tag:blogger.com,1999:blog-6780103924890350442.post2185631610526268185..comments2023-11-30T00:29:08.106-08:00Comments on Animal Pharm: Homo PurgareDr. B Ghttp://www.blogger.com/profile/15451872961651116061noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-6780103924890350442.post-64853973996973564432011-11-01T04:58:20.318-07:002011-11-01T04:58:20.318-07:00Thanks for the additional info re: metal toxicity ...Thanks for the additional info re: metal toxicity -- much appreciated! You really are fantastic. :)<br /><br />AlanaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-25698901239803985582011-11-01T01:36:45.759-07:002011-11-01T01:36:45.759-07:00Alana,
If we could clarify misinformation and red...Alana,<br /><br />If we could clarify misinformation and reduce the number of people taking the soma/koolaid... then it's a step toward a more enlightened world... I hope!<br /><br />Thanks for your questions! The best sources on minimizing metal exposure that I found is in fact from the WAPF foundation by Kaayla T. Daniel, PhD and Galen D. Knight, PhD. It is VERY THOROUGH. See below. It sounds like you discovered a mercury-free dentist but here's another link for mercury-free resources.<br /><br />http://www.westonaprice.org/soy-alert/soy-recovery-the-toxic-metal-component<br /><br />http://www.meetup.com/westonaprice-london/pages/Mercury_Free_Dentists/<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-76633958254008517362011-10-30T21:09:17.796-07:002011-10-30T21:09:17.796-07:00Dr. B G,
You are awesome. Huge thanks for the am...Dr. B G,<br /><br />You are awesome. Huge thanks for the amazingly thorough, thoughtful reply. Your take on things makes sense.<br /><br />I was curious about apoe4 fat intake because I found out I'm actually apoe4/4. I've found your and Dr. Deans' blog especially informative in researching apoe4 info, and am basically doing a Perfect Health Style diet and also trying to watch stress and sleep. (And knowing your stance metal toxicity, I've refused metal in my crown [went with porcelain], and no longer eat from metal lunch containers, but I'm not sure of other preventative measures to take.)<br /><br />Anyway, again, many thanks for your wonderful insight; your blog is a seriously valuable resource.<br /><br />AlanaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-80373187282236967832011-10-30T01:22:53.125-07:002011-10-30T01:22:53.125-07:00M,
Miss you TONS CHICKY :( Cyberspace isn't...M,<br /><br />Miss you TONS CHICKY :( Cyberspace isn't big enough...<br /><br />GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-58097915604922802052011-10-28T21:50:59.333-07:002011-10-28T21:50:59.333-07:00Hi, Love, good to see back in cyberspace, spreadin...Hi, Love, good to see back in cyberspace, spreading your thoughts and knowledge. - MMarisanoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-26422863923091171742011-10-28T04:51:12.481-07:002011-10-28T04:51:12.481-07:00Hi Alana,
Great question which I briefly addresse...Hi Alana,<br /><br />Great question which I briefly addressed in the prior apo E4/4 tagged posts. Like a lot of reduced fat ridiculousness out there, I believe the scientific conclusions are inaccurate and misinformed. Both the apoE book and Dr. Davis I believe are incorrectly concluding that reduced fat, high carb are the best for apoE4 in light of the nutritional science. In a study by Dreon, Krauss et al, it showed that indeed total LDL calculated is reduced with the reduced fat and high carb diet however this results in higher atherogenic, dense LDL particles. The LDL is quite lower but at the cost of LDL functionality and buoyancy.<br /><br />I don't buy into the false LDL-heart hypothesis. It is wrong. It widens people's waistlines, visceral fat (fatty liver/heart/pancreas) and shortens lifespans. The LDL-IV subfraction ('death band') is correlated to death, MIs, mortality in countless clinical trials. This is the best way to ascertain risk for both cancer, heart disease and any inflammatory condition (along with other markers like insulin, hsCRP, ANA, ESR, thyroid, cortisol, etc).<br /><br />High fat 46% of diet was dramatically better across each ApoE match compared with Reduced fat 24% of diet for LDL-IV, and particularly significant for apoE4 folks. Reduced fat diets (high carb) raises this dangerous marker LDL-IV the most. High carb and low saturated fat is absolutely dangerous for E4 and this is reflected in increased neural degeneration of the fattiest organ, the brain in Alzheimer's (diabetes type 3.0) and autistic/ASD individuals where E4 is prevalent.<br /><br />Table 4<br />LDL-IV, Sfo ['death band']<br /><br />E3/2 <br />high fat 10.7 ±3.3 <br />low fat 18.2±5.1 <br /><br />E3/3<br />high fat 10.9±1.4 <br />low fat 17.4±2.0 <br /><br />E4/3<br />high fat 11.8±1.5 <br />low fat 19.1 [**most suboptimal and lethal]<br /><br /><br /><br />HDL2 is another marker and the higher the better. Framingham showed this is the best marker for least mortality and anti-inflammatory status. The identical results were shown in Table 4 for HDL2: reduced fat worsened and high saturated fat produced the best subfractions, especially in the E4 allele carriers.<br /><br />Table 4<br />HDL2 [longevity biomarker]<br /><br />E3/2<br />high fat 43.5 ±13.6 <br />low fat 27.1±8.0 <br /><br />E3/3<br />high fat 36.0±4.2 <br />low fat 23.6 ±2.8 <br /><br />E4/3<br />high fat 35.3±5.2 <br />low fat 24.4 [** significantly suboptimal]<br /><br />Does that help? Diet determines many things and genetics can reveal the rest... It is misunderstood but this is precisely what I love about nutrigenomics. Obviously gluten grains are the most inflammatory but I believe any carbs for certain phenotypes and genotypes can potentially interact and only lab testing make it clear and obvious. Neurodegeneration, calcified arteries (CAC, carotid u/s) and fatty livers are target organ disease caused by inflammation (related to sdLDL). All reversible but would be nice to catch early rather than when causing detriment. These are being identified in children and young adults now...<br /><br />Let me know if I can provide better clarification! <br /><br />GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-36955558734830933372011-10-28T01:45:47.416-07:002011-10-28T01:45:47.416-07:00Citation:
http://atvb.ahajournals.org/content/15/1...Citation:<br />http://atvb.ahajournals.org/content/15/1/105.short<br /><br />Apolipoprotein E Isoform Phenotype and LDL Subclass Response to a Reduced-Fat Diet, ATVB. 1995;15:105-111.<br /><br />Abstract: We investigated the association of apolipoprotein (apo) E isoform phenotype with lipoprotein response to reduced dietary fat intake in 103 healthy men (apoE3/2, n=10; apoE3/3, n=65; and apoE4/3, 4/4, n=28). In a randomized, crossover design, subjects consumed high-fat (46%) and low-fat (24%) diets for 6 weeks each. High-fat LDL cholesterol differed among phenotypes, with apoE4/3, 4/4>apoE3/3>apoE3/2. Reduction of LDL cholesterol on the low-fat diet was greater for apoE4/3, 4/4 than apoE3/3 (P<.05). There was no significant change in plasma apoB level within any of the apoE phenotype groups on the low-fat diet. This result, together with measurements of LDL subfraction mass by analytical ultracentrifugation, indicated that the primary basis for the diet-induced reduction in LDL cholesterol was not reduced LDL particle number but rather a shift from large, buoyant, cholesterol-rich LDL particles (flotation rate, 7 to 12) to smaller, denser LDL particles (flotation rate, 0 to 7). The magnitude of this effect was related to apoE phenotype, with progressively greater reductions in levels of large LDL (P<.01) from apoE3/2 to apoE3/3 to apoE4/3, 4/4. These results indicate that reduced dietary fat lowers levels of large, buoyant LDL particles by an apoE-dependent mechanism.Dr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-53322449126907379582011-10-27T06:12:25.831-07:002011-10-27T06:12:25.831-07:00Dr. B G,
Enjoy reading your posts, as always.
Qu...Dr. B G,<br /><br />Enjoy reading your posts, as always.<br /><br />Question: I'm confused about apoe4 being meat/fat adaptive. I read elsewhere that apoe4's should eat lower-fat diets. Something about them not processing fat the way they should; any thoughts on that?<br /><br />Thanks as always for your insight,<br />AlanaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-56867857998324583712011-10-24T17:42:11.067-07:002011-10-24T17:42:11.067-07:00Dr. F,
Love ur funky name ;)
Thank you for your ...Dr. F,<br /><br />Love ur funky name ;)<br /><br />Thank you for your kind words. Crazy cat owners! <br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-68375587569980173242011-10-24T07:37:56.299-07:002011-10-24T07:37:56.299-07:00Love, love, love your kitten photos, Dr. BG. And ...Love, love, love your kitten photos, Dr. BG. And the line about practicing HIIT.<br /><br />Thanks for recommending grain-free cat food. I'm going to forward the suggestion to friends and relatives with cats. (Can you believe I know people who are trying to convert their cats to veganism? WTF?!?) While she was in your care, Angel ate better than a lot of people I know. Your kindness sets a good example.<br /><br />Dr. Funkenstein<br /><br />PS: Terrific presentation at AHS.Dr. Funkensteinnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-60454343581191109782011-10-21T17:09:28.362-07:002011-10-21T17:09:28.362-07:00YOU CR*CK ME THE F*CK UP.
Allo-wifery... *haa aha...YOU CR*CK ME THE F*CK UP.<br /><br />Allo-wifery... *haa ahaaa!!!* I'm not opposed.Dr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-42279507182113351892011-10-21T13:13:30.141-07:002011-10-21T13:13:30.141-07:00Wait, what just happened? Last thing I remember I ...Wait, what just happened? Last thing I remember I was reading something about multiple wives and boobs--then I woke up on the floor.praguestepchildhttps://www.blogger.com/profile/04219985675023163249noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-67538396732167306272011-10-21T08:16:47.885-07:002011-10-21T08:16:47.885-07:00Sean,
*sniffle sniffle* YUP.
Clearly adults ca...Sean,<br /><br />*sniffle sniffle* YUP. <br /><br />Clearly adults can't hold it in as well as kids... *ha*<br /><br />I like your 'over-commit the mother' thought. After 9months gestation + 2.5 yrs lactation, time to reboot the nutrient reserves for mom! I don't know chimps and oranguatans do it! OMG 7 YRS? Thank God we evolved!! A baby on a boob that long needs multiple boobs so hoorah for alloparenting but your idea for 'shutting off the gene' and the milk machinery just makes so much more sense for nomadic or mobile HG's. Hhhmmm, the idea for multiple wives/boobs does have merit, no? Most men agree *haa* As long as there is one that does laundry.<br /><br />GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-34267920959175974832011-10-21T07:00:29.105-07:002011-10-21T07:00:29.105-07:00I'm guessing there might have been a tear or t...I'm guessing there might have been a tear or two shed when you returned this ridiculously cute foster kitty? My kid would've definitely cried a river. <br /><br />Interesting you mention weaning and carnivores, I was just wondering out loud over on Richard's blog why lactose intolerance would've been so heavily selected for, it never really occurred to me to think about it, but there must be a reason for it. Why go out of your way (in an evolutionary sense) to shut off a gene like that? Because it stops being an optimal food or because it can over-commit the mother?praguestepchildhttps://www.blogger.com/profile/04219985675023163249noreply@blogger.com