Why is there a sudden focus in the media on waist circumferences of 40 inches or greater for men? 36 inches or greater for Asian, Indo-Asian, Pacific-Rim men...
Why is it associated with everything not good for us... Dementia ... Parkinson's Disease... Alzheimer's... Metabolic syndrome... Kidney Disease... Diabetes Mellitus... Heart disease...
And also... erectile dysfunction ? ? It appears that may be the case...
- Riedner CE, Rhoden EL, Ribeiro EP, Fuchs SC. Central obesity is an independent predictor of erectile dysfunction in older men. J Urol. 2006 Oct;176(4 Pt 1):1519-23.
- Vlachopoulos C, Rokkas K, Ioakeimidis N, Stefanadis C. Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links. Eur Urol. 2007 Dec;52(6):1590-600.
- Wirth A, Manning M, Büttner H. [Metabolic syndrome and erectile dysfunction. Epidemiologic associations and pathogenetic links] Urologe A. 2007 Mar;46(3):287-92.
- Müller A, Mulhall JP. Cardiovascular disease, metabolic syndrome and erectile dysfunction. Curr Opin Urol. 2006 Nov;16(6):435-43.
STUDY:
Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. A prospective study of risk factors for erectile dysfunction. J Urol. 2006 Jul;176(1):217-21.
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
PURPOSE: We examined the impact of obesity, physical activity, alcohol use and smoking on the development of erectile dysfunction.
MATERIALS AND METHODS: Subjects included 22,086 United States men 40 to 75 years old in the Health Professionals Followup Study cohort who were asked to rate their erectile function for multiple periods on a questionnaire mailed in 2000. Men who reported good or very good erectile function and no major chronic disease before 1986 were included in the analyses.
RESULTS: Of men who were healthy and had good or very good erectile function before 1986, 17.7% reported incident erectile dysfunction during the 14-year followup. Obesity (multivariate relative risk 1.9, 95% CI 1.6-2.2 compared to men of ideal weight in 1986) and smoking (RR 1.5, 95% CI 1.3-1.7) in 1986 were associated with an increased risk of erectile dysfunction, while physical activity (RR 0.7, 95% CI 0.7-0.8 comparing highest to lowest quintile of physical activity) was associated with a decreased risk of erectile dysfunction. For men in whom prostate cancer developed during followup, smoking (RR 1.4, 95% CI 1.0-1.9) was the only lifestyle factor associated with erectile dysfunction.
CONCLUSIONS: Reducing the risk of erectile dysfunction may be a useful and to this point unexploited motivation for men to engage in health promoting behaviors. We found that obesity and smoking were positively associated, and physical activity was inversely associated with the risk of erectile dysfunction developing.
When I first started working as a pharmacist, Viagra had just come out. The NP I was working with asked that I consult one of her patients. She asked me about the drug's indications, side effects and contraindications... and we used scientific terminology... like... plumbing... tent-in-the-pants... morning w**d... Then I went and met with the patient to review how to properly take the medication (yeah... fun). At the time, it was not realized that this class of medications (known as PDE inhibitors) had more serious side effects like rare blindness and (more rare) hearing loss. Oddly, one may also change blue-eyes to brown (unfortunately not the other way around).
Viagra, Levitra, or Cialis typically need to be taken prior to ... uhh... provocation. In other words, they don't just work while standing at the kitchen counter chopping vegetables... particular thoughts need to occur first.
Is it necessary to rely on these medications?
Why not prevent vascular disease early in the 20's and 30's and 40's?
Would you want to wait around for E.D. (erectile dysfunction) and vasculature obstructions to affect the function of reproductive organs? Or brain? Or heart?
Some evidence shows that ED may be equivalent to coronary artery disease and plaque.
Just as we are aware in the TYP program that plaque is modifiable (as Dr. Davis recently presented at the FASEB meeting), several trials have shown that ED is measurably modifiable. I think to myself... what a wonderful world? Solutions for reversible conditions exist in the TYP plan including erectile dysfunction.
Factors that have been shown to improve ED are:
- Exercise -- promotes improved circulation, increases the body's inherent antioxidants and reduces systemic inflammation
- Smoking cessation
- Losing weight
- Reducing excessive alcohol
- Relaxation
- L-Arginine (a special amino acid/protein supplement)
- Anything that reverses coronary plaque (ie, the TYP program including all the above)
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- Görge G, Flüchter S, Kirstein M, Kunz T. [Sex, erectile dysfunction, and the heart: a growing problem] Herz. 2003 Jun;28(4):284-90. Review. German.
- Billups KL. Erectile dysfunction as a marker for vascular disease. Curr Urol Rep. 2005 Nov;6(6):439-44.
- Kirby M, Jackson G, Simonsen U. Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract. 2005 Feb;59(2):225-9.
- Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005 Dec 21;294(23):2996-3002.
- Chiurlia E, D'Amico R, Ratti C, Granata AR, Romagnoli R, Modena MG. Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. J Am Coll Cardiol. 2005 Oct 18;46(8):1503-6.
- Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, Briganti A, Salonia A, Dehò F, Rigatti P, Montorsi F, Fiorentini C. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. Eur Heart J. 2006 Nov;27(22):2632-9.
- Montorsi P, Ravagnani PM, Galli S, Salonia A, Briganti A, Werba JP, Montorsi F. Association between erectile dysfunction and coronary artery disease: Matching the right target with the right test in the right patient. Eur Urol. 2006 Oct;50(4):721-31.
- Min JK, Williams KA, Okwuosa TM, Bell GW, Panutich MS, Ward RP. Prediction of coronary heart disease by erectile dysfunction in men referred for nuclear stress testing. Arch Intern Med. 2006 Jan 23;166(2):201-6.
- Elesber AA, Solomon H, Lennon RJ, Mathew V, Prasad A, Pumper G, Nelson RE, McConnell JP, Lerman LO, Lerman A. Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis. Eur Heart J. 2006 Apr;27(7):824-31.
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- Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology and the role of novel risk factors: a clinicobiochemical perspective. Angiology. 2007 Oct-Nov;58(5):513-22.
- Francavilla S, Bocchio M, Pelliccione F, Necozione S, Francavilla F. Vascular aetiology of erectile dysfunction.Int J Androl. 2005 Dec;28 Suppl 2:35-9.
- Jackson G, Rosen RC, Kloner RA, Kostis JB. The second Princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine. J Sex Med. 2006 Jan;3(1):28-36; discussion 36.
- Masuda H. Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction.
Int J Urol. 2008 Feb;15(2):128-34. - Bivalacqua TJ, Hellstrom WJ, Kadowitz PJ, Champion HC. Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction. Biochem Biophys Res Commun. 2001 May 18;283(4):923-7.
- Baylis C. Nitric oxide deficiency in chronic kidney disease. Am J Physiol Renal Physiol. 2008 Jan;294(1):F1-9.
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Read the TYP report for more erectile dysfunction and CAD.
Or DR. Davis's LEF.org article
Sarah Brightman:
What A Wonderful World
Live in Vegas, Courtesy of Youtube.com
Gams, lambs, dam... damsel/princess/fairy-goddess! Here she is again, Sarah Brightman. The video is not-extremely-nsfw, but... your w**dy... will be...
1 comment:
good article LOL
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