|Source: Miller, 1999|
Step #7 Heal hormones and immunity
Take adrenal support, liver support, antioxidants etc
(I use biocurcumin and berberine to combine with anti-microbials/anti-parasitics). This is particularly imperative for those with reactive hypoglycemia and BG crashes when they go longer than 3-4 hours between meals.
|Proposed Causes of Dysbiosis of the Microbiota|
Round, Mazmanian 2009
This is the final step in our 7-Step SIBO series! Thank you for joining Tim Steele (aka tatertot) and I on this fantastic discussion and opening conversations about our wonderous and fascinating GUT AND OUR MICROCRITTERS!
Has everyone seen Tim's GUTS OF STEELE and assayed via 16S PCR amplification at the American Gut Project???
- Resistant Starch: American Gut Project Real Results And Comparison (Very Big News) -- Free the Animal Post
By now, I hope you have an appreciation for the impact and difference one single organ as simple as the gut can affect our overall health, longevity, digestion and day-to-day brain function. More importantly, we dream that you feel more confident in identifying, addressing and fixing some of these intestinal issues.
I believe it is truly challenging to deal with all the modern factors that are the proposed causes of dysbiosis of the microbiota (see above)
-- low-grade gut infections (microbial overgrowths, parasites, etc)
-- unbalanced health and immune systems (lack of commensals -- Bifido, SFB, and soil based organisms)
-- our unique genetic vulnerabilities (e.g. HLA DQ2.5 for celiac; HLA B27 for alkylosing spondylitis)
-- lifestyle (lack of dirt exposures, stress, diet, sedentary atrophy, lack of sleep, livestock/dairy grade antibiotics, disjointed relationship with soil and farming)
-- early colonization of pathobionts (birth in hospitals, lack of breastfeeding, compromised maternal biota sources, toxic formula)
-- medical and dental practices (mercury amalgams, vaccines, antibiotics, hyperhygiene)
|Estimated Surface Area of the|
(no wonder we get so GI-f*kcered so easily)
Main Problem with the Small Intestines: GINORMOUS SURFACE AREA
Our small intestines are like head size -- very variable in size! As we grow, our small intestines grow as we age just like our height or head size. Much is perhaps determined by nutrition by mom and factors after birth. Our small intestines vary from 5 to 10 meters (average 6-7 m) -- 3-6 times our height. Indeed by surface area, our small intestines trump even our skin for being the largest organ in that regard.
In comparison, the large intestines is only a fraction of the length of the small intestines at ~1.5 m.
Unfortunately I believe this predisposes us mammals to inherent problems as we frequently encounter digestive disruptors such as all the ones listed above. These factors in our post-modern industrial neolithic age bombard us from pre-birth, birth and upwards.
I'm grateful that we have simple strategies and technology to address all of the gut disruptors -- fermented foods, whole grains/tubers/legumes, RS, potato starch prebiotics, soil based probiotics, diet, yoga, functional medicine lab testing GDX 2200 stool, ONE organic acids, Am Gut, uBIOME, etc.
|Small Intestines: 5-10 meters (~15- 30 feet)|
Large Intestine: 1.5 meter (~5 feet)
Source: NYU EDU SIBO
Mental stress directly impacts our gut function. The vagal nerve (see below) innervates our organs including the gut from head to tail. This nerve controls calm, cool, rest, repose and digestion. Look how the connections go between our brain to our gut, neat? 80% of our serotonin, the happy transmitter, are generated here. Melatonin, our sleep hormone, is then produced from serotonin. What is the first sign of stress? Insomnia, no wonder.
Who doesn't have stress? Widespread cortisol dysregulation is documented in teenagers (Dr. Briffa).
|Vagal Nerve Innervations: Head to Tail (Butt)|
Gut Brain Adrenal Axis
What are the variety of stressors the human body experience?
--Sources of stress: gluten, pathogenic organisms, viruses, yeasts, dysbiosis (not enough acid, lack of commensals), GMO food
--Sources of stress: mental, physical, traumatic, intrauterine
--Sources of stress: perceived, mental, fear, lack of trust, senses (hear, smell, touch, feel, taste, sense), future fears, past fears
Effects of Stress Breaks the Gut
Stress (cortisol) reaks open our gut, makes the TJs (tight junctions) leaky, and abruptly even changes our gut flora to more pathogenic populations while reducing the numbers of the good flora like Bifido. Read more about the gut-breaking effects on the Gut-Brain-Axis HERE.
Let's take surgery as an example (top diagram). Being cut open by a surgical knife, bleeding, open arteries and veins are one of the most stressful procedures a person may endure. With any minor or major stressor, the adrenal glands must put out cortisol and adrenaline. With major trauma (surgery) or mental stressor, buckets of cortisol are secreted to maintain homeostasis, blood glucose, heart rate, blood pressure, hormones, etc.
In different gut disorders and SIBO, slightly variable nervous system effects are observed. Some conditions are more 'turned up' by the sympathetic nervous system (SNS/adrenaline/cortisol) than others. Some conditions are more deficient or defective in the parasympathetic nervous system (PSNS/calm/oxytocin) than others.
How do you balance?
Adrenal Botanicals and Yoga
In both clinical practice and in studies, certain rhizomes, tubers, and herbs are shown to buffer and balance the function of the adrenal glands. Recently Robb Wolf and Chris Kresser talked about adrenal function. Prior animal pharm ADRENAL posts. The funniest physician on adrenal and hormone health is DR. SARA GOTTFRIED! Love love love this grrrrrl.
My favorite brand of adrenal support is by Gaia Adrenal Health but many exist. What works for you? How do you know when your adrenals are f*kcered?
Yoga -- for me yoga is the best tool for putting the SNS to rest and to bring the PSNS back to up to snuff. I don't know why it works! There are studies but none explain the deep, contemplative, and restorative properties that I get when I'm regularly doing yoga. If you are in adrenal dysregulation, I'd highly suggest considering avoiding ALL Bikram and other extreme activities. The high heat and extreme form (90 minutes of high intensity sweating) is actually super detrimental for marginally functioning adrenals.
Other ways to tell if you're 'stressed' is FINGERPRINTS (hat tip: D'adamo). Our height of our fingerprint ridges may reflect our gut health microvilli height. We are aware that sometimes skin damage reflects gut damage and bacterial/fungal translocation and their respective toxins (acne, rosacea, psoriasis (and here), eczema, etc). More damage, flatter villi, flatter fingerprints.
In celiac, with severe SIBO, see the white lines and flatness of the ridges? On a gluten-free diet, these improve.
|Figure 2 (white lines on gluten/celiac) versus |
Figure 3 (diminished white lines on gluten-free diet)
Source: David TJ et al, 1970
Small intestinal length: a factor essential for gut adaptation.
Weaver LT, Austin S, Cole TJ.
Gut. 1991 Nov;32(11):1321-3.
The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. PDF free.
Collins SM, Bercik P.
Gastroenterology. 2009 May;136(6):2003-14.
Therapeutic considerations of L-glutamine: a review of the literature.
Altern Med Rev. 1999 Aug;4(4):239-48.
Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation.
Clerc P, Young CA, Bordt EA, Grigore AM, Fiskum G, Polster BM.
PLoS One. 2013 Nov 13;8(11):e79982.
Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism.
Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, Salim Rasoel S, Tóth J, Holvoet L, Farré R, Van Oudenhove L, Boeckxstaens G, Verbeke K, Tack J.
Gut. 2013 Oct 23.