Showing posts with label Bone Marrow. Show all posts
Showing posts with label Bone Marrow. Show all posts

Thursday, October 20, 2011

Homo Purgare


'Angel' Feral Kitten: Alloparenting
Here's Angel our feral kitten that we fostered for a couple of weeks until she could eat solids on her own. My kids brought her home one day from the pet store where she was apparently dropped off. My kids are in fact anaphylactically allergic to cats yet cannot seem to stay away from them (KITTYCR*CK). At ~ 4 weeks old she was the size of a teacup. I've been busy and we just gave her back this week to be adopted hopefully at the store. In the beginning she had to be handfed softened food every 2 hours and had diarrhea. My kids and I gave her fish oil, probiotics (Flora Balance) and vitamin D supplements as well and as a result the diarrhea ended and she apparently grew like the carnivore that she is! When she first arrived, she walked with a wobbly gait and hopped on her hind legs like a d*ng bunny, but now at 8 weeks old she strides fast and long, like a predator ...bites like one too... then disappears into thin air.


Lactation and Weaning

It is interesting how quickly carnivores are weaned from their mothers and adapt to solid and semi-solid foods compared to primates. Kennedy reports that 'Though humans have a longer period of infant dependency than other hominoids, human infants, in natural fertility societies, are weaned far earlier than any of the great apes: chimps and orangutans wean, on average, at about 5 and 7.7 years, respectively, while humans wean, on average, at about 2.5 years.' Why? Because we're predators, not bunnies.


HunterAngel acts like a predator, day and night. She practices hunting, capturing and stalking her prey. Only predators are playful in the animal kingdom. Here is a picture, she leaped 12-18 inches to grab the camera flash! Other targets including our face, our feet and plump fingers! I have dozens of microscropic puncture wounds from her lovely feral baby claws. After her nails were clipped, it wasn't so painful playing with her. Naturally she practices HIIT -- bursts of hyperactivity and playful brutality with our body parts or her toys, then long, extended naps. She's young and sleeps all day. Unfortunately the pet store feeds the S.A.D. version of cat-kibble, but with us she was given something similar to the below Canadian brand and real food (raw yolks, meat, bone broth).

Orijens: 'biologically appropriate' (grain-free) food for cats and dogs sourced from free-range meat or wild-caught seafood (80/20/0 = meat/vegfruit/grain).



Homo Purgare, Scavenger

Somewhere in our hominid timeline, humans have regressed and are de-evolving -- our guts, our brains, our skeletal system, our fertility/gonads... See top. Like captured predators, zoo humans eat pre-digested and refined, mass manufactured 'food'. Where's our playfulness? Our carnivory lifestyles? The RAW?? On forums and digital savannahs??? Recently we moved from the cement suburbia into the cement jungle of the big city of Shanghai... A lot of adjustments but in some ways neat adventures for us.

Purgare is Latin for 'to clean' (according to my handy dandy Latin dict) or to salvage or scavenge. [please correct me!] Are we as a species in the modern, tech age and interstate/intercountry commerce, more homo purgare than sapien sapien ('doubly wise')?

Milton states that 'As human evolution progressed, young children in particular, with their rapidly expanding large brain and high metabolic and nutritional demands relative to adults would have benefited from volumetrically concentrated, high quality foods such as meat [and fat, I say]. Today, many humans, particularly those in high income nations, have a variety of high quality, non-ASF [animal sourced food] dietary alternatives, but such foods were not generally available to paleolithic human ancestors nor to many people today in low income nations.' Yes. GMO soy products, formula, hydrized high-gluten wheat, GMO rice and refined packaged foods are not available in some third world countries but that is rapidly changing. Big Agra and Fast Food Nation have hit. India, China and Africa are besot with mass produced, manufactured foods now and it shows. Feedlot eggs, dairy, poultry and meat are commonplace as well. Fields of GMO rice and crops growing on vast landscapes (on industrial waste typically, like Pearl River). Obesity and T2DM are epidemic, especially in China where the rule is one child per family, leading to 3 sets of over-feeding influences (parents, 2 sets of grandparents).

Courtesy Youtube.com
ATB ft Tiff Lacey - Ecstasy (Chill In The Sunrise Mix)
Predator of Prized Brain Nutrients Admittedly, Angel's never going to hunt except a few lost flies or mosquitoes, unless she escapes to the outdoors. We did let her scavenge at the dinner table with my kids alloparenting her with pre-chewed scraps (and human mouth flora!)... Going back to Kennedy... Competition with other carnivores (like Angel's predecessors like saber tooth tigers, leopards, etc) may have encouraged selection for earlier weaned humans and scaling the care-giving role from mother to extended family or pack members. What were the nutrients they were competing for? Kennedy argues that acquisition of protein (and thus fats) selected for brain survival and early weaning. Like carnivores, mother's milk wasn't enough to continue growing the predator brain. Like some carnivores, one, single mother alone wasn't enough and alloparenting evolved. Humans are mega-caregivers for long-lived offspring requiring intensive rearing, as well as mega-consumers of specific brain nutrients from protein sources: omega-3, minerals, amino acids, fats. It's a curious combination deeply forged in evolution. Eating tongue-to-testicle and muzzle-to-marrow are the only ways to source the required nutrients for optimal brain maturation and growth. For predators with big brains.
"Assuming that living great apes demonstrate the ancestral weaning pattern, modern humans display a derived pattern that requires explanation, particularly since earlier weaning may result in significant hazards for a child. Clearly, if selection had favored the survival of the child, humans would wean later like other hominoids; selection, then, favored some trait other than the child's survival. It is argued here that our unique pattern of prolonged, early brain growth--the neurological basis for human intellectual ability--cannot be sustained much beyond one year by a human mother's milk alone, and thus early weaning, when accompanied by supplementation with more nutritious adult foods, is vital to the ontogeny of our larger brain, despite the associated dangers. Therefore, the child's intellectual development, rather than its survival, is the primary focus of selection. Consumption of more nutritious foods--derived from animal protein--increased by ca. 2.6 myr ago when a group of early hominins displayed two important behavioral shifts relative to ancestral forms: the recognition that a carcass represented a new and valuable food source-potentially larger than the usual hunted prey-and the use of stone tools to improve access to that food source. The shift in the hominin "prey image" to the carcass and the use of tools for butchery increased the amount of protein and calories available, irrespective of the local landscape. However, this shift brought hominins into competition with carnivores, increasing mortality among young adults and necessitating a number of social responses, such as alloparenting. The increased acquisition of meat ca. 2.6 Ma had significant effects on the later course of human evolution and may have initiated the origin of the genus Homo."
References: 1. Boaz N. Eco Homo. 1997. Basic Books. [Chapter One, NYT] 2. Shlain L. Sex, Time and Power. 2003. Penguin, New York, NY. 3. Switek B. Written in Stone: Evolution, the Fossil Record and Our Place in Nature. 2010. Bellevue Literary Press, New York, NY. 4. Cunnane S. Survival of the Fattest: The Key to Human Brain Evolution. 2004. World Scientific. 5. From the ape's dilemma to the weanling's dilemma: early weaning and its evolutionary context. Kennedy GE. J Hum Evol. 2005 Feb;48(2):123-45. 6. Meat-adaptive genes and the evolution of slower aging in humans. Finch CE, Stanford CB. Q Rev Biol. 2004 Mar;79(1):3-50. 7. The critical role played by animal source foods in human (Homo) evolution. Milton K. J Nutr. 2003 Nov;133(11 Suppl 2):3886S-3892S. Internet sources: http://www.nytimes.com/2011/09/25/opinion/sunday/is-junk-food-really-cheaper.html?_r=3&pagewanted=1 http://www.msnbc.msn.com/id/12721432/ns/technology_and_science-science/t/ancient-die-off-blamed-climate-not-humans/ http://www.beringia.com/centre_info/exhibit.html http://www.onelife.com/evolve/index.html http://www.beyondveg.com/nicholson-w/hb/hb-interview1c.shtml http://www.thefutureoffood.com/resources.html Alloparenting -- John Hawks Neolithic Equids -- Why the Long Face? Jamie Scott, That Paleo Guy posthttp://www.bio.davidson.edu/people/vecase/behavior/Spring2009/Landfried/index.html http://www.biology-online.org/articles/alloparenting-what.html

Sunday, January 11, 2009

Bone Marrow: Immunoprotective and Improves Endothelial Dysfunction

Chicken Soup. Do you love it?

Why?

Do you know scientifically and medically why it's so beneficial and therapeutic (better than a FLU SHOT)?



What satisfies the soul and combats colds, infections and vascular atherosclerosis (CAD, PVD, PAD, CVD, CKD)?

Bone marrow derived endothelial progenitor cells (EPCs)!!! From bone marrow.

(preferable organic, 80%+ grassfed, from Whole Foods or a reputable ranch)



Pharmacological approaches to improve endothelial
repair mechanisms.

Besler C, Doerries C, Giannotti G, Lüscher TF, Landmesser U.
Expert Rev Cardiovasc
Ther. 2008 Sep;6(8):1071-82. Review.
PMID: 18793110

Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland.

Endothelial injury is thought to play a pivotal role in the development and progression of vascular diseases, such as atherosclerosis, hypertension or restenosis, as well as their complications, including myocardial infarction or stroke. Accumulating evidence suggests that bone marrow-derived
endothelial progenitor cells (EPCs) promote endothelial repair and contribute to ischemia-induced neovascularization. Coronary artery disease and its risk factors, such as diabetes, hypercholesterolemia, hypertension and smoking, are associated with a reduced number and impaired functional activity of circulating EPCs. Moreover, initial data suggest that reduced EPC levels are associated with endothelial dysfunction and an increased risk of cardiovascular events, compatible with the concept that impaired EPC-mediated vascular repair promotes progression of vascular disease. In this review we summarize recent data on the effects of pharmacological agents on mobilization and functional activity of EPCs. In particular, several experimental and clinical studies have suggested that statins, angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor blockers, PPAR-gamma agonists and erythropoietin increase the number and functional activity of EPCs. The underlying mechanisms remain largely to be defined; however, they likely include activation of the PI3-kinase/Akt pathway and endothelial nitric oxide synthase, as well as inhibition of NAD(P)H oxidase activity of progenitor cells.


The above seminal article suggests that bone marrow may hold the key to improving endothelial problems and inflammation. The astute authors suggest the below pharmaceuticals would be helpful. What are the food analogues if we had to 'deconstruct' these drug components they allude to? Would food be safer? Better? More efficacious? Yes... I belive so. Not just because your momma made it! :)

--Statins: How about fish oil? how about veggie-fibers? how about chol/sat fats? How about plant sterols (like in butter oil)?
--Angiotensin-converting enzyme inhibitors: How about Taurine, L-Arginine (like contained in nuts and seafood/meat?)? how about other essential proteins glutamic and aspartic acid, lysine, hydroxylysine and histidine?
--Angiotensin II type 1 receptor blockers: How about Glycine, Taurine?
--PPAR-gamma agonists: How about high dose EPA DHA fish oil ALA/flaxseed oil? how about Taurine/Leucine proteins? how about exercise/ IF/ starving occasionally? sat fats? how about CLA (like in meat and butter oil)? how about meat-derived Carotenoids which synergize PPAR effects? how about Lutein/eggs? Astaxanthin? Krill oil?
--Erythropoietin: How about eating b o n e m a r r o w ?


Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules.
Das UN.
Lipids Health Dis. 2008 Oct 15;7:37. Review.
PMID: 18922179

Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.
Paumelle R, Staels B.
Circ Res. 2007 May 25;100(10):1394-5. No abstract available.
PMID: 17525375


What does Bone Marrow contain which is so nutrient dense and fabulously fantastic?
--EPA + DHA
--Hormones: Testosterone, Estrogen, Progesterone, Human Growth Hormone
--Vitamin A D E K
--EPO (erythropoitin)
--Minerals: Magnesium, Calcium, Zinc, etc
--Saturated Fats
--Proteins: L-Arginine (which lowers BP in pre-eclampsic women), Glutamate, Aspartic acid, Lysine, Hydroxylysine and Histidine
--EPCs (endothelial progenitor cells) which improve our BLOOD VESSELS and promote better CIRCULATION AND BLOOD FLOW and healthier endothelium
--Serotonin, mood neurotransmitter (yes, SSRI antidepressants are highly associated with osteoporosis and nonvertebral fractures as we 've recently learned HERE and HERE and HERE); some people reported getting 'high' on bone marrow like marine biologist Dr. Dan, perhaps this is why? Marrow Madness and Its Hidden Secrets


Wow. My cat who can eat whole mice and their lovely bones knows what she's doing!

Peter's fans (eg, Anna of Against the Grain) have listed optimal bone feeding of cats HERE.