Wednesday, April 29, 2009

Raving/Raging More On Vitamin D: DOSING

Once people start on appropriate doses of vitamin D... And...I am not referring to LICKING A CAPSULE, they come up to me and tell me HOW GREAT THEY FEEL.

More energy, more vitality and feeling younger.

In only o n e w e e k. Wowo.


Vitamin D is certainly a steroid precursor which has benefits for everyone. Not just athletes.



Who Frequently Needs Higher Doses?

I've broken this down to a few subgroups from my experience:
--Leaky gut (these benefit highly from the protective/healing effects of probiotics+digestive enzymes combined)
--Morbidly obese (but not necessarily)
--Again, those with leaky gut -- those still consuming WHEAT (and/or casein if sensitive)
--Genetically those who may be fast-metabolizers. Who r u? I have no idea. Ck your blood levels and if it does not respond in 6-8wks, you may be one of them. Hx Rickets? Hx Grave's? Hx Hashimoto's??
--Drugs which increase metabolism, disposal, elimination of fat-soluble drugs, xenobiotics and VITAMINS ADEK omega-3s EPA DHA -- anti-seizure drugs Valproic acid, Depakote, Carbamazepine and others incl Calcium channel blockers
--Those taking stupid drugs like Xenical or ALLI which block fat absorption (or ?Zetia as well hypothetically)




Contraindications to Vitamin D Therapy

If your blood levels of 1,25 OHD (calcitriol, one of the active metabolites) or 25-OH-D (calcidiol, another active metabolite) are fine or elevated, then you don't need supplementation.
--Plenty of sunlight exposure (esp equatorial, esp midday, esp when "your shadow is shorter than you are" per Dr. Cannell)
--Frequent naked *winky*, clothes-less, makeup-less, sunscreen-less exposure
--Dialysis patients already taking Rx Calcitriol where blood levels are optimal which they hardly ever are. Current national DOQI guidelines are to include Vitamin D supplementation and to achieve 25OHD blood concentrations appropriately.


Who should absolutely not receive supplementation?
--Sarcoidosis (already high calcitriol from inappropriate secretion secondary to autoimmune proliferative changes)
--Some weird malignant cancer where the cells are overproducing either calcitriol or calcidiol



Dosing

No... 100 IU Vitamin D from a cup of casein-milk will not get anyone ANYWHERE.

Babies from Day One are advised now from the Academy of Pediatrics to receive orally 400 IU daily (this is DOUBLE from prior recommendations of 200 IU daily) either from supplementation drops, formula (1-2 cups daily? wtf), or Momma's milk (if Momma chooses to improve her baby's health to supplement herself since 99% of Momma's are ALL also deficient).

Clover Organic Farms Milk
(reduced fat, whole, or nonfat)
Vitamin D3 content = 100 IU (25% of RDA) in one cup = 8 oz




Why Milk Even Contains Vitamin D

For the treatment of rickets in the early 1900's, the U.S. mandated vitamin D 400 IU to be added to every quart of milk (4 cups).

Let's say my minimal requirement for vitamin D is 5000 IU, barring any UVB exposure where typically a human would receive 99% of vitamin D sources (food provides less than 30-100 IU per serving like dairy, fish, liver, caviar or otherwise).

I would have to drink 50 (eg, F I F T Y) cups of milk to provide what my growing (ghetto fab/PHAT/HAWT) body would need...


FIFTY.


Milk isn't even Paleo.

Milk... Don't do it.

BTW...Casein, one of the main proteins in dairy sources, has been linked to many autoimmune disorders in susceptible folks (eg, autism, ADD, MS, Hashimoto's, RA, Sjogren's, Migraines, Type 1 Diabetes, Uveitis, IBD, Cholangitis, NASH/Liver Cirrhosis, etc). ??? CAD probably too.
Range of neurologic disorders in patients with celiac disease.
Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism.
Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology.
Collagen disease: the enemy within.
Possible immunological disorders in autism: concomitant autoimmunity and immune tolerance.
Enterococci in milk and milk products.(and migraines)
[Cerebral calcifications: a clue for a diagnostic process in a nonspecific clinical case] (migraine)
[Primary headaches and the influence of inflammatory diseases of the CNS and their respective immunmodulatory therapy]
The neurology of gluten sensitivity: separating the wheat from the chaff.
Antibodies to bovine beta-casein in diabetes and other autoimmune diseases.
Cell-mediated immune responses to GAD and beta-casein in type 1 diabetes mellitus in Thailand.
Autoimmune uveitis and antigenic mimicry of environmental antigens.
Serum antibodies to cow's milk folate-binding protein in patients with chronic inflammatory bowel disease.
Autoimmune cholangitis in the SJL/J mouse is antigen non-specific.
IgA antibodies to dietary antigens in liver cirrhosis.
Evolutionary distance from human homologs reflects allergenicity of animal food proteins.
Relationship between naturally occurring human antibodies to casein and autologous antiidiotypic antibodies: implications for the network theory.
Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula.

6 comments:

Dawn D. said...

Excellent post , G!

Let's start "tweeting" about TYP. You are sooooo good with your blogs.

Dawn D.

Marisa said...

I just wanted to tell you how right you are about vit D dosing. I thought my baby was getting sufficient vit D through my breastmilk b/c I was solely nursing, and b/c I was supplementing at such a high dosage (20k i.u.). Of course, I have leaky gut and haven't been able to get my vit D levels to the optimum level of 65 ng (last checked it was 40 ng). Although she was an alert baby that didn't show any abnormal developmental progress, looking back I can see that she was vit D deficient.

At 14 mos, she was taking her first frankenstein steps, was very docile and on a good schedule. Although she dragged her right foot as she walked, it wasn't so abnormal as to have us worry (we have a child mildly on the autistic spectrum and she was our 4th). At this point she contracted hand-foot-mouth syndrome, courtesy of another child at an indoor playground. To speed her recovery I decided to supplement her vit D according to recommendations of 1k i.u. per body weight for the first 3 days.

Well, the next few days we saw an awakening, as if she'd been in a coma. She became more alert, more interactive, and began walking with such proficiency. The drag from her right foot disappeared, and she began communicating with more gestures. Perhaps all this was part of the normal developmental trend, but it seems so pivotal at that time of illness, lethargy, and great developmental milestones.

It's so odd that our whole family had been supplementing vit D at this point, and yet our infant was vit D deficient.

Keep doing what you're doing, and getting the word out there. Those with ears are listening. Don't throw your pearls before swine. and Thank you for your vivacious and vigilant care!

Dr. B G said...

Hey Dawn!!

Don't forget to ck out the Warrior Race post... it's for YOU too... *haa*

I'm so lowtech... a total TWAT about twitter... But I'll keep TWEETING ABOUT TYP!!

-G

Dr. B G said...

Hi Marisa,

Your stories and sharing are always so wonderful. THANK Y-O-U !

Love, G

taz said...

the milk proteins implicated in those diseases tended to be A1 casein, whereas the milk drunk traditionally by people like the mongolians, masai, etc comes from animals with only A2 protein

Dr. B G said...

Taz,

Seriously?!?!

Goats' and human B**BS' milk is... A2.

I've been totally wondering about the Masai 'contradiction'...

THANK YOU!

-G

Diabetologia. 1999 Mar;42(3):292-6.

Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consumption.Elliott RB, Harris DP, Hill JP, Bibby NJ, Wasmuth HE.
Department of Paediatrics, School of Medicine, Auckland, New Zealand.

Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition information and low dairy imports from other countries. Total protein consumption did not correlate with diabetes incidence (r = +0.402), but consumption of the beta-casein A1 variant did (r = +0.726). Even more pronounced was the relation between beta-casein (A1+B) consumption and diabetes (r = +0.982). These latter two cow caseins yield a bioactive peptide beta-casomorphin-7 after in vitro digestion with intestinal enzymes whereas the common A2 variant or the corresponding human or goat caseins do not. beta-casomorphin-7 has opioid properties including immunosuppression, which could account for the specificity of the relation between the consumption of some but not all beta-casein variants and diabetes incidence.

PMID: 10096780