Tuesday, September 16, 2014

Don't Take Resistant Starch Alone and Other Precautions; RS2 Needs to Be Taken With Other Fiber To Spread Fermentation Completely Across the Entire Colon


"There were substantial differences between W-HAW and the other RS types. Changes in SCFA and pH were distributed more evenly through the large bowel in rats fed W- HAW. This may be of some value, because most chronic large bowel disease (including CRC) is localized in the distal colon and rectum, where SCFA supply is lowest (44). It has been suggested that a combination of RS plus nonstarch polysaccharide (NSP) is optimal in ensuring the supply of SCFA to these viscera (45). Our data support this, because HAW contained both fiber polysaccharides integrally, whereas the other diets (apart from W-LAW) required the addition of fiber."  Conlon et al, 2012.

W-HAW = Western diet, high amylose wheat [no, I'm not advocating wheat]
W-LAW = Western diet, low amylose wheat
NSP = non starch polysaccharide [all other fiber except RS]
RS = resistant starch


About a year ago I talked about the importance of the entire fiber spectrum and did my first post on #RESISTANTSTARCH lol. Below are other relevant RS posts:



Cooked RS3 Helped Heal My Gut

Cooked RS3 helped heal my gut along with soil probiotics; they allowed me and my kids to tolerate dairy and gluten again. I like it and it's a fantastic tool. It's the anchor of the 7 Steps.

Source: Fermentation of non-digestible oligosaccharides by human colonic bacteria
Gibson et al, 1996


Average Daily Fiber Estimates
8-40 grams RS
8-18 grams NSP
2-8 grams Oligosaccharides
2-10 grams Unabsorbed Sugars
3-9 grams Protein, Peptides


Rebiosis to Heal the Gut

In healing the gut, rebiosis needs to occur -- reintroduction of lost life to a dysbiotic terrain. Nearly all health conditions being studied are now emerging with correlations to intestinal dysbiosis. And as we know by fixing dysbiosis, we can resolve many health conditions from allergies to autism spectrum to hypertension. Weeding, seeding, breeding and feeding are part of this cycle of rebiosis.

The loss of our microbial 'limbs' in the gut can likely be attributed to 5 main factors:

(1) altered births: mothers that lacked commensals, C-section birth, use of formula

(2) widespread use of antibiotics in healthcare and poultry/livestock

(3) sanitation and modern food supplanting foods that were teeming with microbes before (food, processed pickles, hands, water/soil, fecal contaminated drinking water, etc)

(4) pollution and toxins -- mercury, arsenic, xenoestrogens (do you have moobies?), etc

(5) distance and disconnection from the soil, good dirt teeming with microbes and unmolested by herbicides, pesticides, steam treatment, synthetic chemicals or petrol based fertilizers



Cooked RS3 is Ancestrally Derived

I think RS is a foundation fiber that our grandmothers forage and fired up on ancestral coals, primitive ovens and later village hearths. I think our ancestral mothers and caregivers fed all varieties of tender and tasty tubers, starchy roots, rhizomes and corms to toddlers and teens along with berries, stems, leaves, seafood and meaty bones.

RS3 and RS2 are vastly different in our guts. They feed different populations and even anatomically act differently in our gut tube.

RS3 acts like insoluble fiber, carrying fermentation way until the distal end of the intestinal tube, whereas RS2 acts like kindling, burning hot and quickly at the intestinal gateway, the caecum. Alone, raw resistant starch granules are rapidly eaten by intestinal flora and leave no residual to be fermented at your butt/rectum unless insoluble fiber and/or cooked RS3 are included at the same time in the diet.

Gut researchers Conlon, Topping and their team (above) discuss how their data supports that RS2 (high amylose maize) cannot supply butyrate or other SCFA to the distal gut without the mechanical structure of insoluble fiber, such as that found in wheat, wheat bran and insoluble wheat fibers [and again, no, I'm not advocating gluten or wheat].

I think a lot of people are benefiting from green banana flour and raw potato starch -- all fantastic sources of RS2 --  but make errors in trying to supplement a high RS2 dose or a dose that is deficient in supplying fuel and structure for the entire gut. The non-RS2 microbial eaters starve and eventually become extinct or become weak and outcompeted. They even lose their functionality in degrading different plant polysaccharides according to data about Ruminococcus bromii, the keystone degrader for both RS2 and RS3. According to Ze et al, at least 25% of healthy controls don't have R bromii or have defective R bromii that cannot use or eat resistant starch. TWENTY-FIVE PERCENT ARE F**KCED? Yes and what about the unhealthy? The obese? The pre-cancerous? The cancer survivors? The ones who took 6 months of antibiotics for acne or Lyme disease? The ones who have been following longterm Paleo? Strict AIP? Or ketotic very low carb (very low fiber/RS) diets? Or on one or couple courses of antibiotics for sinus infections, colds, fevers or urinary tract infections? The ones on acid blockers like H2 receptor antagonists or the "purple pill" PPIs?

Is your R. bromii 50% f*kced? 75%? 85%?? I dunno. Probably a lot if you don't have healthy dirt, livestock exposures or soil-based organism type probiotics to replenish their inherent functionality.



Other precautions:

+  Don't take green banana flour or potato starch alone without insoluble plant fibers or cooked resistant starch (eg brown rice, beans, lentils, whole cooked tubers, carrots, 3-5 servings fibrous vegetables or fruit)

+  Don't take green banana flour or potato starch at high dose without the entire plant fiber spectrum for a long period of time: inulin, oligosaccharides (eg onions, leeks, chives, yacon root, Jerusalem sunchokes, asparagus, inulin supplementation, etc). You may likely skew your gut populations.

You may starve and kill these tender and immunoprotective populations:
     --Bifidobacteria (many species just do not eat raw RS2; yet all eat cooked RS3, inulin, oligosaccharides, other fiber)
     --Enterococcus
     --Lactobacillus (none eat RS2; all eat cooked RS3)
     --Good E coli



The F-Word: F*BER

Get the range of 'fiber', RS and plant/meat glycans:

Milk Oligosaccharides - the carbohydrates found in raw cow, sheep, goat and human breast milk, dairy products and fermented soft and hard cheeses.

- Resistant Starch (RS) - the most common storage carbohydrate of plants. Found in tubers, roots, green bananas, green plantains, legumes, peas, oats, nuts, carrots, maize, sedge nutlets, and grains.

- Inulin and Oigosaccharides (OS)  - (inulin, fructo-oligosaccharides, galacto-oligosaccharides, xylo-oligosaccharides) the second most common storage carbohydrate of plants including chicory root and its greens (aka endive), onion, leek, yacon root, Jerusalem artichokes, dandelion leaves and roots, asparagus, ripe bananas/plantains, legumes, lentils, oats, whole rice, red/black/purple rice, maize, grains.

- Non-Starch Polysaccharides (NSP): (found in small and large amounts in nature)
Arabinogalactan - a storage carbohydrate of trees and many plants (carrots, radish, black gram beans, pear, maize, red wine, tomatoes, sorghum, coconut meat)
Arabinoxylan - found in whole grains, psyllium, steel cut oats
Glucomannan - found in the cell walls of certain plant roots and wood, also a component of bacterial and yeast membrane. Konjac roots contain 40% by dry weight and are a great source of glucomannan
β-Glucans - found in oats, barley, whole grains, shiitake, oyster, maitake, mushrooms, dates, yeast
Pectin - found in avocados, berries, citrus, fruits, vegetables
Gums and mucilages - found in seed extracts (guar, locust bean), tree exudates (gum acacia, algal polysaccharides (alginates, agar, carrageenan), psyllium



Man-made prebiotics derived from plants and animals:

Galacto Oligosaccharides (GOS) - derived from cow’s milk to simulate human breast milk for infant formula. Dr Bill Lagakos favorite by UK Bimuno!  
Fructo Oligosaccharides (FOS) - separated from natural inulin, used in sweeteners.
Mannan Oligosaccharides (MOS)- made from yeast cells, approved only for animals.



Potent but powerful prebiotics:

Polyphenols and Flavonoids - found in many places in trace amounts; colorful plants, dark chocolate, seaweed, and mushrooms. Red wine (but not gin) raises Bifidobacteria.
Glycans and glycolipids - Found in raw meat, raw blood, cartilage, gelatin, collagen, chondroitin, and animal cells.
Chitin and chitosan - found in fungi, yeasts, insects, worms.

Thursday, September 11, 2014

Immunoprotection of Bifidobacteria and Vaccine Injury: The Biological Plausibility of Microbial Predisposition, By Keith Bell (Green Med Info)

Earlier I had posted a science-driven presentation by Dr Tetyana Obukhanych, Ph.D. on Natural Immunity and Vaccination. She reviewed the literature (scanty) on the efficacy of herd immunity and the fallacies of protection, specifically how mothers are not conferring full and complete immunity against rare, but devastating whooping cough and measles to their newborns when breastfeeding. This is not ancestral and may have consequences. Additionally she reviewed the potentials of vaccine injury, including gut dysbiosis and multiple food allergies (peanut, gluten, dairy).


Green Med Info just published an article written by the knowledgable and brilliant student of the gut, Mr Keith Bell: Vaccine Injury: The Biological Plausibility of Microbial Predisposition

Page 1 (GREEN MED INFO)

You may not have heard the news due to media censorship of the vaccine-autism debate, but apparently childhood vaccines can and do cause autism. Last month, a CDC Senior Scientist issued an apologetic press release admitting data omission from a 2004 study.  The ditched data suggested African American boys are at increased risk of autism when given the MMR vaccine.

CDC's Director of Immunization Safety, co-author of the fraudulent 2004 study, has also admittedvaccines can result in autism.  Moreover, autism is listed as side effect in the DTaP vaccinepackage insert.

Brian Hooker received the CDC confession directly from Senior Scientist, William Thompson. Hooker reanalyzed the data and found a 2.4x increased risk of autism in African American boys. The CDC states a lack of biological plausibility, but there's plenty.
Why would certain children be vulnerable to autism or any vaccine injury such as tic and seizure disorders? What makes them different from others who somehow escape injury?
First let's address gender inequality. Boys are up to five times more likely than girls to become autistic, perhaps because estrogen is crucial to immune response. Girls are primed at birth. But why African American boys? How tragic that over ten years ago the CDC decided this wasn't important enough to study further. How many African American boys have been damaged?

Other populations at risk of autism by vaccination include Koreans, Somali immigrants, perhaps much of Africa and Caucasians, too. Somali immigrants of Minneapolis and Sweden suffer high rates of autism when there is no word for "autism" in Somalia. In Sweden, they call it "Swedish disease."

Everyone on Earth is vulnerable to vaccine damage, but some populations appear especially at risk. These groups are different than others based on generations of dietary habits resulting in the underlying beauty of diversity: microbial predisposition. Their flora is naturally different!

Scientists have found gut microbiota play an important role in how well vaccines are absorbed. Imbalanced flora leads to vaccine failure. In sanitation-challenged, toxic nations such as Pakistan, for example, the polio vaccine can be ineffective due to compromised guts known asenvironmental enteropathy. How ironic that if we made sanitation and toxic pollution a priority, we could also reduce vaccination and its risk of injury. Instead, children suffer malabsorption syndrome misdiagnosed as malnutrition. They can't properly absorb nutrients or vaccines. Meanwhile, less than 2% of Bill & Melinda Gates Foundation budget goes toward improving sanitation; the lion's share toward vaccination in concert with major pharmaceuticals andGAVI. The United Nations, UNICEF and the World Bank promote wastewater treatment without any priority on the real solution of dry toilet technology.

One of the differences is reduced or absent bifidobacteria.


According to a Bangladeshi microbiota study published last month, poor vaccine efficacy is associated with systemic inflammation due to gut dysbiosis. Bifidobacteria were found a key factor in improving vaccine responsiveness. There are many known strains of bifidobacteria, some considered better than others. Bifidobacteria levels in the USA vary widely among individuals. Studies report much lower levels of bifidobacteria in children with autism.

Vaccine scientists are focused on improving vaccine absorption, promoting probiotic adjuvants. Bifidobacteria appear to have a leading role as future adjuvant.  But this work may also reveal a mechanism of vaccine injury: lack of an important species. Bifidobacteria are known to attenuatesevere intestinal inflammation. One study found their numbers naturally multiply in magnesium deficiency to calm inflammation.
Many Africans are missing bifidobacteria. And so are Koreans where autism rates were founddouble those in the USA. The traditional diet of these populations doesn't include dairy, which feeds bifidobacteria. It should be noted not all Africans are reduced or absent in bifidobacteria. Onestudy found bifidobacteria far more dominant in Malawian than Finnish infants while another studyfinds eightfold autism increases in Finland. Another vulnerable group appears to be vegans and vegetarians, known significantly reduced in bifidobacteria.

Breastfeeding is another important clue about bifidobacteria and autism avoidance. Breast milk is known to contain 700 types of bacteria with bifidobacteria the star of the show. Gerber includes bifidobacteria in their infant formula for good reason as "they make up 80–90% of the total intestinal flora of breastfed infants." Several studies indicate breastfeeding deters autism. What's not commonly recognized is how microbes both produce and stimulate release of fatty acids in breast milk crucial to brain development. These lipids include endocannabinoids now making waves in the epilepsy community (seizure is a common feature in autism).

A new study reinforces what's known about the global C-section epidemic and neurodevelopmental problems including autism. A third of women give birth by C-section in the USA, exceeded by other nations such as China and Brazil. C-section is known to result indifferences in infant intestinal flora, but what are the actual differences and how might this relate to potential for vaccine injury? This group of scientists found significantly lower bifidobacteria counts in C-section babies than in vaginally delivered infants. The bifidobacteria, however, are thought to originate in the mother's intestines.


Page 2 (GREEN MED INFO)

Are girls higher in bifidobacteria than boys? Might this be another way girls escape autism? Recent studies reveal another way to view gender differences. Men and women can eat the same diet, but have distinctly different gut microbiota.
In the Hazda people of Africa, bifidobacteria is absent and so is dairy, however, some forms of resistant starch and inulin may also feed bifidobacteria. The Hazda microbiome is more diverse, so they don't require bifidobacteria. Other microbes are doing the job for their healthy human hosts, but perhaps not if confronted with vaccination.
Then again, the Hazda immune system may be better able to withstand vaccination than African Americans. The immune system is reliant on flora balance where gut dysbiosis, such as high clostridia, and low bifidobacteria counts may predispose a newborn toward vaccine injury. Alternatively, high clostridia counts known in autism may be the result of vaccination. Vaccines may lead to such imbalances, similar to antibiotics known to cause C. difficile infections.

The fact is there are still no studies about how any of the childhood vaccines affect flora balance. Why not? Does anyone fear the results? Solving this mystery may require crowdfunding. There are many complexities to be unraveled. How are mercury and aluminum adjuvants affecting flora? How might vaccine-induced immune responses affect flora balance?

There are a sparse few studies approaching the subject such as this 2004 study from China showing significantly increased gram-negative bacteria caused by the cholera vaccine, not a good thing. This 2013 typhoid vaccine study states:
"However, to date, no comprehensive studies have been undertaken to examine the gastrointestinal microbiota in relation to vaccine administration and if there is a discernible alteration in the community following vaccine administration."
How would a shift in flora or absent bifidobacteria lead to autism? This falls under the category of gut-brain phenomenon and probably begins in the womb. Dozens of peer-reviewed studies impudently state colonization begins at birth, a fallacy without evidence akin to believing Earth is flat. The new paradigm points toward a fetal gastrointestinal tract teeming with life, developing long before the fetal brain, even driving brain development with polyunsaturated fatty acids of microbial origin. The maternal microbiome shifts toward a diabetic state in the third trimester while the fetal brain triples in weight.

Children are born colonized and then vaccinated within 12 hours of birth per cruel CDC schedule without any understanding of how this affects flora balance. The gut-brain connection is a two-way street where what happens in the gut may lead to an inflammatory reaction in the brain.Bifidobacteria may be a factor in helping to avoid this reaction. Indeed, probiotics of many types have been tested alongside vaccines to improve vaccine response because it's known microbiotainfluence immune response. Might probiotics also help to avoid extreme immune response resulting in autism? Too many parents of autistic children have witnessed the arched back and high-pitched scream of their infants post-vaccination, a condition signaling brain inflammation.

I suspect bifidobacteria will become biomarkers to help avoid vaccine injuries. Every child would have microbial DNA (PCR) stool testing to determine flora balance prior to vaccination. If bifidobacteria are low or absent, this may serve as warning not to vaccinate. This applies to all children because everyone is at risk. Children may be born compromised with imbalanced flora where vaccines add insult to injury.

We should begin the process of reducing CDC vaccine protocol, beginning the protocol much later in life to allow the immune system, reliant on flora, time to develop. This would reduce vaccine injuries while improving vaccine effectiveness. Or, we can choose not to vaccinate and concentrate on improving innate immunity. Many believe our natural immunity is waning due to vaccination, so we're seeing a comeback of childhood diseases such as measles and mumps.

Either way, we need to reduce heartbreaking injuries as well as consider the subtle, insidious possibility of widespread flora shift in the wrong direction. We're already seeing mysterious childhood type-1 diabetes and obesity epidemics along with eating disorders such as anorexia in very young children. Half our children suffer chronic disease, an unacceptable situation where everyone is vulnerable based on flora balance.
Florida Congressman, Bill Posey, is investigating CDC fraud amid an incestuous relationship with the pharmaceutical industry. Contact your Congressman to ask support for Posey's congressional hearings to learn more about extent of damage. The CDC "whistleblower" may receive immunityfrom prosecution so that underlying truth may finally be revealed, just as microbial genetic testing is taking us toward a new understanding of our place in the environment. 

Keith Bell is a 25 year veteran of the recycling industry with interest in sanitation and health. During the 1980s, he was a UNICEF radio spokesperson in Chicago for the annual release of State of the World's Children Report. He’s particularly interested in gut-brain connection including gut-origin of seizure, underdiagnosed in epilepsy. Sanitation is Sanity poster 

Wednesday, September 10, 2014

The Sun Revolves Around the Earth...(18% of Americans still believe the Sun revolves around the Earth)

Seriously.

Many still hold beliefs against geoheliocentrism (kinda like the potential for vaccine injury and one among many reasons for possible subsequent gluten/dairy/food/peanut sensitizations and allergies... and epic gut disruptions, dysbiosis, metabolic problems, obesity...)

"Although virtually all scientists and most laymen now take Heliocentrism for granted, the human mind still has a tendency to accept and maintain any sense of closure it has already obtained based on seemingly obvious observations, rather than entertaining the possibility that those observations are misleading or entirely false. Consequently, a 1990's Gallup poll found that 16% of Germans, 18% of Americans and 19% of Britons still hold that the Sun revolves around the Earth, and a 2005 study found that one in five American adults still believe that. (Cited in Wikipedia’s entry for “Geocentric Model”)."

--Source

Tuesday, September 9, 2014

Dr Tetyana Obukhanych, Ph.D. - Natural Immunity and Vaccination





Dr Tetyana Obukhanych, Ph.D. - Natural Immunity and Vaccination

Ukrainian-born immunologist, Dr Obukhanych PhD is the author of Vaccine Illusion: How Vaccination Compromises Our Natural Immunity and What We Can Do to Regain Our Health. In her book, she presents a view on vaccination that is radically different from mainstream theories
Dr Tetyana Obukhanych, has studied immunology in has studied immunology in some of the world's most prestigious medical institutions. She earned her PhD in Immunology at the Rockefeller University in New York and did postdoctoral training at Harvard Medical School, Boston, MA. and Stanford University in California.

She does talks for mom groups, practitioners and WAPF groups. I just saw her in SF on Sunday. She's absolutely wonderful and super brilliantly sharp!

Her view on the science is clear, concise and complete. Her intention is to illuminate the science, not perpetuate the public health fears. Facts v. fiction. The goal of the talk is to review: the facts, the theories, the choices.

"Facts without theory are nonsense. And theories without facts are b*llsh*t."
--Dr Obukhanych's favorite stat professor at Stanford



In her latest talk, she discusses some immunoprotective strategies and their mechanisms in health:
--vitamin C
--vitamin A (her favorite is WAPF supported, fermented CLO, cod liver oil)
--vitamin D
--probiotics
--raw dairy, cream, raw eggs
--breastmilk as a shield for the baby and why (AHS14 The first paleo food: Breastmilk and it's alive! Speaker: Dr Goscienski MD)


Monday, September 1, 2014

Neanderthals Mingled for Millenia

There is a new article in Nature about Neanderthals. My previous posts on them: here. I think they're an interesting group which overlapped with both Hss and Homo erectus (aka Java Man, aka Peking Man). I talked a ton about Homo erectus at the AHS14 talk because though we do not apparently have DNA data yet, he had such range and geographic breadth like Neanderthals, that there certainly likely existed co-mingled culture and blood between Hss and Homo erectus. New evidence appears to indicate we shared many things with Neanderthals for several thousand years... and their demise appears staggered over geography and time. I still wonder what diet, lifestyles and climate changes affected their extinction? They were cold adapted, surviving Ice Ages and interglacials. They grew rapidly during maturation and development, even more than there predecessors, almost like a vampirish subspecies. But, apparently something in the warmer climates laid claim to their eventually deaths as an independent native race. It's still a mystery. Too bad gut and intestinal tissues haven't survived the millenia for sophisticated analysis.



The timing and spatiotemporal patterning of Neanderthal disappearance
Part of abstract: The timing of Neanderthal disappearance and the extent to which they overlapped with the earliest incoming anatomically modern humans (AMHs) in Eurasia are key questions in palaeoanthropology1, 2. Determining the spatiotemporal relationship between the two populations is crucial if we are to understand the processes, timing and reasons leading to the disappearance of Neanderthals and the likelihood of cultural and genetic exchange.



Editor's summary
Did anatomically modern humans coexist with Neanderthals? Attempts to answer this question are complicated by the fact that conventional methods of radiocarbon dating become unreliable at just about the time in question: as sample ages approach 50,000 years little carbon-14 is left and it is difficult to obtain accurate measurements. Tom Higham and colleagues have worked to improve sample processing and accelerator-mass-spectrometry radiocarbon dating in order to construct a robust chronology based on the last appearances of the Mousterian tool culture — considered diagnostic for the presence of Neanderthals — from forty sites from Spain to Russia. The results indicate that Neanderthals disappeared at different times in different regions, with a significant overlap with incoming modern humans for around 2,600 to 5,400 years. Rather than a rapid model of replacement, this work suggests a complex picture in which cultural and biological interchange could have occurred between the two groups across a period of several thousand years.

Friday, August 29, 2014

Exercise (Step #6) to Be Lean, Healthy, HAWWWT, Have a Great Gut and GUT MICROBIOTA; New Study on Spectacular Diversity, Health Markers, and Guts of Elite Irish Rugby Team

IRISH RUGBY MEMBERS
Source
Exercise (Step #6)

Did you guys see how a new trial showed that the studly, elite rugby players on the national Irish team displayed awesome guts (and abs) while they were in training? I love this topic because not only does it raise many questions but it may answer what we inherently know/suspect about the interweaved relationship between good health and lifestyles/diet/exercise AND GUT HEALTH.

Exercise is Step #6 of the 7 Steps for optimal gut health and super bionic fiber combo (Versions B and A). I used to train and do 1/2 marathons and triathlons, and got very tired of defending my beloved chronic cardio to overweight HIIT purists. No joke. Hard to defend what is obviously ancestral. Our ancestors moved. A lot. They foraged and fought -- they fed their young and fortified their dwellings. They moved consistently often for hours. Genetically some (like apoE4) need to move much more than others perhaps. True also for the Pima Indians who have ancestral-type genetics but live in a discordant, modern, carb-heavy, sedentary ecology. See here, here and here.

New Elite Irish National Rugby Team Player Study:
Exercise and associated dietary extremes impact on gut microbial diversity (free PDF)
Clarke et al. Gut. 2014 Jun 9.

According to the study, “The results provide evidence for a beneficial impact of exercise on gut microbiota diversity but also indicate that the relationship is complex and is related to accompanying dietary extremes.”


Science daily recap: The Irish rugby team has exceptional guts: Exercise and diet impact gut microbial diversity

Editorial by Georgina Hold: The gut microbiota, dietary extremes and exercise

Exercise and higher dietary protein related to better guts and statistically related to diversity (=better gut) and lower inflammatory biomarkers compared with controls. Very well done IMHO, though INFINITE confounders lol.

Many factors raise diversity which the researchers failed to address:
(1) exposure to dirt/soil organisms on the rugby fields (dirt can make you happier)
(2) contact with diverse other players' skin, spit, sweat, whatever is like how dogs and their owners share microbiota
(3) being outdoors and contact with environmental microorganisms (lower disease and atopy)
(4) genetic variants (selective for warrior genes, elite athleticism, super guts, lower inflammation, etc)


Here's a synopsis from the researchers:

What is already known about this subject?
▸ An altered gut microbiota composition has
been associated with a number of diseases and
syndromes, including obesity.
▸ We and others have shown the primacy of diet
in influencing the microbiota in obesity.
▸ Loss of gut microbiota diversity has been linked
to an increasing number of conditions such as
autism, GI diseases and obesity associated
inflammatory characteristics.
▸ Akkermansia muciniphilla abundance has been
shown to inversely correlate with obesity and
associated metabolic disorders.

What are the new findings?
▸ This is the first report that exercise increases
gut microbial diversity in humans.
▸ Protein consumption positively correlates with
microbial diversity (correlation coefficients
0.24–0.43).
▸ The athletes in the low body mass index (BMI)
group had significantly higher proportions of
the genus Akkermansia levels compared with
the high BMI group.


How might it impact on clinical practice in
the foreseeable future?


▸ Our findings indicate that exercise is another
important factor in the relationship between
the microbiota, host immunity and host
metabolism, with diet playing an important
role. Further, intervention-based studies to
tease apart this relationship will be important
and provide further insights into optimal
therapies to influence the gut microbiota and
its relationship with health and disease



New Zealand Rugby Team
Source

Spectacular Abs, Spectacular Gut Microbiota Diversity

The elite athletes had way more butyrate producers (Rumino, Clostridia, etc) and Akkermansia muciniphila compared with both high BMI and low BMI controls. These species found in higher abundance in the healthy athletes are also the same found in our lean ancestral core that I discussed earlier and how to achieve: Sorry. Resistant Starch is Unlikely to Miraculously Cause Weight Loss and Body Fat Loss

A. muciniphila is very unique making up 3-5% of fecal microbiota in healthy folks. IT LOWERS BODY FAT. The mechanisms are unknown but if A. muciniphila are fed to rodents, they lose body fat. If they are fed their favorite foods (oligofructose) then A. muciniphila populations are restored and weight loss in rodent models ensues. It is also associated with elevated endocanabinnoid concentrations and maintains healthy blood glucoses (maybe this is why pot causes lower glucose... thus 'munchies'?).



Unlike Resistant Starch, Oligofructose and Inulin-like Fructans Cause Miraculous Body Fat Loss and Weight Loss

Yes. Many fibers induce fat loss, but resistant starch is not one imho.

Inulin and oligofructose often areHumans and rodent model research.

It works for me. It's half of Version B of my super bionic fiber formula. Inulin and oligos are naturally found abundantly in onions, leeks (French stay skinny on leek soup), asparagus, sunchokes, etc. It's sweet tasting with little energy/calories for us but plentiful for the intestinal flora.

I believe it's body fat reducing characteristics are related to A. muciniphila and many of our co-evolved ancestral core microbiota which have co-adapted to eating the diverse spectrum of plant polysaccharides on Earth that we feed them (oligos, inulin, xylan, arabinoxylan, lignin, arabinogalactan, beta-glucan, hemicelluloses, pectin, glucomannan, etc). They have diversified above and beyond raw resistant starch. You don't need a lot. Oligofructose and inulin-like fructans are the second most abundant 'fiber' on the planet, found in over 36,000 plants in our global ecosystem in roots, tubers, legumes, leaves, grains, agave, cacti, and stems. Tiny amounts go a LOOOOONG way.

In humans, A. muciniphila is 'missing' in the gut fingerprint of obesity, T2 diabetes and IBD, to name just a few post-industrial conditions. When I look at a gut profile, what I see matches the studies; in obese/weight-challenged, A muciniphila is low. In lean, abundant.
"In the article that appeared on 13 May in the journal Proceedings of the National Academy of Sciences, the research team concluded that the bacteria are less frequent in mice with induced obesity and with type 2 (adult-onset) diabetes. Furthermore, administering rather indigestible fibres such as oligofructose, known for its advantageous effect on intestinal biota, resulted in a recovery of the Akkermansia population in mice. The presence of the bacteria strengthens the intestinal barrier and is also inversely correlated with weight increase (fat storage), inflammation reactions in fatty tissues and insulin resistance.

To check that, the researchers administered Akkermansia bacteria to ordinary mice on various diets. With a normal diet, no effect was noticed but in mice that became overweight as a result of a high-fat diet, the Akkermansia bacteria caused a reduction in fat development and associated metabolic defects, without affecting food intake. After the administration of Akkermansia bacteria, there was an increase in endocannabinoid levels, a substance that ensures blood glucose remains at the correct level. In addition, the intestinal barrier function was strengthened. Only intact, living bacteria produced these results; the researchers noticed that bacteria that had been heated beforehand had no effect." Sciencedaily


Back to Healthy, Elite Rugby Players With Spectacular Guts

The athletes were in training. They exercised, built lean muscle mass (biomarker: CK), burned fat, and consumed way more fiber (conventional) 39 g/day v 20-something g/day by controls. They ate vastly higher volumes of food in general (exceeding 4400 kcal/day) because they ate more starches/carbs + vegetables/fruit + MEAT.

They ate way way way more protein including whey protein from powders (sulfur source) than controls  (median 2.4 g/kg v. 1.1-1.6 g/day in controls) and protein intake was found to be directly related to healthier guts/diversity. I think dietary protein is awesome as long as we achieve enough fiber and exercise/oxygenation/lymph-circulation... Dietary protein is aligned to our carnivorous guts and ancestral history. Given however after mass microbial extinctions in our guts that are unparalleled in the history of mammals, we do not digest as well as our ancient predecessors. Suboptimal gut health is marked by poor gastric acid secretion (hence GERD/heartburn!), low elastase and other pancreatic enzyme secretion, loss of gall bladder function/stones, poor fecal pH, lack of gut microbial fermentation and small intestinal permeability/inflammation. We are missing our ancestral core bacteria, yeasts and wild spirochetes that keep us healthy and digestion smooth and unfettered.

Dietary protein consumption also correlated with muscle mass (CK). As you're probably aware muscle is a good biomarker for longevity (sarcopenia, less longevity -- please see Jamie Scott's AHS14 Presentation).

I like how this study by Clarke and his University College Cork colleagues put a framework to muscle, diet, exercise and gut health here. These guys were in intense conditioning for their sport... no junk or 'snacks' compared with controls. Diet was apparently clean and dialed for optimal glycolytics, POWER SPRINTS and chronic cardio. Only water polo players might give them a run for their money lol.
"The athletes are an exceptional group in terms of their dietary intake, fitness/endurance and now we know, in relation to their gut microbiota! This high diversity is particularly linked with exercise and protein consumption and suggests that eating specific proteins and/or exercise can provide a means of increasing microbial diversity in the gut.

This is the first report that exercise increases microbial diversity in humans. While we and others have previously shown that diet influences microbial diversity, we can now report that protein consumption, in particular, positively correlates with microbial diversity." Source


Other related news:
How exercise may affect gut hormones, weight loss

Monday, August 25, 2014

FARMACY: Leras Family Farm in Santa Rosa



Local, Organic, Sustainable Farms like Leras Family Farm

My kids and I had the pleasure to spend a day at the Leras Family Farm in Santa Rosa last Tuesday. We had a total blast! We played with the two baby calves with Zak (intern), fed slop to the Red Waddle pigs, amusingly watched 24 piglets forage and root on their acreage, studied Danielle the intern making cheese, picked basil, berries and grapes, drank their kombucha and chased and played with their beautiful soy-free, free range chickens in two coups.

Thanks for Dave, WAPF chapter leader in Berkeley for helping to set up!

Mike Leras with my d Hannah and I

FARMACY

What's so awesome about the ecology and environment of an organic farm like Michael Leras and his family's (gorgeous wife Jill (former model), 2 sons, doggy Brownie) is not only the inclusive recycling of all the nutrients from produce and leftovers but the completeness of the system: animals + plants. It's a true farmacopeia of happiness nutrients that every brain, gut and body needs.

Michael and his family go to Three Stone Hearth in Berkeley for families to pick up their fresh products like soy-free eggs, pork, grassfed beef, etc every week on Wed night and Saturdays.



Antidepressant Microbes In Soil: How Dirt Makes You Happy
"Soil Microbes and Human Health: Did you know that there’s a natural antidepressant in soil? It’s true. Mycobacterium vaccae is the substance under study and has, indeed, been found to mirror the effect on neurons that drugs like Prozac provide. The bacterium is found in soil and may stimulate serotonin production, which makes you relaxed and happier. Studies were conducted on cancer patients and they reported a better quality of life and less stress.
Serotonin has been linked to such problems as depression, anxiety, obsessive compulsive disorder and bipolar problems. The bacterium appears to be a natural antidepressant in soil and has no adverse health effects. These antidepressant microbes in soil may be as easy to use as just playing in the dirt.
Most avid gardeners will tell you that their landscape is their “happy place” and the actual physical act of gardening is a stress reducer and mood lifter. The fact that there is some science behind it adds additional credibility to these garden addicts’ claims. The presence of a soil bacteria antidepressant is not a surprise to many of us who have experienced the phenomenon ourselves. Backing it up with science is fascinating, but not shocking, to the happy gardener.
Mycrobacterium antidepressant microbes in soil are also being investigated for improving cognitive function, Crohn’s disease and even rheumatoid arthritis."
Read more HERE. Hat tip: Keith Bell.