thanks to the increase in contractions of the ileum. So you possibly get a double-whammy from PS: a robust, yet properly-contained gut flora in the large intestine, where they can do their thing and help the small intestine heal.

http://www.ncbi.nlm.nih.gov/pubmed/17187590

I also googled what you suggested and was thoroughly satisfied with the amount of info out there on adhesion of beneficial bacteria to RS.

Again I can't thank you enough for your responses- they have honestly been invaluable to me so far and for once I have reason to feel like I can have confidence in my dietary plan. It's just too bad no one else around me is as enthusiastic about RS as I am haha.

Dr. B G said...

Namby,

Did all your questions get answered? Wow Tim!! That was stupendous. Love how you broke down TJ's and we are not talking about my favorite Trader Joes.

I loved the Sorini et al article that was part of the subject of several posts here. Just FYI the SFB and L bifidus aren't inflammatory the vast majority of cases. I tried to find what you were referring to in the article but didn't find anything. Let me know if it's unclear. Both are commensal strains meaning normal strains in healthy guts.

Lol aha I ended calling RS + NSP bionic fiber because that is truly what it is. It's like super fertilizer for the lawn and ecosystem of a healthy gut. When our gut us happily fed, nurtured, loved and maintained, it does marvelous and wonderful work for us
-- regulate a healthy and balanced immune system
-- longevity
-- bountiful sex hormones
-- happy moods and sleep
-- productive (society, labor, charity, culture)

Here is a specific list of benefits from RS that i posted earlier on the GUT IQ post in October. Thank you for all of your detailed questions. U ROCK. Love the questions.

http://2.bp.blogspot.com/-nrwftWdm2oc/UlAcLZOrl6I/AAAAAAAABgQ/MlBCO7sRcBs/s1600/RS+effects+chart+list.png

G

Anonymous said...

Dr. BG, thanks so much for your reply. Yes, I got a hold of both Probiotic-3 and Primal Defense. Do you think I should take that together? Normally I'd like to isolate the effect by testing one after another. Plus adding psyllium husk and ORAC green powder to my RS. Yes, so, looks like leaky gut and gut dysbiosis are almost synonymous and may have same pathogeneses. Interesting, since antibacterial therapy like Minocin works for RA and some autoimmune diseases. Paul Jaminet basically believes in the infection model of autoimmunity a la lyme disease.

Can't wait to try these and report back. Thanks so much Tim and Dr. BG. Keep up the great work.

Namby

Beta Hydroxybutyrate said...

Great post! You will pry my raw potato out of my cold, dead hands. :)

I have a question though. Do you think if one is on a ketogenic diet that the colonocytes would opt to take up ketones instead of glucose and regain the ability to commit apoptosis?

Tim Steele said...

Beta Hydro - That's quite a stretch. I don't think that colonocytes would run on ketones. But if one is in ketosis, the liver still makes glycogen and BG remains stable--that's what colonocytes would run on.

LZ said...

What a fascinating discussion!

Here are a few relevant links I found while perusing the net in between reading all your comments on this thread:

Potato and high-amylose maize starches are not equivalent producers of butyrate for the colonic mucosa.
http://www.ncbi.nlm.nih.gov/pubmed/11177182

Butyric Acid: an Ancient Controller of Metabolism, Inflammation and Stress Resistance?
http://wholehealthsource.blogspot.ca/2009/12/butyric-acid-ancient-controller-of.html

Fantastic Health Benefits of Butyrate:
http://www.rawpaleodietforum.com/general-discussion/fantastic-health-benefits-of-butyrate-6649/

I'm wondering if pectin would be another good adjunct to the PS/psyllium Bionic RS protocol? How about modified citrus pectin (MCP)?
http://www.dreliaz.org/recommended-product/natural-cancer-support/

What are your thoughts on the possibility that MCP would help to enhance the beneficial effects of the Bionic RS?

Thanks so much to DrBG, Tim and others for sharing all this fantastic information here!

Tim Steele said...

LZ - I think that a pectin supplement wold be a great complement to the BIONIC RS.

I have not bought or tried pectin supplements, but I do know that pectin is an important prebiotic. I wouldn't go too crazy on it, though. Maybe like 5g/day or so. It's one of those things not found in huge quantities in nature.

I found this patent on line some time back and thought it seemed a lot like a crazy frankenfood, but this company has devised a way to 'cross-link' pectin and regular starch to make a supposedly better prebiotic RS: http://www.faqs.org/patents/app/20090118231

If you look at Table 2 in this study, http://onlinelibrary.wiley.com/doi/10.1002/star.201000099/full

You will see that pectin is fermented almost completely into acetate, where RS is fermented into equal parts acetate, propionate, and butyrate. This is clearly where RS beats Pectin, but a small pectin supplement will definitely add width and breadth to a supplement program.

Good call!

Anonymous said...

I need some help. I have a rather complex issue, but was hoping I might be able to get some help here as I have tried everything.

I was overdosed on Testosterone over three years ago. It really messed up my adrenals and my endocrine system bad. I was doing great and then I couldn't get off the couch I was so weak. I would get up for short bursts and then any amount of stress would just put me down. A couple of months a got I got what appears to be some stomach virus and have been pretty much housebound again. I am having severe pressure and bloating in my upper G.I. that goes away (although not completely), then comes back when I try to eat too much....or even when I don't eat. I was having diarrhea, and now I am bordering on constipation. My stomach was fine until this started. A friend told me about this site and I have added some of the suggestions.....a little psyllium and have order the potato starch. I'm drinking a lot of ginger/clove tea and she recommend the SBOS. Can anyone help me? I'm really exhausted and live alone so I don't have much help.
Thank you Merry

Dr. B G said...

Namby,

I didn't finish, sorry. You said 'Yes, so, looks like leaky gut and gut dysbiosis are almost synonymous and may have same pathogeneses. Interesting, since antibacterial therapy like Minocin works for RA and some autoimmune diseases. Paul Jaminet basically believes in the infection model of autoimmunity a la lyme disease.'

So many gut flora are implicated in RA -- Kleb, Prevo, etc. In Hashimoto's and Graves, Yersinia and other species are implicated. For an autoimmune disease to occur our genetic immune markers on cells interact with undigested food (gluten/casein) and the flora that breach the gut via loose junctions and permeability. This is called molecular mimicry and cross-reactivity -- our immune systems are the most elite of all animals on earth yet this is our Achilles heel, our greatest weakness and vulnerability because it relies on our carnivorous SMALL INTESTINES, the largest interface with the world (surface area as enormous as a tennis court). To be fed and for streaming of electrolytes, we need leakiness, right? That is the greatest evolutionary step that took us from the primates, which have different Zonulins. But the control of the leakiness runs humans into problems, esp when we live apart and disconnected from fertile, healthy soil ecosystems.

For Type 1 Diabetes you need
--leaky gut
--missing SFB, SBO and other commensals (newest lit)
--pathogenic enterotype and overgrowths
--gluten

For AS (alklosing spondylitis) you need, generally:
--leaky gut
--HLA B27, HLA DR1/DR4
--Proteus, Klebsiella
--gluten

For celiac disease, you need
--leaky gut
--HLA DQ2.5 or HLA DQ2/8
--gluten

For autism/ADHD/spectrum, you need
--leaky gut
--?HLA something or genotype (DR4?)
--yeast, candida, pathogenic enterotypes
--gluten, casein

For RA (rheumatoid), you need
--leaky gut
--HLA-DR4, or other HLA/genotype
--Prevotella copri, Proteus, or Klebsiella overgrowth; even Bifido is implicated
--gluten, casein

http://www.ncbi.nlm.nih.gov/pubmed/2040685
http://www.ncbi.nlm.nih.gov/pubmed/8835505
http://www.ncbi.nlm.nih.gov/pubmed/21114016
http://www.greatplainslaboratory.com/book/bk7sect1.html
http://www.ncbi.nlm.nih.gov/pubmed/1723358
http://www.jci.org/articles/view/115214/pdf/render

See figure 1
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290812/pdf/AD2012-539282.pdf


WHAT ELSE MISSING? Actually in all these cases it is likely that the beneficial, symbiotic commensals are missing -- SFB, soil based organismis and healthy fungi and bacterial citizens of the sprawling gut ecosystem! Also RS, we are missing the greatest source of balance in the gut ecosystem. RS has multiple roles -- it binds microbes to transport to the large intestine. The soil organisms and pathogens both are evolved to desire to attach and bind to granules of RS. They WANT to go to the large intestine ultimately and then be deposited in the soil to recreate and propogate their species, no? We are all designed on earth this way from bacteriophages to whales... (cont)

Dr. B G said...

One more thing. I love Paul. He is partially correct, partially incomplete I believe. Lyme is everywhere. Prevotella and Klebsiella are everywhere. Candida is indeed equally prevalent. The key is what holds them in check. We will NEVER GET RID OF THEM completely. Modern science loves to eradicate (and so do I LOL). But imho this is futile and hopeless.

SBO + RS = balance to the pathobionts

Did you see this diagram from the Step#5 exercise post from Environmental Health Perspectives journal? I love this. They fully appreciate how the gut ecosystem is synonymous with the earth's ecosystem. We cannot have harmony in our guts unless we understand what havoc and destruction humans wreak on the environment...
http://ehp.niehs.nih.gov/wp-content/uploads/121/9/ehp.121-a276.pdf

They say 'A known pathobiont, Clostridium difficile (pictured above) normally lives dormant in the gut with no ill effects.
Antibiotics can kill off other bacteria that usually control C. difficile. The resulting overgrowth of the pathobiont
may cause inflammation and bleeding of the lining of the colon.33

The Gut in Balance:
The gut microbial community has been called “a forgotten organ” because of its role in facilitating human health—a role that is still being elucidated but that nevertheless is emerging as important.34 Colonization of the gut begins at birth, and the microbial community that develops over time is shaped by many influences, including the individual’s genetic makeup, age, foods and pharmaceuticals consumed, lifestyle, and more. A healthy gut contains a balanced mixture of many commensal (beneficial) species. Under certain circumstances an unnatural shift in this balance can cause microbes that are normally benign or beneficial to induce inflammation. These situationally pathogenic microbes are termed “pathobionts.”5

So Paul is right -- infectious agents are implicated. But Paul is wrong -- it's not necessarily Lyme, it could be simply whatever is living in the gut of fungi, parasitic, pathogenic, protozoa, spirochete, viral, bacterial, or.... undigested peptide origins. The key is SIBO/SIFO and the small intestines.

You're absolutely correct Namby -- antibiotics have been shown to help. They've even been shown to improve gut motility in SIBO cases because motility is an inherent problem. But Rx antibiotics also hinder the rebuilding of the architecture of the gut. They are too strong, potent, manmade, synthetic, and without selectivity for shielding the tender, non-virulent and more vulnerable commensals.

Dr. B G said...

Merry~!

Hang in there. I hear you and I've been precisely where you are. After almost three years of the mirena IUD (levonorgestrel) I later lost two years of my life from the endocrine/adrenal/gut disruption caused by the potent birth control. I think you are having similiar EDC (endocrine disruption).

Read how bad misoprostol -- fake prostaglandin/hormone analog is. The consequences are similar with steroidal chemicals actually. Birth control is know to cause vitamin B12 deficiencies due to gut disruption.

BMJ Case Rep. 2012 Oct 9;2012. pii: bcr2012007005. doi: 10.1136/bcr-2012-007005.

...Literature review revealed that misoprostal can cause overgrowth of clostridial organisms by decreasing the macrophage function and thus can lead to developmental gangrene of reproductive tract and gastrointestinal tract.

PMID 23047999


Have you read the 7 steps?
Did you read my story here?
http://drbganimalpharm.blogspot.com/2013/09/my-n1-pre-and-post-microbiome-digestion.html

For me, these are the things that I did, after gradually the chemical eventually had a biological half-life out of the body (after two years of fatigue, mood, edema). Please read how to remove fat soluble chemicals and toxins safely and effectively out of our body. Everyone should do this. These below are from the experts in the field. These will change your life -- I wish I had them 5 yrs ago! But when youre tired and depressed, too hard.

Marchese '8wks to women's wellness' (her supplements are excellent and a good deal fyi imho)
Crinnion 'Clean Green LEAN'

http://www.drmarchese.com/home/book.html
http://drcrinnion.com/

Please don't hesitate to contact me offline sweetie. Email on the left. http://www.blogger.com/profile/15451872961651116061

g

Dr. B G said...

LZ

Thank you so much for your comments. I love pectin. I think all naturally occuring fiber/RS is good for us. Potato starch or psyllium aren't forever. Neither is SBO probiotics. If we can shift eventually to natural whole foods from the fertile, abundant earth, I think that is best. Currently however I live in a big city and I've co-oped with the best farms here that I can find, but I know it is impossible to eat the optimal diet that I'd like for my family and I. We just do our best ;)

Tim has great knowledge about our little gut critters! Thanks Tim~!! The ecosystem is complex but I think when the key members and the key substrates are present, then it all flows and rolls precisely as all should.

My parents have insanely good health and eat generally without impugnity. There parents had good diets and my parents grew up eating a lot of sweet potatoes and guava. Guava has a low level of pectin and all kinds of low glycemic index fiber.

Pectin is used in jam/jelly making and it's a fiber that gels up or coagulates into that jelly texture with processing.

It's in higher quantities in the more sour fruits (high vitamin C) which are higher in ORAC and antioxidant capacities. Can't be bad, no? And feeds the gut flora well.

http://www.wikihow.com/Test-the-Pectin-Content-of-Fruit

g

Dr. B G said...

Alexander Hardy,

Thanks for your patience! Good questions!! I think you and Tim~ are on a fantastic roll of exploration and discoveries.

Here is a (short) list of some the benefits of RS from my October Gut IQ post. I could go and on and but Tim does it so much better ;)

http://drbganimalpharm.blogspot.jp/2013_10_01_archive.html


Heartburn is either lack of gastric acid or gluten/allergen triggering. Did it ever return with PS? That is weird so glad to hear esp considering that both of you experienced.

It is funny that you discuss mucus because one the switches to make good mucus is gastric acid and those who suffer from sibo/GERD often don't produce adequate acid to trigger protein degrading enzymes or sufficient acidity. Taking Betaine HCL in appropriate doses (too much can burn a hole, duh, no?) will reverse many symptoms of SIBO until health is restored. This is common in sedentary people and those with high insulin and food intolerances. Robb Wolf has a good working protocol for titrating Betaine Hcl -- we are outsourcing gastric acid until our stomach lining normalizes. All digestion starts in the mouth (salivation) and stomach (acid and mucus secretion). The small intestines will 'break' if these don't happen. It's delicate!
http://paleologix.com/hcl/


I've referred to the small intestines as being nearly sterile, but you are marvelously accurate. Compared to the large intestines which are teaming with anaerobic life, the small intestines have a relatively tiny but super important subpopulation.

It's not sterile at all. About 1000 to 100,000 organisms per mL mucus live in the small intestines. They persist despite the muscular 'housekeeping waves' of the MMC. The SFB have been imaged and in fact live nearly ON THE MICROVILLI, not in the slime. We have a symbiosis with them. When more than 100,000 organisms/mL live in the small intestines, then we are talking overpopulation and problems typically related to lack of gut SBO and commensals, high insulin, motility, parasites/pathogens, low gastric pH, lack of proper feeding and RESISTANT STARCHES, etc. Basically SIBO/SIFO.

Soil based organisms like SFB and other commensals are evolved to live in the small intestines (ILEUM) actually do crosstalk with our cells to produce things
--mucus
--immune cells
--modulate immune hyperactivity
--increase tolerance to 'self' including gut commensals
--decrease tolerance to 'foreign'
--two mouse studies now show SFB in the gut/ileum protect and reverse autoimmune disease models like Type 1 diabetes

The people who have GERD or bloating with fiber, RS, or probiotics are triggering the species that are growing inappropriately in the small intestines. This is not normal and it's called SIFO/SIBO (small intestinal fungal/bacterial overgrowth).

g

Anonymous said...

Hi Dr. BG,

Thank you so much for responding to me. I have read a lot on your website, but because of my fatigue, I tend to get overwhelmed with too much information easily.

Since I first posted to you, I started on the potato starch and psyllium. After the first tablespoon of the potato starch I had relief from the boating for two days, and was finally able to eat enough that I am finally gaining a little wait. I have had the opposite problem with all of the stress I have had. My adrenals were overdriven and I have a very difficult time handling much stress at all, and tend to lose weight very easily. However, the bloating came back again today although not as bad as it has been over the past couple of months since this started. Prior to that I was starting to feel better then I had in a very long time, (digestion was really good) but I think because of the adjustments they made to lower my hormone dose and diazepam added more burden to my system and I picked up some kind of virus that I have had a very hard time getting rid of. I am sleeping well with little to no anxiety now.....which is a blessing, but the fatigue is still horrible. I ordered the prescript Assist and I am doing sweet potatoes and rice a long with plenty of soups with lots of veggies, protein shakes with the amazing grass you recommended.

I did not see your email address...sometimes my brain skips, but is there anything else you might recommend other than what I have listed above?

I believe you are right about the endocrine disruption. It is very difficult for many to understand unless they have been through it, so thank you for the validation. I have no family and live alone, so the isolation has been difficult as my friends just don't understand how debilitating this has been for me. Going on four years now.

Let me know if you have other suggestions, and again......THANK YOU so very much! Your work here is a life saver for many I am sure.

Merry

Anonymous said...

P.S. Since you say I have endocrine disruption, should I be treating my gut problems that have mysteriously come up in the last couple of months the same as you recommend on the site with the things I mentioned. It appeared to be getting better than tonight it got much worse and I haven't been able to eat much.......I break out into these horrible sweats out of no where when my gut gets worse. I'm not sure what is appropriate for my situation. The website is informative, but some is very hard for me to follow for my specific case.

Thanks again!

Merry

Anonymous said...

Wow, DrBG, you've done your research! I'll have to read every blog article, every link and every comment here to absorb what you're saying. But I think you are absolutely right!

Yes, those pathogenic bacteria definitely accompany those autoimmune diseases. They're all the rage now and everyone's commenting on them (see Dan Littman and Diane Mathis). Unfortunately, our poor rheumatologists are all in the dark and think corticosteroids are still the way. I'm now taking Probiotics 3 (SBOs), GoL Primal Defense, and Prescript Assist along with 4 tbsps of RS, kombucha, sauerkraut, and beet kvass. Also 5 grams of pharmaceutical-grade L-glutamine to rebuild the gut lining (to allay intestinal permeability?)

Let's see if this fixes my Sjogren's! You're right on about that Minocen therapy for RA: it's way too strong! RA is one anomaly among connective tissue autoimmune diseases because it has an inflammatory component that's etiologically separate from autoimmune attack (molecular mimicry). I thought you are a "mere" microbiologist; how did you become so knowledgeable about autoimmunity and infections diseases, DrBG? My question is, howcome you haven't gotten an NIH grant yet to conduct your own clinical trial? Yes, I think Paul goes a little too far with his infection theory as far as autoimmunity is concerned; he seems to think lupus is entirely lyme-driven also.

My bold prediction: the road to curing autoimmunity runs through our gut microbiome. It's not just leaky gut, it's gut dysbiosis, another side of the same coin.

Also, I'm gonna go on a limb to say that a possible cure for T2 diabetes probably is via gut flora repopulation. Most T2 diabetics become seropositive for 1 of the 3 T1 antibodies temporarily while developing their insulin resistance.

Namby

Dr. B G said...

Namby~!

I appreciate all of your thoughts and insights. U ROCK. Actually your comments always make me cognate and think harder. Thx so much ;)

"Unfortunately, our poor rheumatologists are all in the dark and think corticosteroids are still the way." We have a healthcare crisis of epidemic proportions and MDs still hand out
bad, useless drugs like candy. I totally concur. Now with the microbiota studies, next they're be handing out antibiotics like there's no tomorrow.

My functional medicine friends call it 'Pharmageddon'. Sad. So unfortunate.

Thank you for all of your kind words! I am not that bright ;) I have amazing instructors and mentors. I believe in crowdsourcing and open source medicine. Let's spread the word out shall we?

People like Paul at PHD, Tim/Tater and Richard N/FTA can make huge differences in this world. Tiny steps but we are getting there. If non-trained civilians with no medical background can heal all the chronic diseases under the sun, what can that inspire in all of us? Can we cure cancer, Sjogrens, IBS, MS, brain infections, and others without pharmaceuticals (and I'm a pharmacist)??

You also said "My bold prediction: the road to curing autoimmunity runs through our gut microbiome. It's not just leaky gut, it's gut dysbiosis, another side of the same coin." I think your bold prediction is so true~!!!!


"Also, I'm gonna go on a limb to say that a possible cure for T2 diabetes probably is via gut flora repopulation. Most T2 diabetics become seropositive for 1 of the 3 T1 antibodies temporarily while developing their insulin resistance."

Absolutely. It's all auto-antibodies and the ICs (immune complexes) that 'clog' up our bodies, causing all sorts of chaos and confusion... Have you heard of Cyrex Labs and Vodjani? He was recently part of the Gluten Summit. He has done a lot of the relevant auto-antibody research, especially as it pertains to dysbiosis and intestinal permeability. He's a GENIUS.

I wasn't aware you had Sjogren's. Hope you feel better soon. Calming the immune system is imperative IMHO for Sjogrens and any autoimmune disease, in my experience. If you have dry eyes (that bleed), be careful and avoid those that may thin the blood excessively (biocurcumin, high dose omega 3 or vitamin E/tocopherols).

Thanks for your comments as always Namby!
G

Anonymous said...

Wait a minute. Did I hear correctly that both you and Tim had Hashimoto's AND cured it? I NEED you both!
I've been trying to heal for six years. Six years ago my special analysis showed very bad gut disbiosis. Since October I've introduced probiotics and fermented foods (sauerkraut, water kefir) into my diet and been taking mastic gum.
My results had been good but not a complete reversal of hashi's. 1 month ago I added in Biofilm defence.
3 weeks ago I added in Prescript Assist, with banana starch, psyllium, L glutamin, MSM and turmeric in 20 years of digestive problems I've not had the results that this bionic RS + SBO s has had. For someone who may not have a BM for 4 days and wouldn't be regular unless I took some rather serious bowel formulas (like Dr schulze's intestinal formula 1). I have had a BM EVERY day for the last 24 days (sometimes even TWICE!).
1 week ago I added in Oregon grape root, and peppermint tea + chanca piedra (for parasites etc).

I'm still getting immense pressure in my chest region and a type of reflux that I can't explain. It can be minutes or hours after a meal, I had a sudden pushing of air up, like I want to burp , but I've never burped in my life so my body just does this weird jerk when the air comes out! Strange huh?

I would dearly love to work with you on getting this done and dusted. It seems that both you and Tim are suggesting with the right protocol that the gut issues and therefore hashimotos can be reversed in a relatively short time,not the YEARS I read about others stating it takes.

I am eating 95% organic, meat veg, fruit and eggs. I cut out rice 4 months ago as my arsenic levels in hair tests were high, and I suspected the rice. I cut out nuts about a months ago. I just ordered Probiotic 3 and it will arrive soon.


Can I ask:
How long did it take you Grace?
How long did it take you Tim?
Did you have Milk kefir during this time? (I keep reading about the benefits of Milk Kefir, but the dangers or caesin if leaky gut is still present)
What extra measures would you take for nasty parasites or worms?


Can I contact you to work with you?
I keep reading that your email is on the left column, but I don't see anything here.
I've seen you put some type of blogger reference number I presume for contacting you, but I don't know how to use it.

I am so so so so so impressed with all I have read. This is what I've been looking for. Real people, with real protocols, and real results. Not the merry go round I've been on with doctors and naturopaths.
I'm in Australia so I'm happy to work with you via Skype or what ever or in conjunction with a practitioner here if need be.
I want to do the tests you recommend to get the most accurate information.

Sorry for long post, but you've got me so excited.

Many thanks,
Renee.

Tim Steele said...

Hi, Renee -

Grace's email can be found by clicking her name (Dr BG) in any of the comments above. Then you'll see an email link.

https://www.blogger.com/profile/15451872961651116061 (or try this)

I did not have Hashi's, just low thyroid. At least I was never diagnosed. I had a TSH level of 60 once, some would say that was definitely Hashi's but don't know.

I'm still taking Synthroid, definitely no Hashi's now. I'm on a very low dose (75mcg). My thyroid started falling in line once I started eating right, losing weight, and getting healthier. I was full-blown MetSyn and turned all that around in about 6 months.

As to you--I think you may experience a new level of health once you tie all this together and start taking the Pro-3 SBO's. Eat lots of fermented foods, like with every meal, even if it's just a few bites of sauerkraut or some yogurt.

Kefir is not a must. I've had it but not in a long time. If you like it go for it, water kefir is just as good for you--so is kvass. You need something, though, so find a fermented food you like (or a couple) and eat them very, very regularly.

Glad to hear about the BMs. That's the first sign you are healing you gut!

Hopefully Grace will jump in and answer the rest.

Anonymous said...

Thank-you so much Tim.
I can also report that my latest hair test results have come back in the low category for heavy metals - this is after over 6 years of highly toxic levels and being unable to rid them. Chalk one up to soil probiotics,water kefir, sauerkraut and kombucha! Score: Heavy metals - 0, good bacteria -1.
I've had cysts on my face non stop for the last 21 years and I've only got 2 tiny ones on my jaw now. If they keep subsiding at this rate, in 2 weeks I will have none (for first time in 21 years). This is the biggest clue that my internal inflammation is subsiding and it is very exciting.

How do I know when it is right to introduce some gut healing butter or ghee or lactoferrin or milk kefir? It's having casein while leaky gut is present I'm concerned about.

What about when to introduce nuts, eggs etc?

Your TSH was 60? Shuzzbut! Yep you probably were hashi's.

Thanks again for all your good work here and at Free the Animal. I've searched high and low for answers and tried everything and it seems the final nails are being driven into my illnesses coffin - thanks to Grace, yourself and Richard. Good riddance to Hashimoto's and all its associated problems.
Renee

Howie said...

Dr. BG and Tim, you guys are an awesome duo!

I've been taking my 4 tbs of PS/day with my whey isolate shake. I've seen tremendous lean mass gains the past month doing this, while losing some body fat. So I was curious to see if there were any studies looking at whey protein consumption and RS. I found an abstract here (http://digital.library.adelaide.edu.au/dspace/handle/2440/57517) that suggests that dietary protein increases the chance of colorectal cancer (in rats?) and that this risk is attenuated or reversed by RS. They specifically pointed out that plant and soy proteins still had some cancer risk with RS but that whey protein was not shown to have a correlation with colorectal cancer without RS (and RS was still great with whey, of course). Anyway, I was just wondering if you could speculate on the fact that whey and RS may be a super combination (maybe not yet researched) based on what you do know about RS and other papers you may have come across.

"DNA damage is an early step in the initiation of cancer and these findings agree with the population data which suggest that total dietary protein and red meat promote risk of colorectal cancer. However, inclusion of resistant starch in the diet could significantly reduce that risk. 2. Differential effects of dietary whey, soy and casein on colonic DNA damage and interaction with resistant starch The preceding experiments showed that high levels of animal-derived proteins increased colonocyte genetic damage and loss of the mucus barrier in rats. This second experiment was designed to determine whether diets high in different types of dairy protein (casein or whey) or a plant protein isolate (soy) had similar adverse effects on colonic DNA and mucus barrier function and whether inclusion of RS in the diet was protective. Adult male Sprague Dawley rats were fed a diet containing 15 % or 25 % casein, whey or soy protein, each with or without 48 % high amylose maize starch for 4 weeks. In confirmation of the earlier studies, higher levels of dietary casein increased colonocyte DNA damage significantly. However, whey did not increase genetic damage. Colonic DNA damage was highest for soy when fed at both 15% and 25% protein in the absence of RS. Inclusion of RS in the diet attenuated colonocyte DNA damage due to higher dietary protein in all three groups. The colonic mucus barrier was thinner in rats fed higher dietary protein but the effect was reversed by feeding RS. Caecal total SCFA and butyrate pools were low in rats fed the digestible starch and were higher in rats fed RS. However, there was no relationship between caecal or faecal SCFA and genetic damage or mucus thickness. Caecal and colonic tissue weight and colon length were higher in rats fed RS, consistent with greater SCFA supply. These data confirm that higher dietary protein of animal (casein) or plant (soy) origin increases genetic damage and loss of the mucus barrier indicating that this is an effect of protein and not its source. These findings accord with the epidemiological data which link dietary protein to greater risk of colorectal cancer and inflammatory bowel disease. However, the data show also that dietary proteins differ in their specific actions on genetic damage and mucus thickness. Further, the data from the feeding of whey suggest that not all proteins are equivalent in their capacity to provoke adverse changes in colonic integrity."

Tim Steele said...

Howie - Rat studies are sometimes hard to take seriously since they are so different from humans. But, I think that mixing PS with whey protein is a fine way to get it in ya.

I haven't looked into research specifically for this info, but there were a bunch of studies that showed RS cleared problems caused by a high red meat diet (in mice).

Good luck with what you are doing. Thanks for the report!

Howie said...

Thanks Tim. Hope you and Dr. BG are going to continue to collaborate on related topics.

April said...

I'm new to this. Have been reading for a while. I was following the Autoimmune Protocol by Ballantyne but it's not working for me. Have Hashimoto's and celiacs and have been to 13 doctors including just recently a naturopath. I'm broken physically and broke financially. I'm reading all this stuff and so sick and tired I can't wrap my head around any of it. I have been chronically sick for over 2 years but am only on Naturethroid thyroid meds. Can anybody tell me how to get started? I'm really lost here. I was eating white rice (and thought if was doing me good) until a friend told me it was high in arsenic. I don't know which end is up and I'm not computer savvy so ???? Anyone? What tests should I start with? I had 12 mercury fillings removed by a holistic dentist on 10-23-13 and haven't felt any better. Any suggestions will be appreciated.