Wednesday, July 30, 2008

Corona and Lime -- UR Mine

Corona and Lime
By Shwayze
video
Courtesy of Youtube.com


Will miss you... RIP

Adieu Amber Ale... So long, farewell, Hefeweizen! Bye-bye Bud Light...

The last wheat products to go...



My phytoestrogens will have to be sourced elsewhere like from barley-only beer -- GO HOP -- **hip-hop** HURRAY...

See below abstract -- Luv our microscopic friends and fauna that reside in our mile-long bowels! Treat them well...

In my former career as a research associate, I worked on barley and calmodulin (yes a target of Vitamin D -- who knew?). A great deal of my time was spent on northern blots (which takes a certain knack b/c RNA deteriorates easily) and southerns (DNA's durable Thank God). Yes, we were partially funded by the USDA (as well as beer companies.... j/k! maybe ??indirectly??). Had to test theories and research qualitative factors... after work beer with the post-docs and grad students was often a job requirement... no joke *hee*.
    • Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin.
      Possemiers S, et al.
      J Agric Food Chem. 2005 Aug 10;53(16):6281-8.
      Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Gent University-UGent, Coupure 653, Gent, Belgium.
      Hop, an essential ingredient in most beers, contains a number of prenylflavonoids, among which 8-prenylnaringenin (8-PN) would be the most potent phytoestrogen currently known. Although a number of health effects are attributed to these compounds, only a few reports are available about the bioavailability of prenylflavonoids and the transformation potency of the intestinal microbial community. To test these transformations, four fecal samples were incubated with xanthohumol, isoxanthohumol (IX), and 8-PN. Upon incubation with IX, present in strong ales up to 4 mg/L, 36% was converted into 8-PN in one fecal sample and the estrogenic properties of the sample drastically increased. In an experiment with 12 fecal cultures, this conversion was observed in one-third of the samples, indicating the importance of interindividual variability in the intestinal microbial community. Eubacterium limosum was identified to be capable of this conversion (O-demethylation) of IX into 8-PN, and after strain selection, a conversion efficiency of 90% was achieved. Finally, strain supplementation to a nonconverting fecal sample led to rapid and high 8-PN production at only 1% (v/v) addition. Up to now, the concentration of 8-PN in beer was considered too low to affect human health. However, these results show that the activity of the intestinal microbial community could more than 10-fold increase the exposure concentration. Because prenylflavonoids are present in many beers with IX being the major constituent, the results raise the question whether moderate beer consumption might contribute to increased in vivo levels of 8-PN and even influence human health.
      PMID: 16076107


    Stuff from my old lab below -- flora and fauna -- sometimes not much different. Many hormone actions and metabolic rules are conserved across nature.

      • Nitric oxide acts as an antioxidant and delays programmed cell death in barley aleurone layers. Beligni MV, et al. Plant Physiol. 2002 Aug;129(4):1642-50.
      • Hormonally regulated programmed cell death in barley aleurone cells. Bethke PC, et al. Plant Cell. 1999 Jun;11(6):1033-46.

4 comments:

Anonymous said...

G - Did you see this article in today's NY Times about PPAR, exercise and drug therapy?

http://www.nytimes.com/2008/08/01/science/01muscle.html?hp

What do you think?
-Russ

Dr. B G said...

Hi Russ,

What do you think, being the amazing athlete that you are?!

Can you put exercise in a pill?

There is a reason evolution-wise why we deep breathe, isn't there? I know for me, the lower lobes of my lung don't open up until I exercise continously for 1 hour -- then I feel really relaxed, the runner's high kick's in and many other hormones are generated. It is quite the mix of awesome naturally self-made 'drugs'. No adverse effects -- except lookin and feelin HAWT and not bothered! However it is rather annoying to have to replace my ASICS every 300 miles...

Why wouldn't anyone want that?

Some PPAR-delta agonists are so selective (meaning they ignore PPAR alpha and gamma) which can lead to future problems... like cancer for one. Who knows what else when people continue pigging out on carbs/wheat-products and industrial polyunsaturated veggie oils, and continue to be sedentary?

That is a very interesting article! Thank you for bringing it up!

-BG

Anonymous said...

My reaction is that I like to exercise! But then again not everyone does. Nor can everyone do so effectively. Perhaps for those people this could be shortcut. I, however, went out tonight and ran a sprint sequence at the track and felt great afterwards. Nonetheless, the ideas in the article are intriguing, to say the least. I thought you might find them interesting.

Yes, it is good to replace the running shoes every 300 miles or so. I favor the Saucony Grid Hurricane but whatever shoe works for you is the way to go.

-Russ

Dr. B G said...

The researcher states that the second medication Aicar works without exercise but the scientific literature which shows the most benefit is Aicar + exercise.

Trials show over and over that most drugs don't work exceptionally well without exercise. Exercise and lifestyles always trumps a pill by 2-10-fold. Many people will want a 'shortcut' when again none truly really exists...imo... By human nature, people will FLOCK to this drug (thanks again for bringing it up!)

No doubt this drug will work in humans to some degree from what I understand about this pretty spectacular receptor PPAR-delta! And will have wide application -- cancer, diabetes, obesity, hypertension, CAD -- you name it and I foresee that it will be marketed to 'cure' it.

But what works naturally and more effectively is...
--protein consumption (automatically causes thermogenesis)
--carb restriction/IF/ketosis
--weight training
--endurance training
--high intensity training
--EPA+DHA
--vitamin D3
--mental stress reduction

But most non-motivated Americans won't go for that... maybe if they put that in a USDA pyramid? If the US Govt actually paid for social healthcare, they might?
-BG