tag:blogger.com,1999:blog-6780103924890350442.post4766169534002133663..comments2023-11-30T00:29:08.106-08:00Comments on Animal Pharm: HDL2b -- Age, Adiposity, Alcohol and EstrogenDr. B Ghttp://www.blogger.com/profile/15451872961651116061noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-6780103924890350442.post-41705325866588397292010-11-04T12:59:27.469-07:002010-11-04T12:59:27.469-07:00Ricardo,
OF COURSE!!! I like the DATA!!!! Thank ...Ricardo,<br /><br />OF COURSE!!! I like the DATA!!!! Thank you so much for the kind linkxxx~!<br /><br />I don't believe 80 yo have a statin deficiency and neither do obese, hyperlipid children or all adults... it's a hoax and snake oil to the utmost degree!!!<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-72210164089706510532010-11-02T17:24:06.798-07:002010-11-02T17:24:06.798-07:00Lipid-lowering treatment to the end? A review of o...Lipid-lowering treatment to the end? A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds. - http://www.ncbi.nlm.nih.gov/pubmed/20952373.https://www.blogger.com/profile/09917531397118353422noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-9432513670342758472008-09-07T09:16:00.000-07:002008-09-07T09:16:00.000-07:00John!I'm glad Larry helped the golf player -- that...John!<BR/><BR/>I'm glad Larry helped the golf player -- that is great! I haven't read the book yet but it sounds fantastic. I'd like to meet him too :) Going ketotic (I did not say DKA which is what traditional docs think of) has much value -- similar to intermittent fasting and reducing carbs minimally as an intermittent practice. Larry is right. Hot flashes are believed to be just an adrenaline rush (like diabetics who get hypoglycemic with drugs) to counter 'glucose starvation' in the hypothalamus in the brain.<BR/><BR/>I love krill oil. I wrote about <A HREF="http://drbganimalpharm.blogspot.com/search/label/Astaxanthin" REL="nofollow">Astaxanthin</A> which one of the major components of krill oil. I have personally witnessed amazing improvements in BP, intolerable joint knee pain and some improvements in HDL (probably HDL2/2b subfraction). Regular fish oil EPA+DHA should not be discontinued when krill/astaxanthin is started imo.<BR/><BR/>Yes -- the type of estrogen, fats and age relative to mense is very vital to make valid conclusions.<BR/><BR/>I don't know a lot about MCTs (so THANKS for the link). Lauric acid (12C) and the below (6-10C) are medium chained triglycerides and also known as 'SATURATED' fats. These have great anti-atheroclerosis and immunomodulating benefits. Somehow they promote more ketone body production as well (a phenomenal energy source in the brain -- and people on statins may not generate enough, I speculate). <BR/><BR/>This is from the UC Davis article:<BR/>ajcn.org/cgi/content/full/80/3/550<BR/><BR/>Caproic, caprylic, and capric acids<BR/>In bovine and human milk, caproic acid (6:0) is present at<BR/> 1% and 0.1% of milk fat, respectively, and caprylic acid (8:0)and capric acid (10:0) are present at 0.3% and 1.2% of milk fat, respectively. Goat milk contains the highest percentage of caprylic acid, at 2.7% of milk fat. These 3 fatty acids have similar biological activities. Both caprylic acid and capric acid have antiviral activity, and when formed from capric acid in the animal body, monocaprin has antiviral activity against HIV (76, 77). Caprylic acid has also been reported to have antitumor activity in mice (78). Negative effects of these fatty acids on CAD and cholesterol have not been a dietary issue.<BR/><BR/>Thanks as always!<BR/><BR/>-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-29369691354614526462008-09-07T03:24:00.000-07:002008-09-07T03:24:00.000-07:00Gyou can't get rid of me...Can you take a squizz a...G<BR/>you can't get rid of me...<BR/><BR/>Can you take a squizz at Michael's post but the comments are most interesting regarding MCT and menopause<BR/><BR/>http://www.proteinpower.com/drmike/ketones-and-ketosis/the-brain-trust-program-krill-oil-and-menopause/#more-999<BR/><BR/>My bias is , as you might guess, is that fats and hormone panel and age should be disclosed in the med papers.<BR/><BR/>Larry is a wonderful fella and helped me with a wonderful boy who had ADD that we love who is now playimg golf in Florida and hope to go see him one day..<BR/>B4N<BR/>jdr jhttps://www.blogger.com/profile/03137256472582167775noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-35756476265267497882008-08-31T22:15:00.000-07:002008-08-31T22:15:00.000-07:00Hi dr. j!I'll check out the girl website! T-natio...Hi dr. j!<BR/><BR/>I'll check out the girl website! T-nation is COOL. I read my husband's ummm... men's health journals for scientific purposes you know... for the articles. hee<BR/><BR/>I think I'm really lucky b/c the is audience is FAR MORE SMARTER... and funnier than me!! You're the s-a-v-a-n-t... I'm more 'idiot' most days... <BR/><BR/>You're right on about the mitochondria -- those microscopic powerhouses can make us or break us... I wonder what science you work on?Dr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-29776117165643881802008-08-31T16:58:00.000-07:002008-08-31T16:58:00.000-07:00g,you r fun.. maybe tell ur husband that the cocon...g,<BR/>you r fun.. maybe tell ur husband that the coconut scent is important to attract the dusky maidens from Polynesia , no forget that, i want them to come my way...<BR/><BR/>This muscle cell bizo is interesting stuff as it crosses over to my doc's passion which is "mitochondria biogenesis" ( good search term in pub med). Mayo Clinic recently published 2 papers showing that old and young endurance athletes have similar Mito activity which they attribute to the cell workout. <BR/><BR/>My heart doc focuses on mito efficiency as his view is that so many reactions take place there that the factory should be fed and operated at peak performance.<BR/><BR/>BTW, only in the interests of science, I do a lot of learning from these 2 sites ( for girls) http://www.figureathlete.com/<BR/>( and for boys ) http://www.t-nation.com/ .<BR/><BR/>The reason.... is ...let me think of a reason... someone once said to me when i was getting my head together about all this, "don't listen to dietitians etc, listen to body builders, coz they are the only ones who have to walk the talk".. not bad starting advice.<BR/><BR/>thanks for your blog,<BR/>its all such fun<BR/>johndr jhttps://www.blogger.com/profile/03137256472582167775noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-9227602466525687832008-08-31T13:53:00.000-07:002008-08-31T13:53:00.000-07:00Hey John,What a wonderful meal -- the breakfast of...Hey John,<BR/><BR/>What a wonderful meal -- the breakfast of TYP champions! <BR/><BR/>(My husband unfortunately is rebelling -- he thinks I'm feeding him sunscreen...(from the coconut scent))<BR/><BR/>Any reduction in body fat will improve HDL2 and particularly HDL2b. Dr. Davis does notice that sometimes initially HDL drop in the first 3-6mos with weight loss (but it may not all be HDL2). The same 'rebound' phenomenom is witnessed in children following an infection. HDL2 has powerful effects in binding gram-negative bacteria (and probably other bugs too) to negate/prevent proliferation and endotoxemia (fever, infection). Remember 'feed a fever, starve a cold...' <BR/><BR/>Change in body composition is more relevant imo than ultimately achieving some 'ideal' body fat or image. Personally 10-12% is really good for men. I think achieving appropriate lean mass (muscles) is actually more important than adiposity. But if body fat is 'high' then some downward trend needs to be happening in order for inflammation to be reduced. <BR/><BR/>I haven't quite reckoned it yet -- do people who look like the men in '300' the movie (naturally -- I'm saying without pharmaceutical assistance) do they have concomitant reduction in inflammation and dramatic rises in HDL2 and 2b?<BR/><BR/>I'm thinking... probably yeah... to look ripped and hot (the 'natural way')low carb/mod fat/mod-high protein with some intermittent fasting is the only way to go. Btw this is totally the TYP diet plan. Also the 'roids (testosterone and YAH even estrogen) released from muscle work/strength training are very very effective not only at reducing inflammation and increasing HDL2 out the roof.... but they also lower Lp(a). <BR/><BR/>Some individuals do better with higher dietary fat intake, depending on the type of baseline lipoprotein pattern exhibited, in my opinion. My TGs are naturally < 100 (even on HIGH HIGH carb) -- so I'm not one of these. I'll review my sat fat experiment some day. Or you can ask Peter -- he saved me $6k on cosmetic surgery... !! A degree of saturation of fat is HIGHLY HIGHLY HIGHLY necessary for life (and for upper body 'attributes' *wink*). <BR/><BR/>So...This is just anecdotal but those with TGs way way greater than 300-500s (even while 'low carb') probably benefit from the mod to higher fat intake more than the average person (like me -- too much sat fat just makes me... F A T ). There are some with an 'arachidonic acid' pathway malfunction. In these poor suckers, high fat may actually have deleterious effects (even if low low low carb). Why? I dunno. Our diet-gene interaction? I don't know if this is the case ALL THE TIME, but it appears so to me. <BR/><BR/>You're right... I hope we can have ways to precisely detect our optimal diet for our gene pattern some day. When we're 'result' driven though, it's pretty easy. Body fat is one good target. I'm aiming at HDL2 also. Ripped abs wouldn't hurt either, eh? Ripped abs and an Australian accent is gonna be a dangerous combination for you dude!<BR/><BR/>-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-21975247777712095262008-08-31T03:53:00.000-07:002008-08-31T03:53:00.000-07:00Dear G,Gee thank you so much for your post, it all...Dear G,<BR/>Gee thank you so much for your post, it all seems like an onion and you and Peter at hyperlipd and Dr Davis are peeling back the layers of knowledge .. but in the end i have to eat..so ( here's a giggle)after watching my researcher , my dog on the way she approached the order and relish in eating coconut oil vs fish oil I have switched to my/our pre run breakfast being 5gm of coconut fat and 3 gm of Jarrow DHA , a fried egg in non smoke point olive oil plus 5 almonds.. its quite hard switching to saturated fats. <BR/><BR/>the other issue is... Is there an optimum body fat value that is a worthy goal ? because it seems useful to me, the layperson, as a summation of many factors that include calorie excess and hormone infuenced metabolism etc. I have set a value of 10% being my goal , but would someone with 6% say, have a better lipid profile at the level of HDL dissection that you have done in your post?<BR/>best<BR/>john<BR/>austdr jhttps://www.blogger.com/profile/03137256472582167775noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-88950305895329066322008-08-30T13:38:00.000-07:002008-08-30T13:38:00.000-07:00Donny,Thanks for visiting (I think). You've broug...Donny,<BR/><BR/>Thanks for visiting (I think). You've brought up so many good questions! I dunno... I've wondered the S A M E things!<BR/><BR/>When I take niacin (Slo-Niacin) I do feel more calm sometimes (like when I used to smoke cigs/cigars which of course is the nastiest habit on earth and everyone should consider stopping if they are currently doing so). I wonder if i'ts activation on nicotinic receptors which are ALL OVER our cholinergic/CALMING nervous system? I don't know...<BR/><BR/>Absolutely I agree (and someday I'll make a big post on it) but any modifications on 'real' food or vitamin or fatty acid molecules usually doesn't work too well in the human body (and animal models) as well. Many examples exist, ie WHI, CARET, trans-fats, etc.<BR/><BR/>Studies with niacin actually have demonstrated large antioxidant capacity and as well as reduction in cancers. An anecdotal observation (which I haven't validated yet) is that those in the HATS trial on niacin did not have cancer (compared with placebo or simvastatin only). I'm not so sure about the benefits of niacinamide yet. Some forms of niacin don't work -- probably for the reasons that you cited.<BR/><BR/>I think you're right on about the mild fasting glucoses with niacin which is similar to (?excessive) low carbing -- maybe there's a corresponding 'reflex' cortisol or liver dumping effect? Again, haven't had a chance to delve into that one yet either. You've got too many ideas! You need to start blogging!<BR/><BR/>I also wondered about ketone bodies -- these are generated from the cholesterol synthesis pathway -- unfortunately Statins block this. I wonder if they block KB production to some extent as well? then we would certainly have a niacin-deficiency...<BR/><BR/>What's RQ, may I ask?<BR/><BR/>Thanks!<BR/>GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-52966824033670132262008-08-30T12:32:00.000-07:002008-08-30T12:32:00.000-07:00I've been wondering about niacin and longevity for...I've been wondering about niacin and longevity for a while now. My understanding is that Niacin encourages burning fatty acids as opposed to glucose. They've tried to prolong rodent lives with niacinamide, which improves blood sugar control, but it failed to prolong the lives. There was one altered form of niacinamide involving I think a ribose sugar molecule. But when you have to alter a vitamin to have a good effect, isn't there the possibility that some of the good effect comes from blocking the action of the original, unaltered vitamin? I spend most of my time kind of over my head on this stuff, so please excuse me if I've said any thing really stupid!<BR/> But nicotinic acid, on the other hand--I check this every once in a while, and I can't seem to find any longevity studies involving this. Maybe the fact that it can sometimes worsen blood sugar throws people? But if it does so by encouraging fat burning and decreasing sugar burning, causing the sort of "benign" insulin resistance you also get from a low carb, low insulin diet, it seems to me to be a pretty obvious place for researchers to look.<BR/> The other longevity study I really want to see is with a true ketogenic diet. With all the rodent studies with reduced tumour growth, reduced artherosclerosis, reduced alzheimer's-like symptoms, it just seems silly not to do this kind of study.<BR/> Low carb diet plus niacin to help keep your RQ low? They kept some worms alive longer than usual with some kind of sugar blocker. I wonder if niacin woulda worked?<BR/> That's my crank comment for the day. Thanks for blogging, it's always a good read.Anonymousnoreply@blogger.com