Friday, October 16, 2009

Body Fat Loss: Saturated Fat Kicks the Cr*pola Out Of Olive Oil

Loren Cordain Is Getting Into Coconut Oil

Yes. It is true.

O F

C O U R S E . . .


From Robb, "Cordain likes coconut oil, just as a mix to a standards paleo approach. " (adrenal post) Robb cracks me up.

Recall Dr. Cordain's recent publication with the history-making conclusion: 'In general, experimental evidence do not support a robust link between SFA [saturated fatty acid] intake and CHD [coronary heart disease] risk.' PDF click HERE Curr Treat Options Cardiovasc Med; 2009;11:289-301. I just had to repeat that. It's like... *haa* the SOUND OF MUSIC... [the hills are alive... *big winky*]




The Thing About Fat...

Let me quote another expert, Jeff Volek (see his testosterone study at end), "The Fate of Fat: You are not what you eat; you are what you do with what you eat. Eat fat with carbs you get fat, but eat fat with low-carbs and you get LEAN — and insulin is the switch that controls the fate of fat.

— Jeff Volek, The New Low-Carb Guru

This is true if you are eating olive oil, monounsaturated fats, omega-3 oil, canola oil, coconut oil or MCT oil. Cut out carbs. Esp GRAINS, LEGUMES and FRUCTOSE. FRUC F*CTOSE, the nastiest carb of them all. (If you are gonna have limited carbs... yams, sweet potatoes, red potatoes, and wild berries (higher in oils, lower in sugar) are slightly more acceptable.).
This holds especially true for those who are insulin resistant (HYPOTHYROID (e.g. FT4 and FT3 s*ck), lacking other major steroid hormones (adrenals, testosterone, estrogen, progesterone, adiponectin, vitamin D, and the previously or currently overweight/obese... like me, I used to be 50 lbs fatter *wink*).




Medium Chain Sat Fats and Coconut Oil

Coconut oil is ~100% saturated fatty acids.

No industrial toxic omega-6. No industrial trans-fats.

There are civilizations which consume high, ULTRA-high saturated fat diets (40-56%) of coconut oil with no elevated associations of cancer, heart disease, dental disease or chronic conditions (Tokelau, Sri Lanka).

Coconut oil and MCT Oil are thermogenic and produce ketones despite consuming carbohydrates.

Coconut oil is predominantly medium-chain triglycerides (only 28-30% long-chain). Coconut oil is 1:1:6 (C8:C10:C12). MCT Oil is ~1:1 (NOW brand) or 2:1 (MCT Gold); no lauric acid, C12.

Butter is ~1:2:2. (70% saturated, 20% monounsaturated)





Medium Chain Sat Fats and Breastmilk

Human breastmilk is 40+% saturated fatty acids and high in cholesterol. The role of medium chain saturated fatty acids in the early survival of babies cannot be overstated. Medium chain sat fats are anti-microbial and anti-fungal and promote ketosis which is anti-inflammatory. Lauric acid (C12) exhibits POTENT PROTECTIVE properties. I discussed earlier here (californication post). Colostrum medium-chain ratios are 1:10:60; HEEEYYYYGE GINORMOUS quantities of protective lauric acid. Mature breastmilk, as well, 1:10:40 (Gibson RA et al Am. J. Clin. Nutr. 34: 252-257, 1981.). Baby infant formulae contain negligible lauric acid (C12), omega-3 fatty acids or cholesterol (Giovanni et al Acta Pæd 83(s402):59 - 62). F*Q. Does that explain anything healthwise? Was not 'in fashion' to breastfeed in the 1970s (at least not in Nebraska). Commercial infant formulae actually contain a lot of TOXIC omega-6 LA (Oveisi et al Acta Medica Iranica, 44(4): 225-229; 2006.) The omega-6 LA is soybean and/or peanut oil (WTF?) (p.97, Natural toxicants in food By David H. Watson).




Ketones

How does Slo-Niacin (vitamin B3) work?

It hits the ketone receptors which is anti-inflammatory and subsequently leads to lower sdLDL, annihilation of the 'death band' LDL-IVb (the most dense and lethal), and raises the HDLs OUT OF THE ROOF.

Again, how do we produce ketones?
--low low low carb diet
--low low carb diet
--low carb diet
--physical low-moderate intensity activity > 1-2 hours (max HR 50-60%)
--fasting > 5-6 hours
--intermittent fasting 12-36 hour fasts (we all do this in the Paleo blogosphere, Crossfit, evolutionary lifestyles)
--starvation
--drink human breastmilk (just kidding)
--eat a lot of medium chain SATURATED fatty acids (coconut oil, coconut butter, MCT oil, coconut milk/meat, grassfed goat cheese/milk, grassfed butter oil (greenpasture.org), grassfed butter/ghee/cream, etc)


Apparently eating saturated fats 12% in the form of MCT Oil can double the body fat loss compared with equal portions of olive oil in near-obese (BMI ~29) men and women on a muffin diet. (Yes, high carb muffin diet.) These studmuffins still somehow lost body fat -- visceral and subcutaneous.

P H A T ! ! !



Saturated Fatty Acids Bind PPAR-Receptors

Saturated fatty acids are hormonal in action. They bind the potent PPAR series of steroidal nuclear hormone receptors (that drugs bind like Actos for diabetes and Tricor for low HDLs, high TGs). Food is our medicine. Recall saturated fats bind PPAR: prior post Lp(a) Dangerous At Any Level. Dietary carbohydates, on the other hand, degrade the PPAR receptors and raise Lp(a), inflammation, insulin and plaque progression.
Remember... medium chain saturated fatty acids are anti-aging (because they bind and activate PPAR and promote anti-inflammatory ketones)... it is a frequent component of the diets of many centenarian and long-living communities (Okinawan, Sardinian, Cretan, Belgium -- from goat milk and dairy products). Check this out again: Kaunitz. Medium chain triglycerides (MCT) in aging and arteriosclerosis. J Environ Pathol Toxicol Oncol. 1986 Mar-Apr;6(3-4):115-21.

In upcoming posts, my buddy NephroPal Dr. T will be reviewing the PPAR receptors. WOOO y-e-a-h !!




MCT Oil Kicks the Cr*pola Out of Olive Oil
St-Onge MP et al conducted a double-blind RCT comparing a low calorie, 'free living', 12% saturated fat/MCT Oil diet (medium-chain triglycerides, 50% of coconut oil) versus 12% olive oil diet for weight loss (Am J Clin Nutr. 2008 Mar;87(3):621-6). Free PDF click HERE. This is the only head-to-head trial I have found comparing MCT Oil and Olive Oil (another one used 24% saturated fat, 40% fat Canadian diet + 3% unesterified plant sterols + flaxseed oil which showed Pattern A 25.85 nm shifting versus 24% Olive Oil Pattern B mean peak LDL 25.45 nm in only 28 days; PDF click HERE, St-Onge MP et al 2003)
The MCT Oil and Olive oil diets were low-fat (naturally HIGH CARB) muffin diets.
The results were surprising.
Body fat recomposition.
Reductions in both subcutaneous fat and visceral fat which is highly associated with PLAQUE and heart disease.

One tablespoon of MCT Oil or coconut oil is ~ 15 grams of pure saturated fat. MCT Oil is liquid and can be heated (like olive oil) to a degree (though I wouldn't heat either). The participants in this study consumed about 1-2 tablespoons daily in a 4-month weight loss program, in the form of a muffin (10 grams) and cooking oil (8 or 14 grams).
DESIGN: Forty-nine overweight men and women, aged 19-50 y, consumed either 18 or 24 g/d (women or men, respectively) of MCT oil or olive oil as part of a weight-loss program for 16 wk. Subjects received weekly group weight-loss counseling. Body weight and waist circumference were measured weekly. Adipose tissue distribution was assessed at baseline and at the endpoint by use of dual-energy X-ray absorptiometry and computed tomography.

DIET INFO:
As part of the weight-loss program, the subjects were counseled to reduce their caloric intakes to 1500 kcal/d forwomen and 1800 kcal/d for men. Within this diet, all subjects received study muffins (either cranberry or blueberry; Krusteaz, Seattle, WA) that contained 10 g of their assigned oil and 8 or 14 g of liquid oil, for women and men, respectively, to incorporate into their foods during cooking. Therefore, all subjects received 12% of theirprescribed weight-loss energy requirements in the form of thestudy oil (18 g for women and 24 g for men). This level of oil was chosen because it was found to produce significant increases in energy expenditure (8). The subjects, along with the dietitian and clinical coordinator, were unaware of the oil each person was consuming. Muffins were given to the clinical coordinator in bags labeled with the subject’s study ID code and A or B to designate group. Oil was provided in opaque plastic containers, which were also labeled with the subject’s study ID code and A or B
.






High Saturated 12% Fat for Weight Loss





High Sat Fat 12% Diet: 1.7 kg (~4 lbs) More Weight Loss After 4 MonthsThe authors showed a significant trend in body fat recomposition with employing MCT Oil as the primary fat in a free-living weight loss program. It is unknown what precisely the carb, protein or total fat intakes were other than ' low calorie'. This is a major limitation of this little trial. On the other hand one of the strengths was the use of technology (DEXA and CT scans) to accurately assess body fat. Few studies examine body fat recomposition with diet.

Results:
(1) both olive and MCT oil produced average 2.4-2.5 cm waist circumference loss (p=0.0001)
(2) MCT oil produced more body fat reduction 1.46% BF decreases v. 0.58% BF (p=0.0037)
(3) MCT oil produced more pronounced weight loss 3.2 kg (7 lbs) v. 1.4 kg (3lbs) (p=0.001)
(4) Visceral fat loss (intraabdom) 6.7-fold more (MCT oil: 8.85 cm2, NS, n=14 heavy drop outs)
(5) Subcutaneous fat loss (abdominal) 2.2-fold more (MCT oil: 24.76 cm2, NS, n=14 only due heavy drop out rate)






Higher Saturated Fat and Higher Fat Intake Associated With Higher Testosterone

See below diagram discussed earlier HERE. Volek JS et al has already showed that higher baseline testosterone has been highly associated with appropriate total fat (30+%) , protein intake (15%), saturated fat and fat composition (low LOW omega-6, saturated to monounsaturated ~50:50) (J Appl Phys 1997).

Higher the testosterone when:
--higher the saturated fat intake
--higher the overall fat intake
--protein not exceeding 15% (when carbs high)
--lower the PUFA/sat fat ratio, e.g. lower the PUFA, higher saturated fat intake
--lower the PUFA (e.g. canola oil, soy, saff, sunflower, peanut)



Grassfed Australian meat is 'balanced' -- whether it is mutton, lamb, beef or veal -- the fatty acid profile is ~50/50 for saturated to monounsaturated fatty acid ratios. Please see Table 4 (at the very end). Click HERE for PDF. Muscle meat is only 5-8% fat whereas 'fat meat' is about 40-60% fat (rest is collagen, water, proteins).

Eat meat. ALL of it. Fat meat and muscle meat.

Don't fear B E I N G A MEATHEAD. Or FATHEAD.




Testosterone: Male Fountain of Youth

We use testostosterone (topical cream and gels) for correcting lipoproteins and regression of plaque. Testosterone is great STUFF. Pound some saturated fats and do resistance training... the best way to naturally produce testosterone. I love Xfit. We do saturated fats + lifting/power exercises = Big 'T'. Testosterone is everywhere... I could lick it off the walls... *haaa*



Next Post:
Body Fat Loss: MCT Oil Kicks the Cr*pola Out Of Canola

52 comments:

David said...

So G, do you think Dr. Eades, in his new book, should have recommended MCT oil instead of DAG oil (ENOVA)??? -Sigh- You know about this, right? Frankly, I was a little shocked that my low-carb hero Dr. Eades would be recommending DAG, which is an artificial, soybean/canola vegetable oil blend. I've seen him defend this, saying that it seems harmless short-term, and it seems to help for weight loss, etc. But it just seems so opposed to the principles of good low-carb/paleo diets. What happened to being cautious of "modern" foods - especially a suspicious hybrid vegetable oil made from soybeans and rapeseed??

I believe that DAG will eventually be found to have problems, just like the other artificial oils that have come before it. It's unnatural to the body. Why would we think this is somehow okay?

I'll stick with MCT/Coconut oil.

Dr. B G said...

Does he advise that ? I know in the shakes he advises coconut milk which can contain a fair amount of saturated fat.

I would have to strongly concur ... (the next post is on rapeseed/canola and soybean blend -- long-chain triglycerides). MCT oil pounds the heck out of soy+canola/rapeseed!

David said...

Here's what he says in one of his comments on his blog:

"You substitute a tablespoon of the DAG for a tablespoon of one of the other oils you might use. If you can’t get the DAG, then just use your regular oil. Of all the components of the program, the DAG is probably the least important and can easily be eliminated. A number of studies have shown, however, that adding just a little DAG can boost weight loss, so we added it in because we used it ourselves because we wanted to do everything we could do in the 6 weeks we had to get ourselves ready for our show."

So it's not a whole lot, and at least he's not emphasizing it strongly, but still. :(

Dr. B G said...

David,

I wonder what the studies have suggested? Eades is very evidence based so that would be interesting... someday I'll get the book. After I finish Brain Trust I guess! And WAP! And GCBC! And the other pile by my bed...

I have tried something called Yes! oil -- that stuff works. I had good healing after a bike accident involving multiple superficial wounds :) All better in 1-2 wks little scarring (which is unusual for me). Carnosine and some other protein supplements were good too (thank you Neo buddy!!)...

I don't think Cordain would advise enova EVAH...! Yes -- I would rather stick with plain omega-3, flaxseed, borage/primrose and coconut oil/MCT and maybe Yes.

-G

steve said...

Dr BG: Coconut oil and MCT OIl are not the same. MCT Oil is fractionated from Coconut Oil to create a medium chain fatty acid with a a chain of 6, 8, or 10 carbon atoms. It is not a long chain fatty acid like Coconut Oil and burns up quickly like a carbohydrate and has the benefits of Coconut without the sat fat. Interesting that the study on weight losss uses MCT and not Coconut Oil.The Gov requires all MCT's to be labeled as sat fat, which they are not. Brain Trust recommends MCT Gold; another good one is CapTri by Parillo-at Parillo.com

epistemocrat said...

Awesome rule to live by, Dr. B G:

"Pound some saturated fats and do resistance training... the best way to naturally produce testosterone."

I'm on that plan.

It works quite well.

And I rub some coconut oil on my face ...

Best,

Brent

David said...

Dr. Eades' attention to detail and his passion for the "facts" is a big reason I admire him so much. When he says something, I listen.

I've read over several of the abstracts for the DAG oil studies. Intriguing, to be sure, but not enough info in the abstracts to really see what all is going on. The common theme is that DAG greatly increases fat oxidation compared to other oils.

I guess a thing isn't necessarily bad just because it's a new creation (like the DAG oil), but...when has this never been the case? People have "tweaked" all kinds of foods, thinking it made for better, healthier food, only to have it eventually backfire every time. Seems like history would teach us something.

Perhaps human ingenuity will eventually come up with something (and maybe this is it!) that is truly helpful/healthful at best, and benign at worst. Yes, one can hope -- but with a healthy dose of skepticism in the meantime!

David

Dr. B G said...

Brent,

Coconut oil is a natural UV block and when I occ get too much sun, it reduces redness/itchiness somehow immediately.

Yup, it's awesome stuff!





Steve,

OMG. I am so impressed with your growing knowledge!! You ROCK dude. Awesome issues you bring up. Coconut oil is triglycerides -- this is the 'storage' form (temporary) not only in plants, animals but also for humans. C12 is also medium chain (known as lauric acid -- I've discussed on the blog -- it's found in healing antioxidant herbs like bay leaves).

Coconut oil is mostly medium chain saturated fatty acids in the form of 'triglycerides'. The coconut oil TGs are saturated... inclu MCTs. I believe the labelling is correct.

MCTs are saturated in both the nutritional as well as biochemical sense.

Maybe this might clarify for you (look at the 3 chains attached to the glycerol backbone):
http://www.scientificpsychic.com/fitness/fattyacids1.html


The long chains are limited < 28-30% of total fats. You are right the long chain have the potential to be stored on the behind. But as we discussed earlier -- palmitic acid is the preferred fatty acid to float around between meals or when we are fasting. This is the normal 'state' for most mammals. Neolithically on the other hand, S.A.D. humans seem to eat ALL THE D*MN TIME. It is not nutritionally necessary. Eating every 2-3 hrs goes against the grain of our genetics. Grows plaque and fat too.

There are ancient signals and pathways for palmitic acid (which I am still trying to fully understand). Ketones too. Ketones are necessary for life. And recovery. Remember babies survive on ketones and colostrum the first 14 days of life. Why? Because they were mentally and physically traumatized the HECK by emerging through the hole the size of a toilet roll.

Other benefits of MCT v. LCT is that MCT requires no pancreatic lipase. Preemies,chronically inflamed inviduals and a lot of TYP members and unfortunately do not have lipase due to underdevelopment (preemies) or disease calcification/ destruction, respectively. Pure MCTs obviously would work better. The LCTs in coconut oil require some gallbladder and pancreatic enzymes for emulsification and absorption. (same goes for impaired vitamin D and n-3 fish oil absorption. need enzymes!)

(MCT oil is semi refined as you said -- that is the only thing I don't like about it and why I would not likely subject it to oxidation via cooking heat or baking... though i made some YUMMMY high carb indulgent gluten-free brownies w/it)


From wiki:
Fatty Acid Saturation Carbons Percent:
SHORT
Caproic Saturated 6 0.5
Caprylic Saturated 8 7.8
Capric Saturated 10 6.7
Lauric Saturated 12 47.5

LONG
Myristic Saturated 14 18.1
Palmitic Saturated 16 8.8
Stearic Saturated 18 2.6

OTHERS
Arachidic Saturated 20 0.1
Oleic Monounsaturated 18 6.2
Linoleic Polyunsaturated 18 1.6

A patient of mine tried both MCT Gold (as you mentioned per Dr. McCleary) and NOW MCT Oil. He said the MCT Gold tasted wretched. NOW brand MCT is tasteless to both me and him.

Please let me know your experiences later! Wanna know facts -- BF% loss, body recomp and how many times you get hit on because you look paleo-hot.

-G

Dr. B G said...

I understand your hesitation! Reminds me of Olestra (anal-leakage side effects).

Fake fats aren't good.

David said...

Olestra! Haha, it's funny you mention that, because I was just reading an old 2007 post the other day by none other than Dr. Eades on that subject. He was saying that it may actually have a good, short term function as a POP detox agent. It was interesting. Here's the post if you wanna take a look: http://www.proteinpower.com/drmike/weight-loss/a-legitimate-use-for-orlistat/

David

Dr. B G said...

David,

Gosh. Your memory is SCARY!

I remember that post too now that you bring it up! Perhaps Olestra disrupts the enterohepatic re-circulation (recylcing) of fat-soluble toxins and endocrine disruptors stuck in the system??

THANK YOU for all your thoughts!

-G

Kennedy said...

Regarding your reply to a comment, I thought Coconut Oil had twice as many calories as MCT Oil?

Great posts, it sure makes me feel manly seeing Diagrams proving the likelihood of my having high levels of Testosterone from all the meat and butter I seem to eat!

Enjoying the blog, your energy and enthusiasm for this subject is tremendous!

Adam Wilk said...

Dr BG,
I'm very, very excited after reading this post--I've just received my HUGE jar of coconut oil and I've been enjoying it in my morning coffee--what a delicious way to start the day!

So once again thank you, but I have another off-topic question, but I'm hoping my father isn't the only one in this boat, either.

Terrified of saturated fats, (I blame Ancel for this...) he eats mostly salads (I'm trying to get him off the PUFA-laced bleu cheeses and other assorted monsters) and lots and lots of fish. I even have him (in your own words) "pounding" Carlson omega-3 fish oils and using butter from time to time to enjoy his eggs. (that was a struggle)
My father is a young man, 63, but he did have his 2nd CABG 2 years ago, so now I'm determined to 'get this right' as he ages.
(Yes, there's a question in here, please forgive me for my long-winded-ness)
Recently his cholesterol came back at approx 300, HDL 59, but LDL 181.
Shit. He feels great, has been exercising religiously, and is trying hard to lose excess weight. His MD wants him back on lovastatin, high-dose, due to his bloody past. Diabetic, too, but HbA1c is at 5.2, not bad for an insulin dependent.
My question to you--despite what I've read on 'WebMD' and 'MayoClinic' sites, I'm beginning to wonder if there's any relationship between his high cholesterol and lack of a gallbladder? (removed over 10 years ago) His own MD told him not to worry about it, but I'm concerned here--here I am, telling him not to worry about saturated fats or even essential fatty fish oils, but he's lacking the concentrated bile that's stored in the gallbladder, not the stuff that gets shunted straight from the liver.
In your experience, in the TYP program, are patients who've had their gallbladders removed treated differently? Is this something I can correct by getting him to take bile salts? Despite what the online medical sites or even his MD say, I'm convinced (after reading your works, especially) that EVERYTHING is connected.
Thanks!
Adam

Dr. B G said...

Kennedy,

You are M A N L Y . *haa* Go Paleo Power!! Hey you have a great blog! My next frontier is neurobio...




Adam,

At TYP at this time, no, the absence or dysfunction of gallbladders is not addressed. Neither is elevated ALT or AST > 12 which to me is a strong indicator of insulin resistance and NASH.

Does your dad have a persistently low vitamin D serum level despite MEGA huge doses like > 10,000 IU daily? If so, then he is probably not absorbing well any of the fat-soluble supplements that are integral to the TYP regression program -- fish oil, flaxseed oil, CoQ10 (unless sublingual formula), vitamins ADEK1 K2, krill oil, carotenoids, tocopherol/tocotrienols. Therapeutic Sat fats! Well -- he's avoiding it sounds like anyway.

Has your dad and his physician considered the high value of starting some digestive enzymes? My patients have tried a variety of brands and they all work. My personal fave is SUPER ENZYMES by the Now brand. Within 24-72 hrs bloating, gas and heartburn typically disappear.

Good luck and let me know how it goes!

-G

Aaron said...

I second the fact that MCT oil might work different in the body than coconut oil.

Also, processed MCT oil might be lower in salicylates and therefore more appropriate for sensitive individuals.

When we gave up multiple stomachs for a larger brain -- we gave up the tons of bacteria that would have changed plant material into wonderful SCFAs for energy. MCTs might offer a similar energy source.

nocarb said...

I've been on a diet that replaces all my LCTs with MCTs, and the rest is protein. It's a bit difficult to do since a diet of 40%+ MCTs is hard on the digestive system.

Dr B G, I've been working on a Blogger gadget that takes all of your PubMed, ajcn, biomedcentral, etc links and organizes them into your sidebar. You can search for it in Blogger gadgets as "pubmed citations"; an example is here

Kennedy said...

Hey thanks, I like to think I am!

You totally should, you could do some damage!

Cheers

Dr. B G said...

Hey MC/nocarb!

Thanks for your help!! That tool looks COOOOOOL. I will ck it out soon and probably add... I need help organizing the citations b/c I can't find anything either :) *ahaa*

Like you I do notice insulin changes with really high fat intake -- is it the PUFAs? Long chain n-6 that I might have become SUPERSENSITIVE TO are a factor??? It seems like after any handful of TJ's lemongrass/ chili rice bran roasted cashews, I gain like a pound of subcutaneous FAT. Annoying.

Your blog is very cool too!

-G

Dr. B G said...

Aaron,

*haa* Welcome. I like your comments a lot.

I've wondered about salicylates. A lot of vegetarians (e.g.India) consume them in diet (coconut oil, olive oil (? or chopra?), SPICES, curry, tumeric, fenugreek, etc).

So in children and those with metabolic fatty acid oxidation disorders (in ability to process long-chain fatty acids), Reye's syndrome can occur after a viral illness recovery (like flu, swine flu or chicken pox) when combined with salicylates like 'baby aspirin'.

Evolution or in utero metabolic effects (epigenetics? glutathione shifts??) have somehow 'selected' those who are HIGHLY salicylate sensitive and those who are not.

Salicylates also block COX which can lead to impaired stress responses due to changes in arachidonic and the subsequent prostaglandin cascades.

This is a big problem as you pointed out for some people -- yet MCTs are essential fatty acids (which are best consumed -- intesting as you sort of mentioned -- our bacteria don't chain lengthen enough to provide for us in our colon /gut). The gut makes butyric but again limited.

-G

homertobias said...

BG
Check out the heart.org this morning. Dr Boaz Rosen's article on CAC scoring and CAD, position of calcium vs position of stenosis, etc. MESA trial. Alot of comments by Harvey Hecht. Despite its deceptive title, I think it definitely is a victory for preventive CAC screening with MDCT. Don't have time this am to check it out in depth.

Aaron said...

Hey -- I know this is off topic, but I see you follow Canibais e Reis. Is there an easy way to do english translation for the site?

All kinds of goodies there!!

KENNY10021 said...

I can't thank you enough for your blog. I have learned so much and have developed a passion for health because of you.

In your latest post you talk about MCT and coconut oil at length. Awesome post. You also mention not wanting to cook with MCT oil.

Well the obvious question, since it is such a topic in debate on TYP and other sites is, "what oil does Dr B G cook in when sauteing mushrooms or the sort?

I gotta know....

Thnaks

shel said...

fat is gold. within my lair, surrounded by rendered tallow, olive oil, red palm oil, lard, fish oil and coconut oil, i am a King! and i am rich. (heh)

KENNY10021 said...

"How does Slo-Niacin (our favorite drug at TrackYourPlaque for regression) work?

It hits the ketone receptors which is anti-inflammatory and subsequently leads to lower sdLDL, annihilation of the 'death band' LDL-IVb (the most dense and lethal), and raises the HDLs OUT OF THE ROOF."

I have always wondered ..... with the success of Slo-Niacin, why not have everyone take it no matter what? Does it do any harm? Fight inflammation, small ldl and HDL....I want my HDL's Out OF THE ROOF! Shouldn't everyone take it like Vitamin D????

Dr. B G said...

Kenny!

(Are you Mr.Oursler Jr?) Isn't that great about TrackYourPlaque? Careful, passion is sometimes misinterpreted as 'crazy'! Of course honestly, I think it is quite crazy for people to continue eating toxins, poisons and living life-span shortening lifestyles.

Right now we cook with ghee (Puritan Farms) and coconut oil. I admit we use a refined coconut oil... ? Is it semi-virgin? is there such a thing? The strong scent is gone and a little more acceptable. I will probably find a source of pastured lard though and use that. Jpatti mentioned leaf lard and that sounds more aligned to what my primal Asian ancestors probably used.

Regarding the Slo-niacin, I do believe the great majority of members take it (but I haven't analyzed any vault data b/c I am so pathetically LOW TECH). The problem is that people take high dose statins. What is considered 'high dose'....??

Well.

Anything where the large LDL fail to appear. And that unfortunately is about 100% of the statinators, esp the more vocal ones (if you notice reports of solid Pattern BBBBAD 50-100% small dense LDL are not uncommon among them). Dr. Davis and I have moved away from frank overstatination if you have been paying close attention to our discussions and our blogs. Some members apparently have not received the '411' sadly.

Statins halt success. That is why heart attacks and strokes continue to occur despite their fairly widespread use globally. They fail to allow conversion to the all important Pattern A and Lipitor is the worse -- it prevents HDL2b from reaching potentially higher levels. Crestor is terrible in my book because it has been highly implicated in kidney disease and inciting clinical diabetes (pancreatic failure). Of course there are many other problems as well (they cause low level muscle and mitochondrial deterioration, inflammation, oxLDL and cancer). Zetia is equally U-S-E-L-E-S-S for regression as well.

Everyone who cannot follow an ancestral, primal, low carb mod-high fat Paleo lifestyle should highly consider the extremely high value of appropriate doses of Slo-niacin for CAD primary and secondary prevention, as delineated in all the niacin trials (dose: 2-4 grams daily).

Side effects? Yeah there are some. The great majority appear to actually tolerate well when the intermediate acting formulations are used (niaspan or slo-niacin).

If post-MI men and women in the Dr.BG Brown MD's HATS trial can do niacin (and LOW LOW ultra LOW dose statin), then most everyone can. These people still had regression despite a cr*ppy high carb AHA low fat idiot diet. Most were also probably semi-diabetic AND hypothyroid AND vitamin D deficient. Our subpop at TYP is not.


Thank you for your kind words!! I love your PASSION!!!

-G

steve said...

so what is your recommendation with regard to coconut oil or MCT oil? Are you suggesting this replace some olive oil on a daily basis?

Dr. B G said...

Hey Steve,

In general, I think getting carbs low (as it sounds you are doing a wonderful job) and adjunctly having a minimum of saturated fats to total 14-25+% daily is ideal for maximum longevity and vitality. As you are aware, more is fine (as long as one is not salicylate allergic, have steatorrhea (oily stools) or seriously lack digestive enzymes or a gallbladder (then supplemental enzymes and probiotics are helpful). A higher fat diet requires some emulsification, healthy gut and pancreatic enzymes and GB bile acids.

Otherwise, higher is fine. The Tokelau consume ~40-55% coconut oil (no n-6 or gluten/wheat/grains but I'm not certain about rice). Total fats per TYP 40% (or more) and half should be saturated in my opinion at this time. N-6 Polyunsats should be minimal < 2-4% daily.

If you read the dosing for MCT oil -- usually it is weight based 1-3 Tbs daily.

Current recommendations for sat are 8% (per the idiot Walter Willet and the AHA). This is killing people and horribly ineffective and pathetically insufficient and incombatible with increasing lifespan. Anything greater than 8% is better than NOTHING. Yes -- consideration for replacing some of the olive oil is prudent. I've not read any good studies where olive oil raises HDL2b. HDL2b is required for cholesterol efflux and reverse transport to get the cr*p out of plaque. Large LDL are nec to bring the antioxidants and further remove the cr*p in plaque. Again, have not seen any good articles for olive oil shifting to pattern A. That would be highly odd without considering carbs and saturated fats. I've seen 1 or 2 trials, but I am suspicious of the authors.
-G

Dr. B G said...

Hey Homertobias,

Thanks!! I am looking forward to catching up on Hecht's comments.



Aaron,

http://www.canibaisereis.com/

O Primitivo's site is truly a GEM!!! You are totally right on! I don't think there is an English subtitled version that I can find. Just grateful that the links are in English!!



Kenny,

The MCT oil smoking point is low and the manufacturers report low temp baking is fine but I wouldn't do it due to oxidation products.

I haven't tried yet -- but MCT oil seems great to use as a salad dressing or anything room temp.

-G

homertobias said...

BG,
Thanks for all your info. Statins, of course ARE over perscribed but do happen to save a few lives. IF, after all other measures have been maximized, someone still is not at goal and has considerable CV disease risk, what statin do you and Dr. Davis recommend? What starting dose? Lipitor and Crestor have the longest half lives and theoretically could be dosed every other day to biweekly (Lipitor) or up to weekly (Crestor). I did not know the HDL 2B effect of lipitor. (Reference please) Thanks

Dr. B G said...

Homertobias,

Thanks for your comments! I have a LONG *SS answer for you...

In all honesty, I cannot make any sort of recommendations for statins at all whatsoever. At all. You are not a member of TYP r u? Regression is near impossible unless a member has a STATINLESS program or has DRAMATICALLY CUT BACK their stupid-statin-dose to low low LOW dose like 'licking the tablet' doses.

Why? Coz statins S*CK.

Statins raise vitamin D concentrations -- crestor raises vitamin D more than lipitor. Get vitamin D to 25OHD 60-80 ng/ml and one would be better off without a doubt. The more complicated the lipoprotein pict, the LESS I believe someone 'needs' a statin. That is ridiculous. They need to figure out the root cause of the lipoprotein issues (carbs? sat fat defic?

Vitamin D and diet trumps statins: No statin-related cancer risks! No nerve and brain damage! No mitochondrial dysfunction! No risks of rhabdomyolysis! No risks of autoimmune disease! No oxLDL! No risk of raising Lp(a)!

Why not optimize the n6:n3 ratio to 1.5 which is MORE effective at 'saving lives', shifting to pattern A, regressing plaque (via multiple mechanisms), organ protection and all-cause mortality (JELIS, GISSI, Lyon Heart)?




In men who carry abdom obesity, fish oil trumps atorvastatin on apoA1 and raising HDL2 (Barrett P 2006):
http://www.ajcn.org/cgi/content/full/84/1/37

Why? Coz statins S*CK.

Atorvastatin lowers apoA1 (which translates to lower HDL2; the authors should've ck'ed the actual instead precursors)

(a) Asztalos B 2007:
http://www.ncbi.nlm.nih.gov/pubmed/17317371

(b) Wierzbicki 1999:
http://qjmed.oxfordjournals.org/cgi/reprint/92/7/387
--atorvastatin raised fibrinogen (at all doses 10-80mg)
--atorvastatin no effect on apoA1
--atorvastatin lowered HDL 11%

(c) Pears and Ollson dose-finding in 8wks poster presented at DALM int'l symposium 2001:
--atorvastatin lowered apoA1
--atorvastatin lowered HDL

Why? Coz statins S*CK.



Rosuva, atorva and Vytorin (?!?) may marginally raise HDL2 (by increasing vitamin D concentrations) but at what cost?? Statins ALL raise Lp(a) by A LOT, toxic sticky proatherogenic Lp(a)

(1)COMPLELL trial:
http://www.ncbi.nlm.nih.gov/pubmed/17239888

Ck out Table 4: 7% and 18%, Vytorin and Rosuvastatin, respectively in men and women with CHD risk factors

(2) Romero et al 2000 in patients with high sdLDL (renal), atorvastatin raised Lp(a) 15% (see Table 2 after 3mos) and HDL reduced.
http://ndt.oxfordjournals.org/cgi/content/full/15/9/1446

Why? coz...


Wallace JM 2005 showed that PPAR agonists (which we know include saturated fats--short/ med/ long chain, cholesterol/egg yolks, omega-3, low carb, exercise, body fat loss, visceral fat loss, etc) BLOW OUT and increase HDL-2b and apoA1:
http://www.jlr.org/cgi/content/full/46/5/1009
(see Table 3 -- why fenofibrate S*CKS incr dense HDL3, NOT HDL2b)


Food, diet, fasting/feasting, movement, lifestyles. These are the best imho... Minimizing toxins (n-6 veg oils incl canola oil, excessive olive oil, heavy metals, mental stress, physical stress, excessive dietary carbs/fructose, wheat/gluten, low-fat-diets, etc).

Jimmy Moore NEVER took a statin and for good reasons. It is highly implicated in heart failure which is what his dear older brother succumbed to last year. Statins deplete out vital antioxidants includine Coenzyme Q10, which is nec for life.

-G

homertobias said...

Hi BG

I don't frequent typ, costs money, I myself have a "0" ca score on MDCT, and my patients are female mostly under 65. (Average Ca score for 50 yo female is "O", for a 55 y/o female is "0", for a 60 y/o female is "0") So if I send my patients for a scan because their lipids are aweful they usually spend $ then get a "0" score and come back 6 months later having gained 5 pounds. (Groan)
TYP is a nice forum. But it is, in my opinion, used primarily by people who have positive CA scores, most of whom have already had an event or at least have documented CAD.
If I were them and I did my best at diet,supplement,exercise, and did not achieve goal, I WOULD DEFINATELY TAKE A STATIN. The problem is that it is much easier to be a couch potato, eat wheat and potatos, remain overweight, and take a statin than diet and exercise properly. You know that.

All said, I beg to differ. I don't think statins s*ck. They are just second or third line theraphy for those people at high risk who really need them.

Your references unfortunately don't seem to say exactly what you say they do.

Your Asztalos reference basically states that crestor has a more favorable effect on apo a 1 (HDL2B) than lipitor does.

Your COMPLELL data shows a decrease in lp(a) on combination crestor/niacin. (Probably niacin mediated)(I wouldn't touch Zetia and discount zetia combined with statin data)

Your Wallace data on fenofibrate is based on 29 total monkeys. Fenofibrate did increase small dense HDL MORE than it increased large fluffy HDL, but it increased BOTH SIGNIFICANTLY. Given fenofibrate's strong data on saving human lives I think it is a useful adjunct to those whose HDL remains low despite adequate Vitamin D(60), 4 g epa/dha fish oil,high dose Niacin, exercise and weight loss.
I don't have full article texts of some of your references.
My bottom line, I need to get off the internet and get some exercise.
Don't get me wrong BG, I love your enthusiasm and your expertise.

Dr. B G said...

Hey Homertobias,

I like your thoughts -- thanks for going thru the literature -- it was not easy to pull all of them to one spot. You are right -- the studies S*CK *haa* Stephan's and Peter's reviews on statin trials are FAR BETTER. Some statins do come out lookin slightly better than the neighboring one! I wonder WHY?? When all else fails... what should one do right? I do hear ya! Many phsyicians are stuck in the same unenviable position as you...

There is one study I haven't discussed ironically called the Regression trial -- where TGs < 150 and pravastatin showed increased mortality...

If we could do a study at TYP -- it might show definitely that high dose statins don't work with Pattern B and TGs < 150 which is a great majority of compliant members, from what I singly observe. Progression definitely continues with Pattern B (or Pattern A + 'death band' LDL IVb). They are on TYP and have a great program given the role of niacin, fish oil, good anti-inflamatory diet (though low sat fat in many cases), statins, and antioxidants incl vit D. I don't believe in treating a number. I always want to ask -- why is that dense LDL still persisting despite that statin (usually its carbs and low fat)? Why is the HDL2 so lame despite that statin (usually not enough sat fats!!)? Why is the CRP still high despite that statin (chronic inflammation -- leaky gut, hormone imbalances are the frequent causes)?

I am not that clever or smart. Actually I defer to a lot of other physician experts who fail also to see the value in statins, and would hesitate to ever prescribe them. Maybe the studies belie what many experts concede publicly (Dr. Mary and Mike Eades, Dr. Hyman (I heard him speak), Dr. T... many others!)...

We know from the diabetes prevention trials and other prevention trials (GISSI Lyon heart etc) that diet and exercise are always far superior. What else have we learned lately? With the ACCORD and other recent trials, 'overtreatment' harms people -- lowering the A1c < 7% with medications lead to worsening of CAD events. Umm... that reminds me of...

I know you don't agree or see what I have seen but what I notices is that more and more evidence is in fact trickling out that when we try to 'treat' a number instead of the 'root cause' there are failures on multiple levels. These studies focused on the HgbA1C just as the statin studies focus on the LDL.

You know how we equate DM = CAD? I believe in reality it goes vice versa as well. CAD is basically altered insulin, inflammation, and glycemic control. And.. therefore... statins tend to fail on several levels b/c statins really do nothing for insulin or glycemic control. Yes -- they may lower CRP and blah blah blah -- again many of our members hit high dose statins and their CRP is still persistently high. Why? Again, the root cause has not been identified and that statin aint gonna save lives (and may trigger cancer combined with those unresolved inflammatory triggers).

People on the TYP forum have tried 'everything' and they are the best example that statins don't work, in my strong personal opinion. If they did TYP wouldn't exist. Again, the only ones in this modern day that achieve regression on EBCT that I've witnessed are those who are in fact not on a statin or taking so little a dose it is barely doing anything or causing any harm. I am not totally against statins -- and I still use them like you do. The worst progression that I have viewed on TYP are those on Crestor esp the higher doses (many are Lp(a) > 5 also). Why? I have no idea... (well sort of). Go back to the human studies I posted. I agree -- feno has better data than statins (and that aint saying MUCH! b/c I think feno data sucks compared to DAIS or VA-HIT with gemfibro) however fenofibrate also raises the HDL3 preferentially over HDL2 in humans but I just couldn't locate the data. Sorry again for the length. I appreciate your reply! You are busy -- BUSY working out right? -- strong work!

-G

Dr. B G said...

Homertobias,

BTW, you will have to speak to Dr. Davis yourself regarding which specific situations he finds statins mandatory. Have you noticed his new blog intro is "Plaque is the stuff of coronary heart disease. It is CONTROLLABLE, it is STOPPABLE, it is REVERSIBLE. But you must be equipped with the right information on diet, nutritional supplements, and hopefully the avoidance of m e d i c a t i o n . "

As you know, my anti-statin views are NOT the views of TYP, Dr. Davis, Dawn RN or Chris/ Hearthawk... as are any of my views! :) Most of my anti-statin blogs are for Chris in fact if truth beknownst. Studies show that statins block nerve healing and trigger autoimmunity too which are all things that would likely be prudent to minimize on a CAD regression program, don't you think? Anyway, my views may appear strong b/c I am hoping for a 'trickle' up effect for Chris *haa* one of the founders at TYP that I'd like to see stay alive more than anyone else for all the wonderful things he does to support me (like setting this blog up) and behind the scenes at TYP!!!

One must do their own n=1 self-experiment, serially track symptoms, NMR and the coronary calcification scores.

With niacin -- some people report temporal arteritis, high bili, high homocysteine, high glucoses, gout, etc.

Olive oil -- I've heard of 2 reports of angina. One report of being allergic (which may have contributed to a 4-digit score and perhaps even increased risk of clotting DVT).

Thyroid or T4 -- Several reports of increased PACs, PVCs and afib (1?)

Iodine -- Several reports ditto

Ultra high dose fish oil for inflamed individuals -- I guess Dr. D on his blog reported an increase in LDL or dense in one member. Umm well I can think of a million other confounding reasons for dense LDL increase. I believe this member also reported a normal CRP for the first time in his life. Could that be fish oil??

Vitamin D3 -- 1-2 members report that they suspect their increase in annual heart scan are secondary to vitamin D (which is untested, based on speculative use at TYP). Well um again I am personally highly doubtful IMHO due to a million other confounding variables again that have not been ruled out.

homertobias said...

Hi BG

Personally I love your style and your enthusiasm. YOU ARE VERY BRIGHT and you have taught me alot.

Progression on a MDCT is not a heart attack. It certainly statistically is not a good thing but it is a measure of architecture only. Just like some of my 55 yo females get a O calcium score and head to Starbucks instead of the gym, I could see a scared 60 y/o man with an initial Calcium score of say 250 do his best, really his best for 4 years only to panic at a score of 485. Panic,stress,worry and depression also dramatically increase CV events. I gotta look at how the result will affect the individual.

Dr. B G said...

Hey Homertobias,

Thank you for the kind words!

I concur with you but I have no evidence about the MDCT progression. I do know that NO ONE in Dr. Davis practice or Dr. Blanchett in Colorado literally have almost near-zero events when the score is < 10%, both have said (Blanchett at theheart.org and to members at TYP).

If I could look at an angiogram, as long as the plaque grows echogenically (not echolucently) I could conclude that the plaque is stable and therefore unlikely to rupture. Oxidative stress however from the factors that you listed, on the other hand, would likely grow the plaque echolucently ('soft') and thus possibly be unstable. There is no way to differentiate on MDCT I don't think. Stephan and Peter have discussed several H-G tribes who have plaque but near 'zero' coronary events or strokes (or cancer). I suspect they grow stable plaque or have seasons of massive regression. These tribes like the Masai consume high amounts of
--omega-3 (anti-inflammatory)
--saturated fats (eg, statin effect *haaa*)
--MCTs (goat A2 milk/ meat/ blood) which promote serum ketones (eg niacin-effect)

I think that it should be reassuring to anyone with coronary calcifications that are increasing that the chance for an event depends on how much antioxidants one is taking to stabilize the growing plaque (omega-3, carotenoids, vit E, ubiquinones, etc). I like the Lyon Heart trial -- mild improvement in n-6:n-3 dramatically reduced all-cause and cardiac mortality compared to placebo (e.g. statins) by 71%. Antioxidants make a big difference! This group was VERY sick -- overweight, low HDLs and all post-coronary or stroke events. Just like the HATS trial (NEJM 2001) as well -- niacin is a MAJOR antioxidant and involved in phase II mitochondrial P450 and of course energy NADH etc -- niacin raises hGH, adiponectin, lowers BPs eventually and was shown to prevent all-cause mortality as well in nearly ALL the trials hands down. I've had tremendous compliance -- nearly 95% so thank God for niacin (and omega-3). With TYP and my personal 'extras' I have seen all kinds of PVD reversal, HTN reversal, CHF reversal and stable angina reversal within months. In addition to of course Dm2, migraine, fibromyalgia and ED reversal... the list just goes on and on. I do have to say that the stand-alone Dr. Davis' TYP program which of course I LOVE LOVE LOVE (low sat fat, oat bran, no wheat, omega-3 niacin statin) is not enough for most ill individuals to induce disease reversal. It stabilizes plaque successfully but I don't see it reversing in many cases in my patients (and some members on the forum who appear to struggle). I don't know why. Maybe because Lp(a) is an underestimated culprit and the only effective control is low low carb, high saturated fatty acids and ketones?? It turns out that Lp(a) is HIGHLY clinically associated with the DM2 condition I read in one article. I suspect Lp(a) is also prevalent in hypothyroidism (autoimmune thyroiditis) and Met Syn (both are 100% prevalent and underdiagnosed in CAD patients).

-G

KENNY10021 said...

I hate to jump into the middle of such a good thread but.....

This is "the Mr. Oursler Jr". from TYP......and I still love your crazy passion :)))

Let me refocus my question regarding Slo-Niacin as follows.....

"Everyone who cannot follow an ancestral, primal, low carb mod-high fat Paleo lifestyle should highly consider the extremely high value of appropriate doses of Slo-niacin for CAD primary and secondary prevention, as delineated in all the niacin trials (dose: 2-4 grams daily)."

What about people like me who do follow this type of diet and have a calcium score of zero at age 45? My cholesterol is high according to national standards but I am not worried about that. What about someone of normal weight and all health markers in relatively good places? Should I consider Slo-Niacin too? With all the positives, why not? Hdl's through the roof, etc.!!!!

MCT said...

I would also add, that MCTs go above and beyond most LCTs in potentiating ketosis (see this).

MCTs seem to consistently defeat LCTs in weight gain in every study I've seen.
see:

this
this
this
this
this
for just a few.

At the same time, however, MCTs are insulinogenic.
In my experience it's hard to tolerate MCTs past around 40% of total energy intake.

I went to a physician today for a physical and to get blood work done. She hasn't heard of Dr. Eades, told me coconut oil is poison, and expects my triglyceride results to be horrendous.

homertobias said...

BG

That last post of yours will take awhile to digest. So much information! BTW echogenic/echolucent are usually ultrasound not angiogram terms.
I wish that I could get a fraction of the compliance with niacin that you seem to get. The ability to motivate others into a more healthful path is a precious gift.
Niacin is one of my favorites as is D and fish oil.
Another is metformin. WHERE ARE THE FASTING INSULIN LEVELS on TYP?
The Hgb AIC's? NMR lipoprofile is coming out with a new format emphasizing insulin sensitivity. By the time an individual has impaired fasting glucose or impaired glucose tolerance (prediabetic state) they have lost 80% of their beta cell function. (Ralph De Fronzo).
Chaio for now.

Dr. B G said...

MCT,

O M G those are great links!! I can't wait to read them. I've wondered about the ?? potential insulinogenic effects of MCTs -- some trials don't report that like the next blog post I will eventually get to. I guess others do -- do you know why? Carbs? Grains? omega-6 PUFAs? I wonder if it is post-prandial? Or just pre-meal/fasting? Just returned from a camping trip so I have some catching up...




Kenny,

For many mitochondria and metabolic pathways, B3 (niacin) is necessary. Just as necessary as B6, Vitamin C, amino acids, Zinc, Selenium and Magnesium. So... with that said yes I believe some amount of niacin would not be harmful but again depending on family risk factors and what the diet is. I try to get most of my niacin from organ meats!! If I feel a cold coming on I pound some niacin (which also keeps the chills away *big smile* and gives me a glow like I am a red-cheeked Asian GRRRRRLL who fails to exhibit the alcohol dehydrogenase enzyme). BTW great heartscan report!





Homertobias,

Thank you for your great thoughts and sharing your pearls!! WOW that insulin sensitivity test might extremely useful. Basically I look at someone's 'belly'. They could be thin or fat -- but the visceral tummy fat is usually evident which correlates well to the lack of IS.

Normal insulin is < 4.0. Normal hgba1c is < 4.0.

I wrote this a zillion years ago:
http://drbganimalpharm.blogspot.com/2008/04/passion-for-eradication-part-deux.html

Still I don't know how to edit so the insulin goal may be off the chart... sorry.

OK -- you are discussing real hormone control NOW!!

Lifespan extension of course is associated with low insulin and the converse is of course try. Not many report their fasting insulin and so far no one has reported the post-prandial insulin which is more diagnostic for hyperinsulinemic states. I would venture everyone would report something > 100 1 or 2 hrs post-prandial after a glucose tolerance test. Like all tests, there is a J-curve. So... some people do have 'low' insulin but it is in reality a reactive 'low'. Not a true baseline low background level kind of low.

Barry Sears like a million years ago proposed these reasons for disease (circa 1999 *haa*):

1) Excess insulin.
2) Excess cortisol.
3) Excess blood glucose.
4) Excess free radicals.

Low carb Paleo eats and movement, n-3, flaxseed oil (+sesame lignans) and a handful of supplements take care of all of the above. Add'l insulin and cortisol control can come also from adrenal support and thyroid support. Sears is actually wrong about some things -- most people now a days are adrenally burnt out just as they are thyroid KAPUT (Hashimoto's thyroiditis). BTW His diet is WAY way too high in carbs and fruit IMHO for insulin support and recovering organs.

My peeps and patients who do Paleo and some supps don't require metformin. In fact, I have had a great # of hypoglycemic reports and had to stop the metformin they have been taking for YEARS. The USDA SAD diet was killing their insulin!!

Like you I do like metformin and use it A LOT (esp the longer acting form that is generic and cheap now). There are some risks with metformin which also take me too long to review. I can't use it in renally compromised people -- and there are a lot of those among the CAD individuals and the itty bitty elderly (MDRD is not a correct estimation for those with low lean muscle mass, e.g. sarcopenia).

-G

Dr. B G said...

Homertobias,

whoops -- ULTRASOUND!

medium-chain-triglycerides.com said...

Hi Dr. B G,
I've seen linoleate referenced by PubMed as an insulin secretagogue here, when compared to MCTs, so while I don't eat polyunsats myself, maybe that's where the subQ fat is coming from. Also here's a study where different fatty acid types reflected differences in storage into adipose tissue.

Why do some studies have MCTs displaying insulinogenic effets and not others? I think a common reason is when the insulin measurements are taken. As you alluded to earlier, it appears to matter whether it's taken in the postprandial or fasted state. Also might have to consider whether the subject was suffering from some ailment, how controlled the diets were...actually no human studies I've seen have been without at SAD-level carbs. I am fairly certain though that 30 mL or so of MCTs will result in a significant insulin response postpradially for most, unless there's some digestive interference going on. I wrote the rest of the comparison on insulin response vs. not here.

Danny Roddy said...

I love the blog Dr. BG.

Your writing makes me laugh and think and I can't thank you enough. Keep up the great work.

Dr. B G said...

Danny!

Hey you ROCKER! Ditto dude!! My whole family has thyroid issues so I have learned SO MUCH from your experiences. Let me know if you play in the Bay Area and us old MILFs will try to break our curfew and attend and be your groupies.

*haaa*

G

metasequoia said...

Hey, what do you know about *unwanted* testosterone & a high saturated fat diet along with resistance training?
I've eaten a very high saturated fat diet (Paleo-ish, low carb) for years now. I started exercising in June, built some amazing muscle & by late August, my hair was thinning. My androstenedione is through the roof. And P.S. I'm a female. I started taking saw palmetto to try to get the andros moving down the pathways - hopefully NOT towards testosterone or DHT - both of which are well within range.

Thanks! I can't find this info *anywhere*.

Dr. B G said...

Metasequoia,

Gosh, I wish I had your problem! The synthetic birth control lowered my Es and T, but I would not recommend them for that purpose (unless you want or cancer).

If the T is off balance, the other hormones may be off balance as well:
--omega-6 to omega-3 balance
--cortisol (adrenal fatigue and depletion)
--thyroid

These come to mind first.

So instead of trying to add DIM or another supplement, consider finding out if the root cause is adrenal, thyroid or omega-3 related.

Consider checking your body temps and heart rates at different times of the day. If you find wide fluctuations betw normal (98.6 F) and low temps (anything < 98.2 F) then you might be looking at both adrenal and thyroid issues. If the temps are just low all the time, then likely only thyroid issues. Higher heart rates may indicated excessive log or high cortisol.

http://www.drrind.com/therapies/metabolic-temperature-graph

The link shows the temperature graphs for both conditions. Both can be 'fixed' with just a few tweaks.

Do you do Crossfit? Are you plugged in? We all do LOTS of fish oil. I had already read everything on fish oil before I started Xfit but my trainer and Robb Wolf really pounded it in. Hunter-gathers ate a lot of omega-3s from diet. Trad'l Inuit eat perhaps ~13 g daily and hardly any omega-6 and they are relatively healthy. For just minimal living/health, Barry Sears and Crossfit advises 2.4 to 3 g daily of EPA DHA (count this from the nutrient facts data on the boxed label).

However, for athletes and others subjected to chronic inflammation -- higher doses are more beneficial. I took a high dose 6-8 grams daily for 2 yrs to shift and the neutralize all the cr*p omega-6s I had eaten my whole life (which contribued caused obesity). Poliquin and Robb have discussed for athletes 0.5 to 1 gram daily per 10 lbs body weight. Lower end if healthy. Higher end if ill. Dosing by Dr. Barry Sears PhD is based on measured inflammation via a blood test known as the n-6:3 ratio with the goal 1.5 to 2.0. He used VERY HIGH doses (10-20+ grams/d) for Dara Torres and Stanford swimmers; her Olympic training included not just swimming but also a lot of resistance training.

I feel your pain if your hair is falling out. Been there too!! Please let me know how it goes and what works for you.

Thanks,
G

Anonymous said...

Hey Dr. BG! Question - why does coconut oil make me feel so hungry? One would think it might fill me up, but I always feel some hunger pains after incorporating it into my meals. Am I not properly digesting it? Also, as I was researching online why it might have this effect, I came across a bunch of stuff about 'oil pulling'. Do you know anything about this? It sounds CRAZY.

Thanks a bunch

Jessica

Dr. B G said...

Jessica,

I'll have to read up on 'oil pulling' as I haven't heard about it. Is it with ALL brands of coconut oil you've tried? Do you have a similiar reaction with virgin, cold-pressed olive oil in meals? Both are fruit oils and can be allergenic, as fruits can sometimes induce food allergies (w/gut dysbiosis, poor nutrition, the SAD diet, etc).

I don't know!

-G

David said...

@Jessica,

Bruce Fife has written a fairly recent book on oil pulling, so you might check that out. I haven't read it, but I've like Fife's stuff in the past.

Also, Dr. Ayers (http://coolinginflammation.blogspot.com)commented on oil pulling at one point, speculating on how it might "work" at improving health. Here's what he said:

"Oil pulling seems to be an attempt to impact biofilms by altering water structure using emulsions. A large amount of oil relative to mouth water is vigorously forced through the teeth to convert a water-oil mixture into an emulsion of structured water next to oil droplets. The result is that little randomly oriented water remains surrounding the polysaccharide matrix that hold the bacteria in the biofilm on the tooth surface. Since the polysaccharide/bacterial agglutinin interaction is primarily hydrophobic and dependent on random water, the bacteria are released from the polysaccharide."


David

Dr. B G said...

David,

Thank you -- as always your a fountain of veritable KNOWLEDGE, resources, energy and YOUTH! Hope your studies are going well!!

Our diet really dictates our microbiome, no?

Take care,
G

David said...

Hey G,

You remember me! Ha! I've sort of disappeared from most of the blogosphere lately, but still try to keep up with most of the goings on when I can. Working on my dissertation now, so that keeps me insanely busy.

Nice to chat with you again. Later!

David

Dr. B G said...

David,

OF COURSE DEAR! I was thinking of you the other day when I was talking to my doc... he's new (to me), he's integrative, and guess what he's a Lyme expert and we were talking about the Klinghardt protocol...

Good luck with your dissertation -- I would be extremely overjoyed and ecstatic if I could see a copy later and see what has been mulling in your wonderful, angelic, and amazing MIND!

-G

Anonymous said...

Dr. G. and David -

Thank you both for your rapid responses, and of course your knowledge!

Dr. G...yes, it's the same for two different coconut oils I've tried, as well as just plain coconut and coconut flour. No, I don't feel the same when I eat cold-pressed EVOO. I have been eating Paleo for well over a year now, so it seems as though my gut should be well on its way to healing, no? Possibly an allergy - I'll have to monitor this some more.

David - thank you for sharing what you know about oil-pulling. This seems interesting, albeit odd. I might do some experimenting down-the-line, when I have dental insurance...I hear it can actually take out metal fillings! ha. We'll see...thanks, again.

Jessica