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Pharmacology effect of ancestral food + lifestyles on human animals (aka poop princess) #gut #SBO #soil #disease #autoimmune #probiotics #microbiota #7steps #RS

Transcendance: Practicing Evolution (Bruce Lipton PhD)

Agri-Dynamics: Jerry Brunetti

I have no idea who this is but I've researched topics lately and his name popped up numerous times. Melissa discussed briefly in her Wise Traditions Recap: HERE. Brunetti is doing some kind of wonderful work regarding meat sourcing and good pastured livestock.

Two excellent slide presentions I happened to flip across by Brunetti are below, which scintillate down why good gut flora maintenance is of the utmost importance and how DIET DIET DIET and nutraceuticals can cure/reverse/improve gut imbalances caused by drugs, antibiotics, bad-nonpastured-meat, modern living, S.A.D. high carb/high grain diets. The value of digestive, pancreatic enzymes are also discussed.

• Health From The Gut Up, Jerry Brunetti
• The Link Between Nutrition, Jerry Brunetti

What I Liked About Brunetti's Slides

In the first slide these are the points I enjoyed the most below and in the second, the list of resources and books is fantastic.

--slide 22 and 23 are EXCELLENT
--slide 42 explains indicanuria -- intestinal toxemia on sophisticated diagnostic lab testing (neurologic, GI, skin, and every organ system with chronic conditions described)
--slide 61 treatment strategies incl pre- probiotics, betaine, digestive enzymes (previously I discussed the value and role enzymes under NEOLITHIC CHEATING)
--slide 63 Brent's relative Dr. Pottenger mentioned -- adding gelatin for glycine which is gut healing/improves glutathione/anti-inflammatory, etc




Role of Politics: Food Business

WAP-Pottenger are great -- I wish I had known about the value of traditional eating before I had my children and given them the epigenetic benefits of our Hakka and asian genes. Though I know it is not too late, what we all fight against as parents is indeed the government. This is a common theme to paleo parents I've had the opportunity to talk in depth with. We fight sanctioned USDA food choices in the school cafeteria and the all pervasive USDA grain-based-6-to-11-servings-daily food pyramid of TOXIC POISON which are then perverted and pimped by food processing companies and television commercials. Even well-intentioned family and friends try to push their CRACK on my children. Yes. Expected but yet annoying.

As a parent, hard to be challenged against all that... not to mention the frequent cake, pizza and juice/soda parties and social events. Yes my kids will say 'no' to illegal drugs but legalized P I Z Z A, which is more addictive than CRACK ??!


Government Solutions? Not Holding Breath

The permanence of the current food policies are cracking but will it happen soon enough? Even Andrew Weil is pushing a more grain-free diet approach that is lower in dangerous refined carbohydrates. Yes. See his July HuffPo post: "The saturated fat lauded in this menu [of an establishment in Arizona known as the *chuckle* Heart Attack Grill] won't kill you. It may even be the safest element of the meal... If you visit, I implore you to steer clear of the white-flour buns, the sugary sodas and the piles of "flatliner fries..."

Yes. Additionally in the HuffPo, Weil promotes and advocates Gary Taubes and the body of evidence in GCBC.

This is exciting because as far as I am aware Dr. Weil is involved with the only integrative medicine program in the medical academic training program. R U Considering med school and being indoctrinated in prescribing gluten CRACK?? Even Weil's program is mutating to reason and SANITY. *haa ah!*



Bruce Lipton and Steve Bhaerman: Transcendent Solutions, Practicing Evolution

In one of the last chapters in Bruce Lipton's recent seminal work, co-authored with Steve Bhaerman, called 'Spontaneous Evolution,' negotiations and problem solving become the core focus. He puts it succinctly 'A primary function of politics is to develop policies that preempt conflict. Conflict is a natural part of human lfe and social interactions and should not be confused with violence, which is the most dysfunctional way to handle conflict. Conflict derives from incompatabilities between two or mroe opinions, principoles or interests. Because conflict usually involves contradictory goals, resuoltuion can occur when something -- the goals or expectations regarding those goals -- is changed.' Obviously he states 'careful and respectful listening by all participants is required...' and how to arrive at ideal problem solving he consults negotiation experts like Norwegian Johan Galtung who seek 'the fifth way' or 'fivers'. Galtun was the mediator in the Peru-Ecuador border negotiations (solution: no borders). Galtung pushes that each conflict has 5 potential remedies:

1. I win. You lose
2. You win. I lose.
3. Negative Transcendence in which the problem is solved by avoiding it entirely
4. Compromise in which each wins by agreeing to lose a little
5. Transcendence, which produces a resolution above and beyond the problem.




Indiana Farmer and His Sheep

Lipton and Bhaerman tell wonderful, clever stories. They recount how an Indiana farmer found the neighbor's dogs killing all his herds of sheep. 'Too often the way of solving such problems involved confrontation, threats, lawsuits, barbed wire fences, and, potentially, shotguns. This particular farmer had a better idea. He gave his neighbor's children lambs as pets. This out-of-the-box solution established a win-win proposition: for the sake of the children's adorable pets, the neighbors voluntarily tied up their dogs, and the families became friends.'



Collectively We Face Exciting Times

Paleo people want change. Fat people want change (because they (and previously ME) eternally keep buying 'diet books'). Unhealthy people want change. Right? Maybe...

Something is changing (*haa ah* Dr.Oz with polyps is useless and Oprah has gained weight again) and hopefully we won't have to wait forever.

I've found paleo people to be extremely transcendant and clever... Thoughts... solutions?

Shawn Mullins and The Thorns:
No Blue Sky

Abs 2 Die 4...FAQs

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Our Paleo Princess-Party!

Our first wheat-free birthday party occurred a few weeks ago. Needless to say it required a little more preparation than previous parties!

Fortunately I was really inspired by Anna and her wonderful coconut flour chocolate cookies and the rest of the menu became easy. Anna's original recipe is here where she also includes some great low-carb cooking ideas. When I went to Whole Foods to gather the ingredients, I discovered quite at the last minute that they did not carry the primary ingredient... the coconut flour! So instead we improvised and had almond chocolate chip cookies instead. Apparently they were a hit (or... the princess swimmers were just really really HUNGRY). (warning: The cookie dough had a weird grassy unpleasant smell from the garbanzo bean flour (I presume) but it all disappeared while baking.)

The cookies smelled and looked and tasted even better than REAL CHOCOLATE CHIP COOKIES. (even without the primary ingredient!!)


Improvised Almond Choco-chip Butter Cookies (Courtesy of Anna -- I'm her biggest fan)

1/2 cup butter (1 stick), very soft or slightly melted and creamy (I should've used MORE)
1/4 cup sugar
1 teaspoon vanilla
1 teaspoon almond extract
4 eggs
1/2 cup garbanzo bean flour
1/2 cup almond meal/flour
1/2 cup oat flour
1/2 cup unsweetened grated coconut: fine, coarse or combination

1/2 cup gluten-free tiny-sized semi-sweet chocolate chips (or up to 1 cup)

Makes 24 cookies
Preheat oven to 425°F (Convection; or 400°F regular). Cover cookie sheet with aluminum (or Silpat silicone mat).

Mix together soft butter and sugar. Add eggs and vanilla and almond extract; mix well.

Add all flours and grated coconut; mix well.

Drop cookie dough by spoonfuls or dough scoop onto pan one inch apart (cookies don't spread).

Bake 425°F (convection) for 15-18 minutes until golden brown. Remove to wire rack immediately to cool.



Menu
Pineapple Teriyaki Chicken
Gluten-free Hawaiian Pizza (frozen cooked shells from Whole Foods)
BBQ Wings
Organic Turkey Hotdogs (no they're not nitrate-free)
Italian Tuna and Olives (in cupcake papers)
Snap Peas
Corn on the Cob
Olives
Garlic Mushrooms

Desserts
Almond Lemon Birthday Cake (gluten-free at Whole Foods)
Whipped Cream in Chocolate Shells (Whole Foods)
Cherries and Strawberries

(I said Paleo... not low-carb!)

Corona and Lime -- UR Mine

Corona and Lime
By Shwayze

Courtesy of Youtube.com

Will miss you... RIP

Adieu Amber Ale... So long, farewell, Hefeweizen! Bye-bye Bud Light...

The last wheat products to go...



My phytoestrogens will have to be sourced elsewhere like from barley-only beer -- GO HOP -- **hip-hop** HURRAY...

See below abstract -- Luv our microscopic friends and fauna that reside in our mile-long bowels! Treat them well...

In my former career as a research associate, I worked on barley and calmodulin (yes a target of Vitamin D -- who knew?). A great deal of my time was spent on northern blots (which takes a certain knack b/c RNA deteriorates easily) and southerns (DNA's durable Thank God). Yes, we were partially funded by the USDA (as well as beer companies.... j/k! maybe ??indirectly??). Had to test theories and research qualitative factors... after work beer with the post-docs and grad students was often a job requirement... no joke *hee*.

• Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin.
  Possemiers S, et al.
  J Agric Food Chem. 2005 Aug 10;53(16):6281-8.
  Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Gent University-UGent, Coupure 653, Gent, Belgium.
  Hop, an essential ingredient in most beers, contains a number of prenylflavonoids, among which 8-prenylnaringenin (8-PN) would be the most potent phytoestrogen currently known. Although a number of health effects are attributed to these compounds, only a few reports are available about the bioavailability of prenylflavonoids and the transformation potency of the intestinal microbial community. To test these transformations, four fecal samples were incubated with xanthohumol, isoxanthohumol (IX), and 8-PN. Upon incubation with IX, present in strong ales up to 4 mg/L, 36% was converted into 8-PN in one fecal sample and the estrogenic properties of the sample drastically increased. In an experiment with 12 fecal cultures, this conversion was observed in one-third of the samples, indicating the importance of interindividual variability in the intestinal microbial community. Eubacterium limosum was identified to be capable of this conversion (O-demethylation) of IX into 8-PN, and after strain selection, a conversion efficiency of 90% was achieved. Finally, strain supplementation to a nonconverting fecal sample led to rapid and high 8-PN production at only 1% (v/v) addition. Up to now, the concentration of 8-PN in beer was considered too low to affect human health. However, these results show that the activity of the intestinal microbial community could more than 10-fold increase the exposure concentration. Because prenylflavonoids are present in many beers with IX being the major constituent, the results raise the question whether moderate beer consumption might contribute to increased in vivo levels of 8-PN and even influence human health.
  PMID: 16076107



Stuff from my old lab below -- flora and fauna -- sometimes not much different. Many hormone actions and metabolic rules are conserved across nature.


• Nitric oxide acts as an antioxidant and delays programmed cell death in barley aleurone layers. Beligni MV, et al. Plant Physiol. 2002 Aug;129(4):1642-50.
• Hormonally regulated programmed cell death in barley aleurone cells. Bethke PC, et al. Plant Cell. 1999 Jun;11(6):1033-46.

Wheat: Would You Give Your Kids Crack?

Often the comments on Dr. Davis' HeartScanBlog are as insightful as his revolutionary ideas and core concepts. One vital core concept is wheat-cessation. From the entry 'I gained 30lbs from one cracker', Anne said... "Wheat protein contains a number of opioid peptides which can be released during digestion. Some of these are thought to affect the central and peripheral nervous systems. When I gave up gluten, I felt much worse for a few days. This is a very common reaction in those who stop eating gluten cold turkey." May 23, 2008

• Fukudome S, et al. Opioid peptides derived from wheat gluten: their isolation and characterization. FEBS Lett. 1992 Jan 13;296(1):107-11.
  Four opioid peptides were isolated from the enzymatic digest of wheat gluten. Their structures were Gly-Tyr-Tyr-Pro-Thr, Gly-Tyr-Tyr-Pro,Tyr-Gly-Gly-Trp-Leu and Tyr-Gly-Gly-Trp, which were named gluten exorphins A5, A4, B5 and B4, respectively. The gluten exorphin A5 sequence was found at 15 sites in the primary structure of the high molecular weight glutenin and was highly specific for delta-receptors. The structure-activity relationships of gluten exorphins A were unique in that the presence of Gly at their N-termini increased their activities. Gluten exorphin B5, which corresponds to [Trp4,Leu5]enkephalin, showed the most potent activity among these peptides. Its IC50 values were 0.05 microM and 0.017 microM, respectively, on the GPI and the MVD assays. PMID: 1309704

It's hard to give up wheat for most of us on the 'spectrum'... kinda like giving up narcotics (opioids). The withdrawal won't kill you like alcohol (seizures, DTs) or benzo withdrawal (seizures), but opioid, tobacco, and caffeine cessation share similar characterics with that of wheat cessation. For one, wheat digestion releases several feel-good chemicals called opioid peptides which provide a temporary sensation of satisfaction and satiation (basically a carb dose-dependent 'high'). Studies demonstrate that wheat can actually deliver equivalent doses of morphine (see below). The wheat chemicals are extremely short-lived and their quick drop in the blood concentrations leads to cravings for more wheat/carbs that can be difficult to control.... in fact they can be downright all-consuming and overwhelming for some (even those who work out like mad creatures *heh*).

Add in insulin surges and subsequent metabolic derangement and you've got a formula for an endless cycling of unsatisfying-feeding/craving. One of the most potent wheat opioid peptides B5 causes 'man-boobs' (as referenced by Kramer ala Seinfeld).

• Fanciulli G, et al. Gluten exorphin B5 stimulates prolactin secretion through opioid receptors located outside the blood-brain barrier. Life Sci. 2005 Feb 25;76(15):1713-9. PMID: 15698850

It's enough to make you hear voices 'eat me' 'EAT ME'. Here's the link with schizophrenia, one of many neuropsych conditions which are related to toxic effects of wheat and opioid peptides. Can food make you crazy? Apparently for many humans, yes.

• J Hum Nutr. 1980 Apr;34(2):107-12. Diet (gluten) and schizophrenia. Ross-Smith P, Jenner FA. Four aspects of clinical evidence for an association between gluten and schizophrenia are examined. The scientific evidence for the role of gluten is set out. Finally, reference is made to other dietary approaches. PMID: 6989901
• Peptides. 1984 Nov-Dec;5(6):1139-47. Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates. Huebner FR, Lieberman KW, Rubino RP, Wall JS.
  Because of a possible relationship between schizophrenia and celiac disease, a condition in some individuals who are sensitive to wheat gluten proteins in the diet, there has been interest in observations that peptides derived from wheat gluten proteins exhibit opioid-like activity in in vitro tests. To determine the origin of the peptides exhibiting opioid activity, wheat proteins were fractionated by size (gel filtration), by charge differences (ion exchange chromatography) and by differences in hydrophobicity (reversed-phase HPLC). These fractions were hydrolyzed by pepsin or pepsin and trypsin and the resulting peptides separated by gel filtration chromatography. The separated peptides were tested for opioid-like activity by competitive binding to opioid receptor sites in rat brain tissue in the presence of tritium-labeled dihydromorphine. The peptides showed considerable differences in activity; while some peptides exhibited no activity, 0.5 mg of the most active peptides were equivalent to 1 nM of morphine in the binding assay. The most active peptides were derived from the gliadin fraction of the gluten complex. PMID: 6099562

Would you feed your children crack-cocaine?

(yes, I admit we do when we don't plan ahead)

'Trigger' foods we avoid because they make us fall off the proverbial band wagon...
--Pepperidge farm GOLDFISH crackers

--Wheat thins
--Any breakfast cereal (hardly do we shop the inner aisles anymore)
--Trader Joe's frozen chocolate chip cookies


Why is wheat associated with so many autoimmune conditions?

The opioid peptides from wheat appear to trigger 'civil wars' and 'civil unrest' between the immune system and different organs in our bodies (including the Thyroid -- which HeartHawk is currently discussing)? Not only are wheat opioid peptides implicated in wreaking havoc on the immune system, but also in causing inordinate amounts of inflammation. And . . . inflammation leads to lymphoma (see end), cancer, and heart/vascular disease.

Manifestations of silent celiac disease

(predominantly extra-intestinal):
Dermatitis herpetiformis
Anemia
Autoimmune disorders (incl Hashimoto's, Grave's,

Sjögren’s, Type 1 DM,

Biliary cirrhosis, Psoriasis

Crohn's, Addison's)
Osteoporosis
Neurological disorders
Epilepsy with cerebral calcification
Neuropathy
Cerebellar ataxia
Chorea
Infertility/subfertility
Non-alcoholic fatty liver disease (NAFLD)
Unexplained chronic hypertransaminasemia

The above list originates from the below review article (full text here). If primary focal points of celiac-related inflammation leads to lymphoma (see last citation), then can silent asymptomatic celiac disease also cause heart disease? I believe so and that is why Dr. Davis' assertion for a wheat-cessation program as critical component in the plaque regression process. Are you getting tired of the 'low-fat' mantra? It's interesting how cholesterol and fat has yet to be blamed as the cause for cancer like they have for everything else.... HHhhhmmmm..... Does cholesterol really kill us? What is causing the rise in the conditions listed above? Including autism as well (see next to the last citation)?

Has the culprit always been wheat-c-a-r-b-o-h-y-d-r-a-t-e-s?

These scientists Ch'ng et al note a phenomenal explosion in the presentation of celiac conditions (silent and non-silent) in the last 30yrs. Is it coincidental this mirrors changes in the pathetic SAD (standard American diet) and low-fat 'paradigm shift' to an over-reliance on wheat and whole-grains? (Is whole-grains just whole-cr**p?) The celiac researchers report that most individuals with celiac disease have subtle or NO SYMPTOMS at all. In fact many test false negatively secondary to the changes in immunity (reduced IgA). Can treatment change the natural course or prevent autoimmune conditions (like Hashimoto's and Grave's disease)? Here at TYP, we strongly believe complete wheat withdrawal reverses many things. Including heart disease! These scientists summarize how research supports the improvement of many non-silent celiac disorders and the significant correction and resolution in auto-antibodies associated with Thyroid conditions.

• Ventura et al 39 found that diabetes- and thyroid-related antibodies tended to disappear following a gluten-free diet (11.1% at diagnosis, 5.6% at 6 months and none at 12 or 24 months follow-up for diabetes related antibodies and 14.4%, 11.1%, 6.6% and 2.2% for thyroid related antibodies, respectively)
• Identifying and treating CD in high-risk patients should confer benefit in reducing complications such as malabsorption, infertility, osteoporosis and lymphoma.95,96

Ch'ng CL, Jones MK, Kingham JG. Celiac disease and autoimmune thyroid disease. Clin Med Res. 2007 Oct;5(3):184-92.
Celiac disease (CD) or gluten sensitive enteropathy is relatively common in western populations with prevalence around 1%. With the recent availability of sensitive and specific serological testing, many patients who are either asymptomatic or have subtle symptoms can be shown to have CD. Patients with CD have modest increases in risks of malignancy and mortality compared to controls. The mortality among CD patients who comply poorly with a gluten-free diet is greater than in compliant patients.The pattern of presentation of CD has altered over the past three decades. Many cases are now detected in adulthood during investigation of problems as diverse as anemia, osteoporosis, autoimmune disorders, unexplained neurological syndromes, infertility and chronic hypertransaminasemia of uncertain cause. Among autoimmune disorders, increased prevalence of CD has been found in patients with autoimmune thyroid disease, type 1 diabetes mellitus, autoimmune liver diseases and inflammatory bowel disease. Prevalence of CD was noted to be 1% to 19% in patients with type 1 diabetes mellitus, 2% to 5% in autoimmune thyroid disorders and 3% to 7% in primary biliary cirrhosis in prospective studies. Conversely, there is also an increased prevalence of immune based disorders among patients with CD.The pathogenesis of co-existent autoimmune thyroid disease and CD is not known, but these conditions share similar HLA haplotypes and are associated with the gene encoding cytotoxic T-lymphocyte-associated antigen-4. Screening high risk patients for CD, such as those with autoimmune diseases, is a reasonable strategy given the increased prevalence.Treatment of CD with a gluten-free diet should reduce the recognized complications of this disease and provide benefits in both general health and perhaps life expectancy. It also improves glycemic control in patients with type 1 diabetes mellitus and enhances the absorption of medications for associated hypothyroidism and osteoporosis. It probably does not change the natural history of associated autoimmune disorders. PMID: 18056028

Kawashti MI, Amin OR, Rowehy NG. Possible immunological disorders in autism: concomitant autoimmunity and immune tolerance. Egypt J Immunol. 2006;13(1):99-104.
Autism is a pervasive developmental disorder that affect children early in their life. Immunological disorders is one of several contributing factors that have been suggested to cause autism. Thirty autistic children aged 3-6 years and thirty non-autistic psychologically-free siblings were studied. Circulating IgA and IgG autoantibodies to casein and gluten dietary proteins were detected by enzyme-immunoassays (EIA). Circulating IgG antibodies to measles, mumps and rubella vaccine (M.M.R) and cytomeglovirus were investigated by EIA. Results revealed high seropositivity for autoantibodies to casein and gluten: 83.3% and 50% respectively in autistic children as compared to 10% and 6.7% positivity in the control group. Surprisingly, circulating anti-measles, anti-mumps and anti-rubella IgG were positive in only 50%, 73.3% and 53.3% respectively as compared to 100% positivity in the control group. Anti-CMV IgG was positive in 43.3% of the autistic children as compared to 7% in the control group. It is concluded that, autoimmune response to dietary proteins and deficient immune response to measles, mumps and rubella vaccine antigens might be associated with autism, as a leading cause or a resulting event. Further research is needed to confirm these findings. PMID: 17974154

Hoggan R. Considering wheat, rye, and barley proteins as aids to carcinogens. Med Hypotheses. 1997 Sep;49(3):285-8. The increased incidence of lymphoma in celiac sprue (CS) is well documented, and the risk of developing this malignancy is 40-100-fold greater than in the general population. The author believes that gluten may also be at the root of lymphomas in asymptomatic and latent celiac sprue, as well. Among the 20-30% of the population which has the HLA factors most common in celiac, increased intestinal permeability leads to absorption of macromolecular peptides with opioid activity, which derive from pepsin digests of wheat. The presence, in the bloodstream, of these peptides may increase the risk of lymphomas for the entire hereditary group, which includes CS. Several processes contribute to the effect that is herein hypothesized, including opioid attachment at the hypothalamic-pituitary-adrenal axis (HPA), and subsequent downregulation of production of natural killer cells. This may offer an explanation for our longstanding awareness that there is an 'impaired lymphocyte reactivity against tumor cells in patients with coeliac disease' which may also apply to first-degree relatives with the same HLA markers. PMID: 9293475