tag:blogger.com,1999:blog-6780103924890350442.post6035821651992525432..comments2023-11-30T00:29:08.106-08:00Comments on Animal Pharm: Auto-Tuning Lp(a): Value of Low Carb, High Sat FatDr. B Ghttp://www.blogger.com/profile/15451872961651116061noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-6780103924890350442.post-57558832938367631902010-07-07T05:05:17.487-07:002010-07-07T05:05:17.487-07:00It's going to get worse before it gets better....It's going to get worse before it gets better.<br /><br />http://carbwars.blogspot.com/2010/05/so-close.html<br /><br />Since then the ADA have aligned themselves with a bunch of other health "charities"<br /><br />http://www.diabetes.org/about-us/coalitions-and-collaborations.html<br /><br />so none of them can change their recommendatons unless they ALL do.<br /><br />Meanwhile<br /><br />http://carbwars.blogspot.com/2010/06/of-mice-and-men-and-usda.html<br /><br />I'm surprised at Mozzafarian, always regarded him as competent, but since Frank Hu went over to the dark side with Ron Krauss maybe he was ordered to redress the "balance" at HarvardAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-52687369126226993152010-04-10T19:25:18.521-07:002010-04-10T19:25:18.521-07:00How do you interpet this study: Posted: 4/4/2010 ...How do you interpet this study: Posted: 4/4/2010 6:45:33 PM <br /><br />--------------------------------------------------------------------------------<br /> <br />"With each 5% increase in the percentage of energy from polyunsaturated fats, there was a 10% reduction in the risk of coronary heart disease"<br /><br />" but the great majority of polyunsaturated fats in the diet, 90% to 95%, were omega-6 fatty acids."<br /><br /><br /><br /><br /><br />Replacing saturated fat with polyunsaturated fats—not carbs—reduces CHD risk<br />March 23, 2010 | Michael O'Riordan <br />Boston, MA - Replacing dietary saturated fats with polyunsaturated fats significantly reduces the risk of coronary heart disease events, a new study has shown [1]. The findings, say investigators, highlight the importance of replacing saturated fat with healthy food choices, such as fish and vegetable oils, in order to get the heart-protective benefits of a low-saturated-fat diet.<br /><br />"For 60 years we've been recommending reduced saturated-fat consumption without a focus on what should replace it in the diet," lead investigator Dr Dariush Mozaffarian (Harvard University, Boston, MA) told heartwire. "In practice, what's happened, if you look at trends over the past decade, saturated fat has been replaced by carbohydrates, largely refined carbohydrates. There have been several recent meta-analyses of observational studies showing that if you reduce saturated fat and don't pay attention to the replacement, there is no association with lower heart-disease events."<br /><br />Mozaffarian pointed to a recent meta-analysis of prospective epidemiologic studies showing that there was no significant evidence that dietary saturated fat is associated with an increased risk of coronary heart disease or cardiovascular disease [2].<br /><br />"This is pretty important on a policy level," said Mozaffarian. "It's naturally assumed that lowering saturated fat is good for the heart, but that's not what the evidence shows." Simply reducing saturated fat without regard to what is substituted for it might not derive any benefit, he said.<br /><br />The results of the study are published online March 23, 2010 in PLoS Medicine.<br /><br /><br /><br /><br />The average weighted consumption of polyunsaturated fats was 14.9% of energy consumption in the intervention groups compared with 5.0% of energy from the controls. The risk of MI and/or cardiac death was reduced a significant 19% for those who consumed more polyunsaturated fats. With each 5% increase in the percentage of energy from polyunsaturated fats, there was a 10% reduction in the risk of coronary heart disease.<br /><br />"We found that there was a significant overall benefit in using polyunsaturated fat as a replacement for saturated fat, and this benefit was about a 20% reduction in heart disease for the exchange the individuals made," said Mozaffarian. "Most of the trials used soybean oil or other vegetable oils that have a little bit of omega-3 fatty acids, but the great majority of polyunsaturated fats in the diet, 90% to 95%, were omega-6 fatty acids."<br /><br /><br />n<br /> <br /> This new study really confuses me as I was just getting more comfortable consuming more saturated fat. Plus, I thought it was best to avoid N-6 fats because they are pro-imflammatory.<br /><br />I hope you get back to me on this Dr. B.G.nightritenoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-23921434720592078942010-03-16T06:24:23.177-07:002010-03-16T06:24:23.177-07:00Concerning the cause of insulin resistance, I have...Concerning the cause of insulin resistance, I have also seen indications that fatty acid buildup in the cell is a factor. However, it would seem excess need to burn sugar is the main culprit. With high carb percentage in the diet, it would seem one would have to virtually avoid fatty acids and not eat so much fructose as to raise triglycerides. I have seen no evidence that a high-percentage fat diet with low sugar/starch lerads to insulin resistance.<br /><br />MurrayAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-25233620708803550702010-03-15T08:54:50.599-07:002010-03-15T08:54:50.599-07:00donny,
YOU are so bright. Redefining heart diseas...donny,<br /><br />YOU are so bright. Redefining heart disease and all neolithic conditions is:<br />--insufficient saturated fat (thereby knocking out apo E)<br />--excessive neolithic carbohydrates, gluten, lectins (thereby causing insulin resistance like TNFa knockouts, at the cell level)<br /><br />Celiacs (HLA DQ positive) are associated with increased granulation and keloid production (e.g. organ calcifications and intravascular PLAQUE). <br /><br />Collagen gone CRAZY.<br /><br />I think you deserve a Nobel...<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-45248588826431618362010-03-13T10:45:20.316-08:002010-03-13T10:45:20.316-08:00I think maybe I've defined atherosclerosis.
h...I think maybe I've defined atherosclerosis.<br /><br /><a href="http://naivenutrition.blogspot.com/2010/03/tumour-necrosis-factor-to-rescue-no.html" rel="nofollow">http://naivenutrition.blogspot.com/2010/03/tumour-necrosis-factor-to-rescue-no.html</a><br /><br />I need someone to tell me whether I'm crazy. :)donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-11648330916461220882010-03-09T16:53:29.703-08:002010-03-09T16:53:29.703-08:00http://www.jleukbio.org/cgi/content/full/83/4/804
...<a href="http://www.jleukbio.org/cgi/content/full/83/4/804" rel="nofollow">http://www.jleukbio.org/cgi/content/full/83/4/804</a><br /><br />"Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity"<br /><br />If visceral fat is an immune organ, an increase in visceral fat makes sense as a reaction to infection. So our bodies aren't trying to kill us.<br /><br />That study I posted above describes how visfatin, a hormone put out by visceral fat, recycles niacin. Which maybe puts some light on why niacin supplementation increases adiponectin (which decreases visceral fat.)<br /> <a href="http://www.medicalnewstoday.com/articles/133504.php" rel="nofollow">http://www.medicalnewstoday.com/articles/133504.php</a><br /><br />Okay, a little weirdness.<br /><br />"A biological tit for tat may hold clues to improving the success of islet cell transplants intended to cure type 1 diabetes, according to a Medical College of Georgia scientist. <br /><br />In type 1, the immune system attacks insulin-producing cells causing high blood glucose levels that may temporarily reduce the attack, said Dr. Rafal Pacholczyk, an immunologist in the MCG Center for Biotechnology and Genomic Medicine. <br /><br />..............<br /><br />High blood glucose, or hyperglycemia, causes all sorts of dysregulation throughout the body. "It throws off metabolism, hormonal interplay and increases the risk of severe infections," Dr. Pacholczyk said. A shot of insulin or an islet cell transplant normalizes blood glucose levels, enabling, among other things, restoration of the usual balance between effector T cells which mount an immune or autoimmune response and regulatory T cells which suppress attacks."<br /><br />Elevated glucose as an immune suppressor? I guess cancer loves that. Glucose levels in general as an immune modulator, maybe? Does physiological insulin resistance protect us from our own immune systems? Are type 2 diabetics more in need of this protection than the rest of us?donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-23963479440942764492010-03-09T12:19:48.104-08:002010-03-09T12:19:48.104-08:00westie,
Love your deep thoughts...
Trigs are fre...westie,<br /><br />Love your deep thoughts...<br /><br />Trigs are free fatty acids that go up with carbohydrate intake -- are these the fatty acids that you are speaking of that related to development of IR?<br /><br />I think you are RIGHT ON about our adipose tissue being dysfunctional, which is not really the way I have ever approached it... but fat is an organ. It's an endocrine organ -- releasing leptin and adiponectin. I didn't realize the macrophages were there to mop up dead adipocytes... this explains the massive chronic inflammation associated in certain obese phenotypes, esp those involved with chronic pain or mind diseases (bipolar, schizophrenia).<br /><br />IR at the liver level can be improved with MCTs and coconut oil. Long-chain omega-3s do as well clinical research shows. Why? PPAR agonism.<br /><br />You discussed synthetic PPARg analogues -- these do improve adipose. Where they fail are when patients continue to eat high carb (e.g. diabetes patients on the cr*ppy SAD AHA ADA diets...).<br /><br />PPARg drugs 'shift' visceral fat (good thing) to subcutaneous fat (ok thing). Not good in diabetics with concomitant high insulin, hyperglycemia. This raises the risk of death, MI and congestive heart failure -- which cancel out any marginal outcomes Avandia showed. DREAM was a nightmare -- Avandia killed double the patients (39 v. 22).<br /><br />The heart whose preferred fuel is fatty acids (like all 'slow twitch' myocytes) and when both carbs and a synthetic PPARg activity 24/7 all day in heart adipose stores are going on frankly the heart cannot remodel.<br /><br />NEJM talks more: 'Part I: Thiazolidinediones and Their Evolving Cardiovascular Implications'.<br /><br />I'd like to hear more of your thoughts on the immunity aspects of the adipose. Fascinating!<br /><br /><br />Thank you,<br />GraceDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-23424089857187595372010-03-08T23:37:01.752-08:002010-03-08T23:37:01.752-08:00"Would love to hear you expand on why carbs d..."Would love to hear you expand on why carbs don't cause IR!"<br /><br />I've beginning to think that there may be only one cause/mechanism for insulin resistance and that is increased fatty acid avaibility. Fatty acids blogs the mitochondrial oxidation of glucose. If you read or allready know how chronic inflammation or stress effects on our metabolic function you might understand what I'm thinking.<br /><br />Let's take for example PPARg agonists which restores abnormalities related to blood glucose regulation. It does it by directing fatty acids towards storage (triglycerides) and increase the number of adipocytes resulting more smaller adipocytes. <br /><br />PPARg agonism restores adipose tissue metabolic function and insulin sentivity etc. are seen as a result of that.<br /><br />I've tried to find an insulin resistant state that is not accompanied by elevated FFA's. <br /><br />I see visceral adiposity as a marker of problems in a adipose tissue function.<br /><br />Starch or glucose does have positive effects on lipid storage and they provide lot of energy for healthy metabolism. When adipocyte function is disturped glucose is not oxidized in the apidocyte mitochondria like in healthy cell. Large size of the adipocytes is a bad sign because it will lead to "inflamed adipose tissue" since when adiposytes grow too big they will eventually die and dying cells activates macrophages to clean the mess.<br /><br />Increased circulating FFA's will compromise liver function and eventually pancreatic cells will suffer and T2DM will become evident.Pasihttps://www.blogger.com/profile/03601391658285869058noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-4322209877142686552010-03-08T14:51:24.667-08:002010-03-08T14:51:24.667-08:00Hey Elizabeth,
I was surprised how much carbs win...Hey Elizabeth,<br /><br />I was surprised how much carbs wine -- either red or white have. Obviously, it depends on the winery and the fermentation. I learned wine has carbs first at Crossfit when Robb mentioned it (although he wasn't so much low carb at the time).<br /><br />If someone is really watching their carbs due to BG (blood glucose) fluctuations, then counting carbs from wine may make a big deal. On the other hand, wine has alcohol which <em>lowers</em> BG. Sake and other spirits even have nutrients in them that promote lower BP and vasodilation (beyond what alcohol dose). <br /><br />Too much alcohol can cause insulin resistance though I don't know the mechanism (probably involving the liver). So moderation is key. <br /><br />Tequila, norcal margaritas, vodka, sake -- no carbs at all.<br /><br />Hope that helps!Dr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-3899752271110762772010-03-08T14:05:54.246-08:002010-03-08T14:05:54.246-08:00donny,
Oh YEA -- Richard is Paleo king -- king of...donny,<br /><br />Oh YEA -- Richard is Paleo king -- king of immunity and king of all sorts of dental plaque and otherwise reversals!<br /><br />I believe he takes/uses pastured butter -- lots of K2 and stigamestrol (plant sterol) -- great stuff as well.<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-21557028527077781852010-03-08T14:01:48.933-08:002010-03-08T14:01:48.933-08:00donny,
Great points!!
Chronic bacteria exposure ...donny,<br /><br />Great points!!<br /><br />Chronic bacteria exposure and chronic LPS definitely could affect IR. Any chronic inflammation can. Perhaps this is why celiacs (who have the most 'leaky' gut) have more cancer and heart disease?<br /><br />Drugs that reduce TNF-a all the time reduce immunity. These drugs include the glucocorticoids (prednisone for example) and are associated with reduced defenses and immunosuppression against infections including flaring TB. Hence steroids are employed to reduce autoimmune disease, host-vs-graft disease and hepatitis. <br /><br />If think coconut oil, sat fat, vit D, and omega-3 all improve IR by a variety of mechanisms as you bring up <br />--reduce gut permeablility (hence less bacteria crossing, less LPS exposure)<br />--improve immunity TH1 TH2<br />--in vitro I think all have some antimicrobial action<br />--neural -- don't know how but I think they all improve the gut-neural link<br />--PPAR agonism this improves all the above and also improves IR in peripheral tissues (liver, muscles)<br /><br /><br /><br />Thanks!<br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-34072710488055228192010-03-08T11:06:13.081-08:002010-03-08T11:06:13.081-08:00Re: insulin resistance; endotoxins?
http://www.nc...Re: insulin resistance; endotoxins?<br /><br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC108207/<br /><br />"Lipoprotein(a) Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Mononuclear Cells"<br /><br />Peter's gone into this a few times. According to wikipedia, drugs that block tnf-alpha can cause inactive tuberculosis to turn into an active disease state. Reducing tnf and lp(a) by making it less necessary-- stopping endotoxins at the source?, vitamin d, fish oil, besides being heavy in saturated fat, coconut oil is famous for being anti-microbial, maybe that would work-- is Richard still the HDL king of Paleo? Is it a coincidence that he's also king of dental plaque reversal? <br /> Corn oil might kill some of the good bacteria, bacteria that are okay with corn oil would probably increase. Once you've got the wrong type of bacteria, glucose is no longer innocent.<br /> Glycine- also makes life difficult for some bacteria. (Candida loves the stuff, some people have to be careful.)<br /> Hdl itself can help mop up endotoxins-- but it tends to go up in scenarios where endotoxins should be less of a problem.donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-81156516296556558682010-03-08T07:47:41.858-08:002010-03-08T07:47:41.858-08:00HI there- I think I must be sounding like an alcho...HI there- I think I must be sounding like an alcholoic, another wine related question please; red or white? When you google them you get wildly different opinions on which has more carbs and impacts insulin more. Some say only red will do for low carbs, others say white is actually very low carb too.. what do you think on this? <br />Red is liable to give me black teeth and red shot eyes from the tanins. Although of course high in antioxidants etc<br /><br />Thanks, ElizabethElizabethhttps://www.blogger.com/profile/10507234874030906337noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-77275425576629167052010-03-08T06:48:34.805-08:002010-03-08T06:48:34.805-08:00Hi Neo,
Thank you -- ur a sweetie!! I've been...Hi Neo,<br /><br />Thank you -- ur a sweetie!! I've been thinking of brains for a while! I've ordered the book which looks so cool. Interesting how they might discuss minerals. <br /><br />The pain info is very interesting!!<br /><br />I've found the best n-6 info at Stephan's WholeHealthSource. Haven't read Sears latest 'Toxic Fat' bk but I imagine it is full of good references and insights just like the 'Omega Rx Zone' bk. (The diet is bunk imho b/c it's low sat fat and high carb, but the rest is good).<br /><br />I think ur blog is wonderful though I can't read it *haa*!!<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-1747659235284827392010-03-08T06:40:05.067-08:002010-03-08T06:40:05.067-08:00hey westie,
Really? Do you want to clarify?
Y...hey westie,<br /><br />Really? Do you want to clarify? <br /><br />You are correct -- I believe there are other factors attributed to IR -- smoking (in this subpop ~86% were smokers), hormone imbalance, PCBs (like found in seafood and inferior fish oil products), sedentary lifestyle, etc.<br /><br />Would love to hear you expand on why carbs don't cause IR!<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-48778160213775099852010-03-08T00:07:47.941-08:002010-03-08T00:07:47.941-08:00Lot of information in this post! Thanks!
You wrot...Lot of information in this post! Thanks!<br /><br />You wrote:<br /><br />"Intimal flaps were associated with:<br />(1) insulin resistance<br />(2) low HDL <br />(3) high total cholesterol <br />What lights up insulin? Carbs."<br /><br />It is a well known fact that insulin resistance causes HDL to sunk and add the number of tiny LDL but what causes insulin resistance?<br /><br />Not carbs. Carbs (glucose,starch) won't do you good if you are IR but they are not a causative factor for making you insulin resistant in the first place. Neither does insulin.Pasihttps://www.blogger.com/profile/03601391658285869058noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-67976153479561689812010-03-07T16:54:38.493-08:002010-03-07T16:54:38.493-08:00Thanks again, you have been such a bootylicious su...Thanks again, you have been such a bootylicious supercomputer of nutrition information - again!<br /><br />By the way, do you happen to know any good general book/article on horrors of linoleic acid for semi-lay person ? I have some serious motivation to write about n-6 related problems in finnish for my new paleo blog, yet the information floating in internet has seemed a bit hard to decipher so far.<br /><br />How about (for example) linoleic acid's possible effects on the nowadays insane use and need of NSAID's ? Dropping n-6 may lessen causes of inflammatory pain in various tissues ?<br /><br />I know Vitamin D has some power to do that which seems painfully clear after reading this (FULL report rocks!) :<br /><br />http://pain-topics.org/clinical_concepts/vitamind.php<br /><br /><br />On another topic, talking about fats and our beloved brains, I have long been interested in this intriguing book and hoped you would give it some reviewing when you have time:<br /><br />http://www.amazon.com/Survival-Fattest-Human-Brain-Evolution/dp/9812561919<br /><br /><br />This book simply rocks, it provides physiological/evolutionary basework for our critical need of iron, zinc, magnesium, selenium and copper and of course n-3 pufas. Fat is more than good - again ! :-)<br /><br />Just some random thoughts, keep on rockin' !Neonomidehttps://www.blogger.com/profile/00961709424324961929noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-6543907813196444882010-03-05T20:35:59.246-08:002010-03-05T20:35:59.246-08:00Anonymous,
Hormone imbalances affect our menses.....Anonymous,<br /><br />Hormone imbalances affect our menses...<br /><br />Read about thyroid and adrenals here:<br />http://www.westonaprice.org/Low-Metabolic-Energy-Therapies.html<br /><br />Read about estrogen and perimenopause from books by Dr. Uzzi Reis and Colgan PhD (see the bks on the sidebar).<br /><br />Since you are getting 'better' periods post-paleo and after the re-intro of dairy they reverted back to heavy, could it be the dairy?<br /><br />Sometimes I find strict paleo healthier for the great majority (including me). Even a small amount of dairy (if allergic) affects us, esp women for some reason. Omega-6 affects me MORE than most guys I know too (yea wtf not fair). Did you skip omega-3? Did you skip workouts? Did you gain weight? Did you increase omega-6 polyunsats unknowingly? These are the obvious factors that affect the ovaries in a short-time frame.<br /><br />Hope that helps! Try a month of dairy-free again... see if that is a contributing factor coz it usually is.<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-19188509294816271752010-03-05T06:21:10.124-08:002010-03-05T06:21:10.124-08:00off topic- posted this at paleohacks.com, but was ...off topic- posted this at paleohacks.com, but was wondering if you had any experience with this.<br /><br />-i just had a monster monster period after 6 months of progressively better ones. i did a few things differently this month like eat a little more cheese and take nyquil and aspirin for a cold, but i think, not sure, that what really did it was taking 1000mg of vitamin c for my cold. i read on the internet (i don't have the background to properly evaluate the source) that megadoses of vitamin c can increase estrogen. in the past when i've had heavier that my usual heavy periods (pre-paleo), it was because i took aspirin,, or maybe fish oil. has anyone else got a real heavy period after months of good ones? what do you think caused it?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-13590310195005679222010-03-04T12:25:51.798-08:002010-03-04T12:25:51.798-08:00Ned,
THANKXXX!!
-GNed,<br /><br />THANKXXX!!<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-3295509558570580592010-03-04T12:25:30.956-08:002010-03-04T12:25:30.956-08:00Sterling,
Unbelievably easy, huh?
Great tips a...Sterling,<br /><br />Unbelievably easy, huh? <br /><br />Great tips at ur blog! I don't have P90x yet but I think I'd will like it (coz I like the beach body series).<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-63898089332247973592010-03-04T12:24:06.541-08:002010-03-04T12:24:06.541-08:00donny,
Linoleic acid *blech!!* Recently I was c...donny,<br /><br />Linoleic acid *blech!!* Recently I was complaining to Seth about my carpal tunnel -- haven't had it in years but I am typing dramatically more this year (work, projects, etc). Stopped flaxseed and ate a bunch of pecans and almond butter (omega-6/LA). Halted my weight control -- like the article you posted. Worse -- I ahd carpal tunnel again. Flaxseed, more fish oil and stopping ALL omega-6 has done wonders and it's almost gone now.<br /><br />Tallow and leptin... please let me know when YOU figure it all out!!<br /><br />-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-36824319585332745142010-03-04T08:01:22.588-08:002010-03-04T08:01:22.588-08:00Hi Dr. B G, thanks.
Adiponectin levels do not rea...Hi Dr. B G, thanks.<br /><br />Adiponectin levels do not really start at the same level for both groups, which makes the graph a bit unclear. Looking at the actual numbers I think that, to better interpret the graph, it may be a good idea to simply ignore the first (white) circle at the zero mark on the vertical axis.<br /><br />What you pointed out about the omega 6 content is correct; definitely a possible factor. The positive results are either due to the high SFA, or the low omega 6 content (which was a whopping 7.2 g in the low SFA group), or a combination of both.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-31236784149705354122010-03-04T06:07:47.007-08:002010-03-04T06:07:47.007-08:00I've been telling my friends and family for 2 ...I've been telling my friends and family for 2 years that a high fat, high protein, low carb lifestyle is the key. It's the key to losing weight, staying lean, and bringing hormones back to homeostasis. Not to mention that excessive processed carbs are the culprit in obesity (leading to excessive calories of course), NOT fats from sources such as animals, coconut, olives, etc. Mix in some intermittent fasting and smart exercise and it's a recipe for a healthy, symptom-free life.Sterling Purdyhttps://www.blogger.com/profile/10758202573622623455noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-44216677453777512572010-03-03T21:46:34.982-08:002010-03-03T21:46:34.982-08:00http://www.springerlink.com/content/gm653220810165...<a href="http://www.springerlink.com/content/gm65322081016547/" rel="nofollow">http://www.springerlink.com/content/gm65322081016547/</a><br />----------------------------------<br />Abstract Obesity rates have dramatically increased over the last few decades and, at the same time, major changes in the type of fatty acid intake have occurred. Linoleic acid, an n-6 polyunsaturated fatty acid, is an essential fatty acid occurring in high amounts in several western diets. A potential role of this fatty acid on obesity has been suggested. Controversial effects of linoleic acid on insulin sensitivity have also been reported. Thus, the aim of this study was to examine the direct effects of linoleic acid on leptin and adiponectin production, two adipokines known to influence weight gain and insulin sensitivity. Because insulin-stimulated glucose metabolism is an important regulator of leptin production, the effects of linoleic acid on adipocyte metabolism were also examined. For this purpose, isolated rat adipocytes were incubated with linoleic acid (1–200 μM) in the absence or presence of insulin. Linoleic acid (1–200 μM) significantly decreased insulin-stimulated leptin secretion and expression (P < 0.05), however, no changes in basal leptin production were observed. Linoleic acid also induced a significant decrease (~20%) in adiponectin secretion (P < 0.05), but only in the presence of insulin and at the highest concentration tested (200 μM). This fatty acid did not modify either glucose uptake or lactate production and the percentage of glucose metabolized to lactate was not changed either. Together, these results suggest that linoleic acid seems to interfere with other insulin signalling pathway different from those controlling glucose uptake and metabolism, but involved in the regulation of leptin and adiponectin production. <br />---------------------------<br /><br />You can't tell, but I spat on the floor after I pasted that. Yuck.<br /><br />A prudent diet high in carbs and polyunsaturates might not be a good idea. I don't think a ketogenic diet based on omega 6 is a great idea either, but since replacing tallow with corn oil increases carbohydrate appetite (tallow is a leptin mimic, maybe. Palmitic acid?), that might not come up much.<br /><br /><br /><a href="http://naivenutrition.blogspot.com/2010/03/is-saturated-fat-beef-tallow-leptin.html" rel="nofollow">http://naivenutrition.blogspot.com/2010/03/is-saturated-fat-beef-tallow-leptin.html</a>donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.com