Sunday, January 11, 2009

Bone Marrow: Immunoprotective and Improves Endothelial Dysfunction

Chicken Soup. Do you love it?


Do you know scientifically and medically why it's so beneficial and therapeutic (better than a FLU SHOT)?

What satisfies the soul and combats colds, infections and vascular atherosclerosis (CAD, PVD, PAD, CVD, CKD)?

Bone marrow derived endothelial progenitor cells (EPCs)!!! From bone marrow.

(preferable organic, 80%+ grassfed, from Whole Foods or a reputable ranch)

Pharmacological approaches to improve endothelial
repair mechanisms.

Besler C, Doerries C, Giannotti G, Lüscher TF, Landmesser U.
Expert Rev Cardiovasc
Ther. 2008 Sep;6(8):1071-82. Review.
PMID: 18793110

Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland.

Endothelial injury is thought to play a pivotal role in the development and progression of vascular diseases, such as atherosclerosis, hypertension or restenosis, as well as their complications, including myocardial infarction or stroke. Accumulating evidence suggests that bone marrow-derived
endothelial progenitor cells (EPCs) promote endothelial repair and contribute to ischemia-induced neovascularization. Coronary artery disease and its risk factors, such as diabetes, hypercholesterolemia, hypertension and smoking, are associated with a reduced number and impaired functional activity of circulating EPCs. Moreover, initial data suggest that reduced EPC levels are associated with endothelial dysfunction and an increased risk of cardiovascular events, compatible with the concept that impaired EPC-mediated vascular repair promotes progression of vascular disease. In this review we summarize recent data on the effects of pharmacological agents on mobilization and functional activity of EPCs. In particular, several experimental and clinical studies have suggested that statins, angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor blockers, PPAR-gamma agonists and erythropoietin increase the number and functional activity of EPCs. The underlying mechanisms remain largely to be defined; however, they likely include activation of the PI3-kinase/Akt pathway and endothelial nitric oxide synthase, as well as inhibition of NAD(P)H oxidase activity of progenitor cells.

The above seminal article suggests that bone marrow may hold the key to improving endothelial problems and inflammation. The astute authors suggest the below pharmaceuticals would be helpful. What are the food analogues if we had to 'deconstruct' these drug components they allude to? Would food be safer? Better? More efficacious? Yes... I belive so. Not just because your momma made it! :)

--Statins: How about fish oil? how about veggie-fibers? how about chol/sat fats? How about plant sterols (like in butter oil)?
--Angiotensin-converting enzyme inhibitors: How about Taurine, L-Arginine (like contained in nuts and seafood/meat?)? how about other essential proteins glutamic and aspartic acid, lysine, hydroxylysine and histidine?
--Angiotensin II type 1 receptor blockers: How about Glycine, Taurine?
--PPAR-gamma agonists: How about high dose EPA DHA fish oil ALA/flaxseed oil? how about Taurine/Leucine proteins? how about exercise/ IF/ starving occasionally? sat fats? how about CLA (like in meat and butter oil)? how about meat-derived Carotenoids which synergize PPAR effects? how about Lutein/eggs? Astaxanthin? Krill oil?
--Erythropoietin: How about eating b o n e m a r r o w ?

Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules.
Das UN.
Lipids Health Dis. 2008 Oct 15;7:37. Review.
PMID: 18922179

Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.
Paumelle R, Staels B.
Circ Res. 2007 May 25;100(10):1394-5. No abstract available.
PMID: 17525375

What does Bone Marrow contain which is so nutrient dense and fabulously fantastic?
--Hormones: Testosterone, Estrogen, Progesterone, Human Growth Hormone
--Vitamin A D E K
--EPO (erythropoitin)
--Minerals: Magnesium, Calcium, Zinc, etc
--Saturated Fats
--Proteins: L-Arginine (which lowers BP in pre-eclampsic women), Glutamate, Aspartic acid, Lysine, Hydroxylysine and Histidine
--EPCs (endothelial progenitor cells) which improve our BLOOD VESSELS and promote better CIRCULATION AND BLOOD FLOW and healthier endothelium
--Serotonin, mood neurotransmitter (yes, SSRI antidepressants are highly associated with osteoporosis and nonvertebral fractures as we 've recently learned HERE and HERE and HERE); some people reported getting 'high' on bone marrow like marine biologist Dr. Dan, perhaps this is why? Marrow Madness and Its Hidden Secrets

Wow. My cat who can eat whole mice and their lovely bones knows what she's doing!

Peter's fans (eg, Anna of Against the Grain) have listed optimal bone feeding of cats HERE.


Isabella said...

Thought you might be interested in this blog posting:

He asked the answered it!

Love your blog. I learn so much every time I read it.

Anonymous said...

ha that would explain it. I am about to have breakfast and guess what Im having. I have a marrow addiction I swear.

Dr. B G said...

Hi Isabella,

Yes -- I saw that!

I'm so glad there are so many great informative resources and blogs out there now...and cool people realizing the differences in paradigms.


Dr. B G said...

Hey Dan!

MMMmmmhhhmmm, yes the food picts look mouth-watering!

Strong work on your physical and nutrional transformation. Thanks for posting your progress!! I'm sure it helps many people!