|(1) Prakash et al, 2011|
The Gut Microbiota and Human Health etc
- digestive capacity:
- AMY1 (amylase in saliva)
- gastric pH
- pancreatic enzymes (elastase)
- gallbladder function
- your microbial allies (see above diagram):
- mutualist aerobes (upper GIT)
- mutualist anaerobes (lower GIT)
- colon fermentive capacity:
- Bugs R US
- fuel for microbes (fiber, RS)
- mucus layer
- SCFA from fiber metabolism by Bugs R US
- luminal and fecal pH (5.8-6.5 'sweet spot')
- colon interior and epithelium association:
- surface and mucus layer (Clostridium, Lactobacillus, Enterococcus)
- lumen (the rest)
|(2) Sekirov et al, 2010|
Gut Microbiota and Human Health
When vital parts and precious pieces are missing, the gut has a difficult time doing what it's supposed to do -- protect you from infections and pathogens,keeping serotonin and melatonin in circulation, recycling cholesterol, and energizing the brain and muscles. In ancient times, the average human likely had an enormous load of microbes from daily exposures compared to modern lifestyles. Think about it? No cold storage -- everything fermented and room temperature. No toilet paper. No C-sections (yes sadly both more moms and babies died). No pesticides or antibiotics which indiscriminately wipe out too many protective microbes. The modern gut is reeling from the deficit of these allies which touch and provide feedback to nearly every immunological, neurological and hormone pathway.
|Petersen, Round, 2014|
(Amoxicillin, Cipro and Vancomycin v. Alterations to Microbiota Ecosystem)
Defining dysbiosis and its influence on host immunity and disease
Clostridiaceae -- massively feeds butyrate/SCFA to colonocytes and immune cells
Eubacteriaceae -- a big RS eater
Ruminococcaceae -- contains the keystone RS degrader
|(3) Marchesi, 2011|
Human Distal Gut Microbiome
So you can see 3 views on the microbes in our gut. Unless you do functional medicine lab testing (GDX, Biohealth, Doctor's Data), all miss the same things: yeasts, parasites, pathogens, and helminth worms. All 3 views show slightly different commensals and mutualists based on slightly different testing methodologies and diverse healthy control subjects that they tested. Actually, I like them all because you can see the variance and diversity and this reflects our ancestry and genetic evolution. What is clear is that research has finally shifted to testing non-healthy subjects and the evidence reveals vast absences in different diseases. Essentially in nearly any disease, researchers find missing mutualists and commensals -- all the above.
Vast extinctions. Empty tropical rainforests. Barren tundras.
Now you are starting be aware of what is gone. What does one have to do to find and recover stolen gems and diamonds? One can't redo birth and squeeze down lactobacilli-coated slides or start licking porcelain bowls which harbor worms or parasites.