tag:blogger.com,1999:blog-6780103924890350442.post7437457968533251069..comments2023-11-30T00:29:08.106-08:00Comments on Animal Pharm: TYPs: Success To RegressDr. B Ghttp://www.blogger.com/profile/15451872961651116061noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-6780103924890350442.post-81717134455529952008-07-15T11:36:00.000-07:002008-07-15T11:36:00.000-07:00Hi Jean,There is a little disconnect from the micr...Hi Jean,<BR/><BR/>There is a little disconnect from the micro-cellular level to macro-vascular level. I don't understand biochem that well (sorry) but I do agree Palls' take on chronic stressors and use of 'broad spectrum' antioxidants in these 'inflamed' individuals. Definitely I'd agree that mitochondrial metabolism is KEY to many chronic conditions -- we throw them off by overconsuming carbs/fructose! Or by not exercising (which is a 'free' source of antioxidants) or not consuming enough dietary antioxidants when mitochondria combust fatty acids (the most potent energy source)!<BR/><BR/>It's funny the 3 protocols listed (below) include many of the elements found in TYP as well. He does mentioning <BR/>'lowering iNOS' with several antioxidants incl omega-3 and phosph...choline which we use often at TYP. Many brilliant minds converge at the same spot!<BR/><BR/>For CAD, consider the value of EBT heart scan to get a baseline and help you to target aggressiveness of targeted therapy. <BR/><BR/>My review of the literature shows that chronic fatigue and fibromyalgia are related partly to vitamin D (and fish oil) deficiency. Have you ever had your 25(OH)D level assessed? We target 60-70 ng/ml at TYP.<BR/><BR/>Hope that helps... G<BR/>+++++++++++++++++++++++++++<BR/>High dose hydroxocobalamin (B12) injections— potent nitric oxide scavenger <BR/>Whey protein—glutathione precursor <BR/>Guaifenesin—vanilloid antagonist? <BR/>NMDA blockers <BR/>Magnesium—lowers NMDA activity <BR/>Taurine—antioxidant and acts to lower excitotoxicity including NMDA activity <BR/>Betaine hydrochloride (HCl)—Betaine lowers reductive stress, the hydrochloride form should only be used in those with low stomach acid. <BR/><BR/><BR/>Flavonoids, including “bioflavonoids,” olive leaf extract, organic botanicals, hawthorn extract <BR/>Vitamin E (forms not listed) <BR/>Coenzyme Q10—acts both as antioxidant and to stimulate mitochondrial function <BR/>a-lipoic acid <BR/>Selenium <BR/>Omega-3 and –6 fatty acids <BR/>Melatonin—as an antioxidant that may act in the brain <BR/>Pyridoxal phosphate—improves glutamate/GABA ratio <BR/>Folic acid—lowers uncoupling of nitric oxide synthases <BR/><BR/><BR/>Magnesium as magnesium glycinate and magnesium malate—lowers NMDA activity—often uses magnesium injections <BR/>a-Lipoic acid—important antioxidant helps regenerate reduced glutathione <BR/>Vitamin B 12 IM injections, 3 mg injections (does not state whether this is hydroxocobalamin)—may act as potent nitric oxide scavenger <BR/>Eskimo fish oil—excellent source of long chain omega-3 fatty acids. Lowers iNOS induction, anti-inflammatory <BR/>Vitamin C <BR/>Grape seed extract (flavonoid) <BR/>Vitamin E, natural—does not state whether this includes g-tocopherol or tocotrienols <BR/>Physician’s protein formula, used as glutathione precursor <BR/>Zinc—antioxidant properties and copper/zinc superoxide dysmutase precursor <BR/>Acetyl-L-carnitine—important for restoring mitochondrial function <BR/>Coenzyme Q10—both important antioxidant properties and stimulates mitochondrial function <BR/>D-ribose—acts to increase rate of ATP and reduced glutathione regeneration <BR/>biochemistry. <BR/><BR/>Polyunsaturated phosphatidyl choline—predicted to lower reductive stress <BR/>Other phosphatidyl polyunsaturated lipids—this and the phosphatidyl choline are predicted to help restore the oxidatively damaged mitochondrial inner membrane <BR/>Magnesium—lowers NMDA activity, may aid in energy metabolism<BR/> <BR/>Taurine—antioxidant activity and lowers excitoxicity including NMDA activity <BR/>Artichoke extract—as flavonoid source? <BR/>Spirulina—blue-green alga is a highly concentrated antioxidant source <BR/>Natural vitamin E—does not tell us whether this includes g -tocopherol or tocotrienols <BR/>Calcium ascorbate—vitamin C <BR/>a -Lipoic acid—important antioxidant, key role in regeneration of reduced glutathione, but also has role in energy metabolism <BR/>Vitamin B 6—balance glutamate and GABA levels, lowers excitotoxicity <BR/>Niacin—role in energy metabolism <BR/>Riboflavin—important in reduction of oxidized glutathione back to reduced glutathione; also has important role in mitochondrial function <BR/>Thiamin—role in energy metabolism <BR/>Vitamin B 12—as nitric oxide scavenger? <BR/>Folic acid—lowers nitric oxide synthase uncoupling <BR/> <BR/><BR/>Dr. Neboysa (Nash) Petrovic<BR/><BR/>Valine and isoleucine—branched chain amino acids known to be involved in energy metabolism in mitochondria, and may be expected,therefore, to stimulate energy metabolism; modest levels may also lower excitotoxicity <BR/>Pyridoxine (B 6)—improves balance between glutamate and GABA, lowers excitotoxicity <BR/>Vitamin B 12 in the form of cyanocobalamin—cyanocobalamin is converted to hydroxocobalamin in the human body but the latter form will be more active as a nitric oxide scavenger, since it does not require such conversion <BR/>Riboflavin—helps reduce oxidized glutathione back to reduced glutathione <BR/>Carotenoids (alpha-carotene, bixin, zeaxanthin and lutein)-lipid (fat) soluble peroxynitrite scavengers <BR/>Flavonoids (flavones, rutin, hesperetin and others) <BR/>Ascorbic acid (vitamin C) <BR/>Tocotrienols—forms of vitamin E reported to have special roles in lowering effects of excitotoxicity <BR/>Thiamine (aneurin)—B vitamin involved in energy metabolism <BR/>Magnesium <BR/>Zinc <BR/>Betaine hydrochloride (HCl)—lowers reductive stress, hydrochloride form should only be used by those deficient in stomach acid <BR/><BR/>Essential fatty acids including long chain omega-3 fatty acids <BR/>Phosphatidyl serine—reported to lower iNOS induction (35,36) <BR/><BR/><BR/>Dr. Ziem <BR/><BR/>Nebulized, inhaled reduced glutathione <BR/>Nebulized, inhaled hydroxocobalamin (some use sublingual) <BR/>Mixed, natural tocopherols including g -tocopherol <BR/>Buffered vitamin C <BR/>Magnesium as malate <BR/>Four different flavonoid sources: Ginkgo biloba extract, cranberry extract, silymarin, and bilberry extract <BR/>Selenium as selenium-grown yeast <BR/>Coenzyme Q10 <BR/>Folic acid <BR/>Carotenoids including lycopene, lutein and b -carotene <BR/>a -Lipoic acid <BR/>Zinc (modest dose), manganese (low dose) and copper (low dose) <BR/>Vitamin B 6 in the form of pyridoxal phosphate <BR/>Riboflavin 5’-phosphate (FMN) <BR/>Betaine (trimethylglycine)Dr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-68824093743260236762008-07-15T11:15:00.000-07:002008-07-15T11:15:00.000-07:00Regarding l-arginine and increasing NO, how does t...Regarding l-arginine and increasing NO, how does the current theory of chronic fatigue (and others) fit in with this?<BR/>This is from Martin Palls' website: http://molecular.biosciences.wsu.edu/Faculty/pall/pall_main.htm <BR/>1.Short term stressors that initiate cases of multisystem illnesses act by raising nitric oxide synthesis and consequent levels of nitric oxide and its oxidant product peroxynitrite. <BR/> 2.Initiation is converted into a chronic illness through the action of vicious cycle mechanisms, through which chronic elevation of nitric oxide and peroxynitrite and other cycle elements is produced and maintained. <BR/> 3.Symptoms and signs of these illnesses are generated by elevated levels of nitric oxide and/or other important consequences of the proposed mechanism, i.e. elevated levels of peroxynitrite or inflammatory cytokines, oxidative stress and elevated NMDA and vanilloid receptor activity. <BR/> 4.Because the compounds involved, nitric oxide, superoxide and peroxynitrite have quite limited diffusion distances in biological tissues and because the mechanisms involved in the cycle act at the level of individual cells, the fundamental mechanisms are local. <BR/> 4.Therapy should focus on down-regulating NO/ONOO- cycle biochemistry."<BR/>This is all at the level of the mitochondria. Is there a resolution between your #7 and Dr Palls' theory?<BR/>I have had some heart issues and also fatigue issues which have not been resolved. Thanks for all the great info.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-34049994690180734342008-07-15T08:06:00.000-07:002008-07-15T08:06:00.000-07:00Thank you kindly!Thank you kindly!Dr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-6780103924890350442.post-42571494797791745862008-07-14T12:12:00.000-07:002008-07-14T12:12:00.000-07:00great post, full of great information!great post, full of great information!Unknownhttps://www.blogger.com/profile/11298778040201112664noreply@blogger.com